公开(公告)号：WO2017014167A1

公开(公告)日：2017-01-26

申请号：PCT/JP2016/070924

申请日：2016-07-11

Applicant: CANON KABUSHIKI KAISHA

Inventor： SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

IPC: A61B8/13

CPC classification number: A61B5/0095

Abstract: An object information acquiring apparatus includes: a light source radiating first light having a first wavelength λ1 and second light having a second wavelength λ2; a detection unit detecting an acoustic wave generated from an object irradiated with the light, and converting the acoustic wave into a detection signal; and a signal processing unit acquiring characteristic information of the inside of the object based on the detection signal. The signal processing unit acquires the characteristic information by performing subtraction processing between a signal generated as a result of the first light being absorbed by hemoglobin and a signal generated as a result of the second light being absorbed by hemoglobin.

Abstract translation: 对象信息获取装置包括：发射具有第一波长λ1的第一光和第二波长λ2的第二光的光源; 检测单元，检测从被照射的物体产生的声波，并将声波转换成检测信号; 以及信号处理单元，其基于检测信号获取对象内部的特征信息。 信号处理单元通过执行作为由血红蛋白吸收的第一光的结果产生的信号和作为由血红蛋白吸收的第二光的结果而产生的信号之间的减法处理来获取特征信息。

公开(公告)号：WO2012026608A1

公开(公告)日：2012-03-01

申请号：PCT/JP2011/069370

申请日：2011-08-23

Applicant: CANON KABUSHIKI KAISHA ,  ITO, Shinzaburo ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  FUKUI, Tatsuki ,  KATO, Kouichi ,  YAMAUCHI, Fumio ,  TOMIDA, Yoshinori ,  YUASA, Satoshi ,  YANO, Tetsuya ,  OGAWA, Satoshi ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

Inventor： ITO, Shinzaburo ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  FUKUI, Tatsuki ,  KATO, Kouichi ,  YAMAUCHI, Fumio ,  TOMIDA, Yoshinori ,  YUASA, Satoshi ,  YANO, Tetsuya ,  OGAWA, Satoshi ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

IPC: A61K49/00 ,  A61K49/22 ,  B82Y5/00 ,  A61K9/51

CPC classification number: A61K49/0093 ,  A61K9/5153 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/225 ,  B82Y15/00 ,  B82Y30/00

Abstract: There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

Abstract translation: 提供了一种负载ICG的聚合物纳米颗粒，其动态稳定，防止所含ICG的泄漏和所得的变色，并具有高的摩尔吸光系数。 该颗粒含有具有磺酸盐基团和疏水性聚合物的亲水性染料，并且该颗粒还含有具有带正电荷区域的脂质，烟酸衍生物和硫胺衍生物中的至少一种。

公开(公告)号：WO2014013730A1

公开(公告)日：2014-01-23

申请号：PCT/JP2013/004359

申请日：2013-07-17

Applicant: CANON KABUSHIKI KAISHA

Inventor： YAMAUCHI, Fumio ,  OGAWA, Satoshi ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi ,  MINAMI, Masato ,  FUKUI, Tatsuki

IPC: A61K49/00 ,  C07D209/12 ,  C07D209/14

CPC classification number: A61K49/221 ,  C07D209/12 ,  C07D209/14 ,  C07D209/60 ,  C07D403/14 ,  C07K7/06 ,  C07K16/40 ,  C07K2317/622

Abstract: The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.

Abstract translation: 本发明提供即使在进行给药后经过一定程度的时间后也显示出高度积累于肿瘤的化合物，并且有利于由肿瘤产生的光声信号强度的增加。 通过聚乙二醇与特定花青类化合物的结合制得的化合物。

公开(公告)号：WO2003107377A1

公开(公告)日：2003-12-24

申请号：PCT/JP2003/007544

申请日：2003-06-13

Applicant: CANON KABUSHIKI KAISHA ,  ICHIKAWA, Takeshi ,  FUJIWARA, Ryoji ,  SASAGURI, Daisuke

Inventor： ICHIKAWA, Takeshi ,  FUJIWARA, Ryoji ,  SASAGURI, Daisuke

IPC: H01J1/304

CPC classification number: H01J9/025 ,  H01J1/3048

Abstract: There is provided an electron-emitting device of a field emission type, with which the spot size of an electron beam is small, an electron emission area is large, highly efficient electron emission is possible with a low voltage, and a manufacturing process is easy. The electron-emitting device includes a layer 2 which is electrically connected to a cathode electrode 5, and a plurality of particles 3 which contains a material having resistivity lower than that of a material constituting the layer 2, and is wherein a density of particles 3 in the layer 2 is 1 x 10 14 /cm 3 or more and 5 x 10 18 /cm 3 or less.

Abstract translation: 提供了一种场致发射型电子发射装置，其电子束的光点尺寸小，电子发射面积大，电子发射能够以低电压发射，制造工艺容易 。 电子发射器件包括电连接到阴极电极5的层2和包含比构成层2的材料的电阻率低的材料的多个颗粒3，其中颗粒3的密度 在层2中为1×10 14 / cm 3以上且5×10 18 / cm 3以下。

公开(公告)号：WO2016092799A1

公开(公告)日：2016-06-16

申请号：PCT/JP2015/006045

申请日：2015-12-04

Applicant: CANON KABUSHIKI KAISHA

Inventor： MIZUSAWA, Keigo ,  FUKUI, Tatsuki ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

IPC: C07D209/60 ,  A61K31/403 ,  A61K49/00

CPC classification number: C09K11/06 ,  A61K49/0032 ,  A61K49/0054 ,  C07D209/60 ,  C09K2211/1466 ,  G01N2800/7028

Abstract: To provide a compound of formulaes (I), (II) and (III) having high T/B and a contrast agent for optical imaging. The compound has a molecular weight of a specific range, the compound in which two polyethylene glycols are bonded to a specific cyanine pigment through a linker. The present invention provides a compound which has a high T/B and which can be used as a contrast agent capable of imaging a tumor portion with high contrast.

Abstract translation: 提供具有高T / B的式（I），（II）和（III）的化合物和用于光学成像的造影剂。 该化合物具有特定范围的分子量，其中两个聚乙二醇通过接头与特定花青颜料结合的化合物。 本发明提供了具有高T / B的化合物，其可以用作能够以高对比度成像肿瘤部分的造影剂。

公开(公告)号：WO2014013729A1

公开(公告)日：2014-01-23

申请号：PCT/JP2013/004358

申请日：2013-07-17

Applicant: CANON KABUSHIKI KAISHA

Inventor： TAKAHASHI, Atsushi ,  OGAWA, Satoshi ,  YAMAUCHI, Fumio ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  MINAMI, Masato

IPC: A61K49/22

CPC classification number: A61K49/221 ,  A61K49/225

Abstract: There is provided a contrast agent for photoacoustic imaging, the contrast agent exhibiting high tumor accumulation and high photoacoustic signal intensity even when time has passed since administration. A contrast agent for photoacoustic imaging comprises a complex including albumin covalently bound to an organic dye that absorbs light in the near-infrared wavelength region.

Abstract translation: 提供了一种用于光声成像的造影剂，即使在给药后经过了时间，造影剂显示高肿瘤积聚和高光声信号强度。 用于光声成像的造影剂包括与吸收近红外波长区域中的光的有机染料共价结合的白蛋白的复合物。