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公开(公告)号：WO2017062198A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/053680
申请日：2016-09-26
发明人： ANDERSON-CUNANAN, Crystal M. , FAZACKERLEY, Katherine C. , EPPIHIMER, Michael , KENWOOD, Shannon Smith , SUSHKOVA, Natalia P. , LAVERY, Karen Suzanne
CPC分类号： A61F2/2415 , A61F2/2412 , A61F2/2418 , A61L27/3687 , A61L27/3804 , A61L27/3826 , A61L27/3873 , A61L27/3886 , A61L27/3895 , A61L27/507 , A61L2430/20 , C12M21/08 , C12N5/0656 , C12N5/0661 , C12N2502/1347 , C12N2527/00 , C12N2537/10
摘要： A prosthetic heart valve provided herein can include a cultured cell tissue leaflet. In some cases, a prosthetic heart valve can include a plurality of leaflets secured together and retained within the expandable tubular member. The cultured cell tissue can be obtained by culturing fibroblast cells, smooth muscle cells, or a combination thereof to form a sheet of cultured cells and chemically cross-linking the fibroblast cells while under tension. In some cases, the cultured cell tissue can be radially tensioned. In some cases, the cultured cell tissue can be bi-axially tensioned.
摘要翻译： 本文提供的假体心脏瓣膜可以包括培养的细胞组织小叶。 在一些情况下，假体心脏瓣膜可以包括固定在一起并保持在可扩张管状构件内的多个小叶。 培养的细胞组织可以通过培养成纤维细胞，平滑肌细胞或其组合来形成培养细胞片并在张力下化学交联成纤维细胞。 在一些情况下，培养的细胞组织可以径向张紧。 在一些情况下，培养的细胞组织可以被双轴向张紧。
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公开(公告)号：WO2019005827A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/039548
申请日：2018-06-26
发明人： CLARK, Joshua , STORBECK, Gene T. , KENWOOD, Shannon Smith , BENNING, Christopher A. , CURRAN, Sean , HEIGHTON, Sarah Jean
CPC分类号： G01N1/31 , A61B10/0283 , B01L3/5021 , B01L9/52 , B01L2300/0618 , B01L2300/0681 , B01L2300/12 , B01L2300/16 , B01L2400/0409 , C12M3/062 , C12M33/14 , C12M47/02 , G01N1/36 , G01N1/4077 , G01N33/5088 , G01N2001/2873 , G01N2001/4088
摘要： A cell filtration assembly adapted to capture cells from a biological sample during centrifugation includes a filter support member including a sample well and a filter membrane that spans the sample well. In some cases, the filter support member and/or the filter membrane may be adapted to be sectioned. In some cases, a protective element may be disposed over at least a portion of the filter support member in order to protect the filter support member from tissue processing reagents during processing of the cells captured from the biological sample.
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公开(公告)号：WO2019006139A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040046
申请日：2018-06-28
CPC分类号： B01L3/5021 , B01D21/262 , B01D61/18 , B01D63/087 , B01D2311/2676 , B01D2313/025 , B01D2315/02 , B01L2200/025 , B01L2300/0681 , B01L2300/0809 , B01L2300/0832 , B01L2400/0409 , B01L2400/08 , G01N2001/4088
摘要： A cell filtration assembly adapted to capture cells from a biological sample during centrifugation includes a centrifugation tube, a cell collection device adapted to be secured within a tapered end of the centrifugation tube and a funnel structure adapted to direct fluid into the cell collection device. The cell collection device includes a rectilinear structure that is adapted to permit fluid to flow through the rectilinear structure and a cell capture surface that is secured relative to the rectilinear structure. The cell collection device may be sectioned in either a horizontal or vertical orientation.
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公开(公告)号：WO2019006303A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040293
申请日：2018-06-29
CPC分类号： A61B10/0283 , A61B5/15003 , A61B5/150236 , A61B5/150244 , A61B5/153 , A61B10/0266 , A61B10/04 , A61B2010/0208 , A61B2010/045 , A61M1/0056
摘要： A tissue filtration device (100) may include an elongate hollow needle assembly (102) having open distal (114) and proximal (116) ends. In some cases, the tissue filtration device may include a collection device (104) containing a filter material (128) and coupled to the elongate hollow needle assembly and in fluid communication with the elongate hollow needle (108). Also included may be a suction assembly (106) coupled to the collection device and configured to draw fluid from the elongate hollow needle assembly into the collection device.
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公开(公告)号：WO2019005809A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/039522
申请日：2018-06-26
CPC分类号： B04B5/0442 , B01D21/262 , B01D61/147 , B01D61/18 , B01D2221/10 , B01D2311/2676 , B01L3/5021 , B01L2200/025 , B01L2300/0618 , B01L2300/0681 , B01L2400/0409 , B04B2005/0478 , C12M47/02 , G01N1/4077 , G01N2001/4088
摘要： Filtration devices and methods for collecting, filtering, and/or processing biological samples are disclosed. An example filtration device may include a funnel member having a first end region and a second end region. A flange may be coupled to the first end region. A filter support portion may be coupled to the second end region. The filter support portion may include a base, a filter membrane coupled to the base, and a securing member for securing the filter membrane to the base.
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