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    METHOD AND SYSTEM FOR FABRICATING DNA SEQUENCING ARRAYS
    2.
    发明申请
    METHOD AND SYSTEM FOR FABRICATING DNA SEQUENCING ARRAYS 审中-公开

    公开(公告)号：WO2019183272A1

    公开(公告)日：2019-09-26

    申请号：PCT/US2019/023245

    申请日：2019-03-20

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： DENTINGER, Paul ,  COSTA, Justin ,  MCGALL, Glenn ,  CRNOGORAC, Filip ,  ZHOU, Wei

    IPC: C40B50/18 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q1/6874

    Abstract: The present disclosure relates to processes for inverting oligonucleotide probes in an in situ synthesized array. These processes can be used to reverse the orientation of probes with respect to the substrate from 3'-bound to a substrate to 5'-bound to another substrate. These processes can also be used to reduce or eliminate the presence of truncated probe sequences from an in situ synthesized array. These processes can preserve the original patterns of the synthesized oligonucleotide after the inversion. These process can be achieved via the formation of a hydrogel layer in-between a donor substrate and an acceptor substrate through a polymerization reaction forming the hydrogel layer.

    SYSTEMS AND METHODS FOR CHEMICAL SYNTHESIS ON WAFERS
    5.
    发明申请
    SYSTEMS AND METHODS FOR CHEMICAL SYNTHESIS ON WAFERS 审中-公开

    公开(公告)号：WO2021159078A1

    公开(公告)日：2021-08-12

    申请号：PCT/US2021/017091

    申请日：2021-02-08

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： LI, Bolan ,  MCGALL, Glenn ,  CRNOGORAC, Filip ,  HACK, Christopher Alan ,  ZHOU, Wei

    IPC: B01J8/02 ,  H01L21/67

    Abstract: The present disclosure provides methods, device, and system for wafer processing. The wafer processing apparatus uses a nozzle in a lid to disperse a solution to the surface of a wafer. Further, the wafer is positioned on top of a vacuum chuck and does not spin while the solution is dispensed over the surface of the wafer via surface tension, thereby permitting the first solution to react with a reagent on the surface. Further, when dispensing the first solution, a separation gap between the lid and the wafer is at a predetermined distance, for example, from about 20 μm to about 2 mm.

    INCREASING EFFICIENCY OF PHOTOCHEMICAL REACTIONS ON SUBSTRATES
    6.
    发明申请
    INCREASING EFFICIENCY OF PHOTOCHEMICAL REACTIONS ON SUBSTRATES 审中-公开

    公开(公告)号：WO2019232067A1

    公开(公告)日：2019-12-05

    申请号：PCT/US2019/034418

    申请日：2019-05-29

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： MCGALL, Glenn ,  CRANDALL, Darren ,  LI, Bolan ,  DENTINGER, Paul

    IPC: C12Q1/00 ,  C12Q1/28 ,  C12Q1/68

    Abstract: Disclosed herein is a substrate which includes a functional group protected with a photolabile group covalently attached to the substrate and a film of solvent thereof covering the substrate, where the thickness of the film is less than about 100 µm. Also disclosed herein are methods of preparing such substrates. Further disclosed are methods of synthesizing polymers, methods of synthesizing arrays of polymers and methods of removing photolabile protecting groups. These methods all employ covering the substrate with a thin film of solvent where the thickness of the film is less than 100 µm.

    METHODS FOR FABRICATING HIGH RESOLUTION DNA ARRAY AND ITS APPLICATION IN SEQUENCING
    7.
    发明申请
    METHODS FOR FABRICATING HIGH RESOLUTION DNA ARRAY AND ITS APPLICATION IN SEQUENCING 审中-公开

    公开(公告)号：WO2019136322A1

    公开(公告)日：2019-07-11

    申请号：PCT/US2019/012444

    申请日：2019-01-05

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： CRNOGORAC, Filip ,  MCGALL, Glenn ,  DENTINGER, Paul ,  POLLOM, T. Scott ,  ZHOU, Wei

    IPC: C40B50/14 ,  C07H21/04 ,  C40B40/06 ,  C40B60/14

    Abstract: The present disclosure provides methods and processes for forming a pattern of oligonucleotides on a microarray. A method for forming a pattern of oligonucleotides on a microarray may include forming a photoresist layer by applying a photoresist composition onto an underlying layer of a substrate, exposing a dose of light through a patterned mask onto the substrate, and removing protective groups on a section of the plurality of functional groups within at least one exposed region of the substrate, wherein the photoresist composition comprises a photoacid generator, an acid scavenger and a photosensitizer, wherein the underlying layer comprises a plurality of functional groups protected by protective groups; thereby forming a pattern on the substrate, wherein the pattern comprises the at least one exposed region, and wherein the at least one exposed region is no more than 1 micrometer in at least one dimension.

    SYSTEM FOR AUTOMATED SYNTHESIS OF BIOCHIPS
    8.
    发明申请
    SYSTEM FOR AUTOMATED SYNTHESIS OF BIOCHIPS 审中-公开

    公开(公告)号：WO2021159107A1

    公开(公告)日：2021-08-12

    申请号：PCT/US2021/017135

    申请日：2021-02-08

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： LI, Bolan ,  SIKORA, Uzair Yousuf ,  MCGALL, Glenn ,  HACK, Christopher Alan ,  ZHOU, Wei

    IPC: G03F7/16 ,  B01J19/00 ,  C12N15/10

    Abstract: The present disclosure provides methods, device, and system for biochips manufacturing including a wafer processing apparatus such as a spin cell platform, a synthesizer, a wafer handling robot, an ultraviolet aligner, and a wafer centering device. The wafer processing apparatus uses a nozzle in a lid to disperse a solution to the surface of a wafer. Further, the wafer is positioned on top of a vacuum chuck and does not spin while the solution is dispensed over the surface of the wafer via surface tension, thereby permitting the first solution to react with a reagent on the surface. Further, when dispensing the first solution, a separation gap between the lid and the wafer is at a predetermined distance, for example, from about 20 micrometer to about 200 micrometer.

    OLIGONUCLEOTIDE PROBE ARRAY WITH ELECTRONIC DETECTION SYSTEM
    9.
    发明申请
    OLIGONUCLEOTIDE PROBE ARRAY WITH ELECTRONIC DETECTION SYSTEM 审中-公开

    公开(公告)号：WO2018222800A2

    公开(公告)日：2018-12-06

    申请号：PCT/US2018/035282

    申请日：2018-05-31

    Applicant: CENTRILLION TECHNOLOGIES, INC.

    Inventor： ZHOU, Wei ,  MCGALL, Glenn ,  MEI, Rui ,  CRNOGORAC, Filip

    IPC: C12Q1/68 ,  G06F19/20

    Abstract: The present disclosure provides methods, device, and system for a hybridization assay to detect nucleic acid targets. The assay may use a probe array format with addressable microwells. Each microwell may retain a plurality of copies of one probe which may be complementary to a portion of a specific nucleic acid target. The plurality of copies of probes may be produced from a pooled library of probe sequences by amplification techniques, including, rolling circle amplification and emulsion-PCR. Detection of hybridization may rely on methods using ion-sensitive field effect transistor (ISFET) and optical detectors to detect signals indicating the presence of the nucleic acid targets.

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