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公开(公告)号：WO2019126253A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066366
申请日：2018-12-19
发明人： DYCKMAN, Alaric J. , MUSSARI, Christopher P. , HAQUE, Tasir Shamsul , WHITELEY, Brian K. , POSY, Shoshana L. , KUMAR, Sreekantha Ratna , KUMAR, Sreekantha Ratna , HEGDE, Subramanya , RAMACHANDRA REDDY, Anupama Kandhi , ANUMULA, Rushith Kumar
IPC分类号： C07D209/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D453/02 , C07D471/04 , C07D487/04 , C07D513/04 , A61P37/00 , A61K31/4353
CPC分类号： A61P37/00 , C07D209/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D453/02 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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2.发明申请
公开(公告)号：WO2018005586A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039633
申请日：2017-06-28
发明人： DYCKMAN, Alaric J. , DODD, Dharmpal S. , HAQUE, Tasir Shamsul , LOMBARDO, Louis J. , MACOR, John E. , MUSSARI, Christopher P. , PASUNOORI, Laxman , RATNA KUMAR, Sreekantha , SHERWOOD, Trevor C. , POSY, Shoshana L. , SISTLA, Ramesh Kumar , HEGDE, Subramaya , RAMACHANDRA, Anupama
IPC分类号： C07D471/04 , A61K31/437
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物或其盐，其中R 1，R 2，R 3，R 3， ，R 4，R 5，m，n和p在本文中定义。 还公开了使用这些化合物作为通过Toll样受体7或8或9的信号传导抑制剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗炎症和自身免疫性疾病。
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公开(公告)号：WO2021067657A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053886
申请日：2020-10-02
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04 , A61P29/00 , A61K31/437
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：WO2019126253A8
公开(公告)日：2019-06-27
申请号：PCT/US2018/066366
申请日：2018-12-19
发明人： DYCKMAN, Alaric J. , MUSSARI, Christopher P. , HAQUE, Tasir Shamsul , WHITELEY, Brian K. , POSY, Shoshana L. , KUMAR, Sreekantha Ratna , PASUNOORI, Laxman , HEGDE, Subramanya , RAMACHANDRA REDDY, Anupama Kandhi , ANUMULA, Rushith Kumar
IPC分类号： C07D209/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D453/02 , C07D471/04 , C07D487/04 , C07D513/04 , A61P37/00 , A61K31/4353
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：WO2019126081A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066106
申请日：2018-12-18
发明人： DYCKMAN, Alaric J. , DODD, Dharmpal S. , MUSSARI, Christopher P. , SHERWOOD, Trevor C. , HAQUE, Tasir Shamsul , POSY, Shoshana L. , KUMAR, Sreekantha Ratna , PASUNOORI, Laxman , HEGDE, Subramanya , ANUMULA, Rushith Kumar
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/12 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D209/12 , A61K31/407 , A61P37/00
CPC分类号： C07D487/04 , C07D209/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D471/10 , C07D487/08
摘要： N-oxides, or salts thereof, wherein G, L 2 , R 1 , R 5 , R 9 , R 10 , and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：WO2019126242A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066344
申请日：2018-12-19
发明人： DYCKMAN, Alaric J. , DODD, Dharmpal S. , MUSSARI, Christopher P. , TORTOLANI, David R. , HAQUE, Tasir Shamsul , POSY, Shoshana L.
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D471/04 , C07D491/20 , C07D209/12 , A61P37/00 , A61K31/4353
CPC分类号： C07D401/14 , A61P37/00 , C07D209/12 , C07D401/12 , C07D403/04 , C07D403/14 , C07D405/12 , C07D471/04 , C07D491/20
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：WO2018049089A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050577
申请日：2017-09-08
发明人： DYCKMAN, Alaric J. , DODD, Dharmpal S. , HAQUE, Tasir Shamsul , LOMBARDO, Louis J. , MACOR, John E. , MUSSARI, Christopher P. , PASUNOORI, Laxman , POSS, Michael A. , RATNA KUMAR, Sreekantha , POSY, Shoshana L. , TORTOLANI, David R. , WHITELEY, Brian , SISTLA, Ramesh Kumar , HEGDE, Subramaya , RAMACHANDRA, Anupama
IPC分类号： C07D401/14 , A61K31/4427 , A61K31/444
摘要： Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的N-氧化物或其盐，其中R 1，R 2，R 3 R 4，R 5，m，n和p在本文中定义。 还公开了使用这些化合物作为通过Toll样受体7或8或9的信号传导抑制剂的方法，以及包含这些化合物的药物组合物。 这些化合物可用于治疗炎症和自身免疫性疾病。
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公开(公告)号：WO2020086503A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057311
申请日：2019-10-22
IPC分类号： C07D471/04 , C07D491/107 , C07D495/10 , A61P37/00 , A61K31/437 , A61K31/4545
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X is CR 1 or N; and G, A, R 1 , and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：WO2019209811A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/028697
申请日：2019-04-23
发明人： PURANDARE, Ashok V. , WAN, Honghe , HE, Liqi , GANGWAR, Sanjeev , POSY, Shoshana L. , POUDEL, Yam B. , SIVAPRAKASAM, Prasanna , CHOWDARI, Naidu S.
IPC分类号： C07D487/22 , A61K31/522
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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公开(公告)号：WO2019126113A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066149
申请日：2018-12-18
发明人： DYCKMAN, Alaric J. , DODD, Dharmpal S. , MUSSARI, Christopher P. , GILMORE, John L. , HAQUE, Tasir Shamsul , SHERWOOD, Trevor C. , WHITELEY, Brian K. , POSY, Shoshana L. , KUMAR, Sreekantha Ratna , PASUNOORI, Laxman , DURAISAMY, Srinivasan Kunchithapatham , HEGDE, Subramanya , ANUMULA, Rushith Kumar , SRINIVAS, Pitani Veera Venkata
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D519/00 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D453/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D519/00
摘要： Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R 1 , R 5 , and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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