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1.发明申请ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR 审中-公开ENEDIYNE化合物，其结合物及其用途及其用途
公开(公告)号：WO2013122823A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025247
申请日：2013-02-08
IPC分类号： C07D491/08 , A61K31/4741 , A61K31/475 , A61P35/00
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R 0 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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公开(公告)号：WO2019209811A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/028697
申请日：2019-04-23
发明人： PURANDARE, Ashok V. , WAN, Honghe , HE, Liqi , GANGWAR, Sanjeev , POSY, Shoshana L. , POUDEL, Yam B. , SIVAPRAKASAM, Prasanna , CHOWDARI, Naidu S.
IPC分类号： C07D487/22 , A61K31/522
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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3.发明申请
公开(公告)号：WO2018075842A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/057508
申请日：2017-10-20
发明人： MCDONALD, Ivar M. , SIVAPRAKASAM, Prasanna , IWUAGWU, Christiana I. , PEESE, Kevin M. , CHENG, Heng , CHOWDARI, Naidu S. , GANGWAR, Sanjeev
IPC分类号： C07D471/04 , A61K31/5513 , A61P35/00
摘要： A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
摘要翻译： 能够抑制细胞增殖的化合物，具有根据式（I）的结构，其中式（I）中的变量如说明书中所定义。 这些化合物可用作抗癌剂，特别是在抗体 - 药物偶联物中。
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公开(公告)号：WO2021207511A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026408
申请日：2021-04-08
IPC分类号： C07D493/10 , A61P35/00 , A61K31/35 , C07D405/14 , C07D407/06 , C07D417/14
摘要： Compounds according to formula (I), where R is as defined herein, have anti-cancer properties.
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公开(公告)号：WO2021154664A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014978
申请日：2021-01-26
发明人： TARBY, Christine M. , BROEKEMA, Matthias , GAVAI, Ashvinikumar V. , GANGWAR, Sanjeev , CHOWDARI, Naidu S. , JOHNSON, Walter L. , ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：WO2021154666A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014980
申请日：2021-01-26
发明人： COX, Matthew , CHOWDARI, Naidu S. , GAVAI, Ashvinikumar V. , GANGWAR, Sanjeev , TARBY, Christine M. , POUDEL, Yam , ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah
IPC分类号： C07D487/04
摘要： Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). (I) (II) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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7.发明申请
公开(公告)号：WO2020028608A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044575
申请日：2019-08-01
发明人： POUDEL, Yam B. , GANGWAR, Sanjeev , HE, Liqi , SIVAPRAKASAM, Prasanna , BROEKEMA, Matthias , CHOWDARI, Naidu S. , COX, Matthew , TARBY, Christine M. , ZHANG, Qian
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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8.发明申请BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 审中-公开苯并二唑二聚体，其结合物及其制备和使用方法
公开(公告)号：WO2016115191A1
公开(公告)日：2016-07-21
申请号：PCT/US2016/013136
申请日：2016-01-13
发明人： ZHANG, Yong , MCDONALD, Ivar M. , CHOWDARI, Naidu S. , HUYNH, Tram N. , BORZILLERI, Robert M. , GANGWAR, Sanjeev
IPC分类号： C07D519/00 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
摘要翻译： 具有由式（I），（Ia）和（Ib）中的变量表示的结构的苯并二氮杂二聚体如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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