公开(公告)号：WO2006135759A1

公开(公告)日：2006-12-21

申请号：PCT/US2006/022504

申请日：2006-06-09

Applicant: COOK INCORPORATED ,  BOATMAN, Scott ,  BURTON, David, G.

Inventor： BOATMAN, Scott ,  BURTON, David, G.

IPC: A61M25/10 ,  A61M25/00

CPC classification number: A61M25/0054 ,  A61M25/10

Abstract: A balloon catheter is provided to minimize curving of the balloon when the balloon is expanded with an inflation media. The balloon catheter has an elastic inner shaft that stretches longitudinally as inflation pressure in the balloon is increased. The balloon catheter may also have an inner shaft with a portion that is corrugated to allow longitudinal stretching of the inner shaft.

Abstract translation: 气球导管被设置成当气囊用充气介质膨胀时使球囊的弯曲最小化。 气球导管具有弹性内轴，其随着球囊中的充气压力增加而纵向延伸。 球囊导管也可以具有内轴，其具有波纹状的部分，以允许内轴的纵向拉伸。

公开(公告)号：WO2004006976A1

公开(公告)日：2004-01-22

申请号：PCT/US2003/022040

申请日：2003-07-14

Applicant: COOK INCORPORATED ,  MED INSTITUTE INC. ,  WILLIAM COOK EUROPE ApS

Inventor： BATES, Brian, L. ,  BOATMAN, Scott, E. ,  BURTON, David, G. ,  HOFFA, Michael, C. ,  RAGHEB, Anthony, O. ,  SCHAEFFER, Darin, G. ,  STURGEON, Jason, S.

IPC: A61L31/16

CPC classification number: A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

Abstract translation: 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

公开(公告)号：WO2009114425A1

公开(公告)日：2009-09-17

申请号：PCT/US2009/036361

申请日：2009-03-06

Applicant: COOK INCORPORATED ,  SABIN CORPORATION ,  BURTON, David, G. ,  DREWES, David, A. ,  SCHAEFFER, Darin, G.

Inventor： BURTON, David, G. ,  DREWES, David, A. ,  SCHAEFFER, Darin, G.

IPC: A61M25/10 ,  A61M25/00

CPC classification number: A61B17/320725 ,  A61B2017/22061 ,  A61M25/10 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/1038 ,  A61M25/104 ,  A61M29/02 ,  A61M2025/1086 ,  B29C49/04 ,  B29C49/20 ,  B29C2049/2017 ,  B29K2067/003 ,  B29K2077/00 ,  B29L2031/7543

Abstract: A balloon catheter is provided that may be used to dilate hardened regions of a stenosis. The balloon catheter is provided with one or more dilation elements (130, 320) that extend along a surface of a balloon (140, 311). Each dilation element (130, 320) is connected to an outer surface (140, 311) of the balloon by a connector (120, 330). The connector (120, 330) is sufficiently sized and designed to undergo stress-induced plastic deformation incurred during blow molding so that a significant portion of each of the dilation elements (130, 320) does not become absorbed into the wall of the final blow molded balloon (150), thereby maintaining the structural integrity of each of the dilation elements (130, 320).

Abstract translation: 提供了可用于扩张狭窄的硬化区域的气囊导管。 球囊导管设置有沿着气囊（140,311）的表面延伸的一个或多个扩张元件（130,320）。 每个扩张元件（130,320）通过连接器（120,330）连接到球囊的外表面（140,311）。 连接器（120,330）具有足够的尺寸和设计，以在吹塑过程中发生应力引起的塑性变形，使得每个膨胀元件（130,320）的大部分不被吸收到最终吹塑的壁中 从而保持每个膨胀元件（130,320）的结构完整性。

公开(公告)号：WO2006073933A2

公开(公告)日：2006-07-13

申请号：PCT/US2005/047054

申请日：2005-12-28

Applicant: COOK INCORPORATED ,  MELSHEIMER, Jeffry, S. ,  BURTON, David, G.

Inventor： MELSHEIMER, Jeffry, S. ,  BURTON, David, G.

IPC: A61M25/00 ,  A61B17/22

CPC classification number: A61B17/320725 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61M25/1027 ,  A61M25/1038 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1086 ,  A61M2025/109

Abstract: A balloon catheter assembly comprises an elongate catheter shaft having a proximal portion and a distal portion, and an inflatable balloon secured to the shaft distal portion. A plurality of cutters are arranged along an outer surface of the balloon. The cutters are shielded by folds of the balloon when the balloon is uninflated, and are arranged and configured to facilitate breakdown of a vascular restriction when said balloon is inflated. Preferably, the cutters are arranged in at least three generally parallel longitudinal rows along the balloon outer surface, and there are at least three longitudinally-aligned cutters in each row. Preferably, the cutters are formed of the same or a similar base composition as the balloon, and are bonded to the balloon outer surface.

Abstract translation: 气囊导管组件包括具有近端部分和远端部分的细长导管轴和固定到轴远端部分的可充气球囊。 沿着气囊的外表面布置多个切割器。 当球囊未膨胀时，切割器被气囊的折叠物屏蔽，并且被布置和构造成便于当所述气囊膨胀时促进血管限制的破坏。 优选地，切割器沿着球囊外表面布置在至少三个大致平行的纵向排中，并且每排中至少有三个纵向对齐的切割器。 优选地，切割器由与球囊相同或相似的基础组合物形成，并且结合到球囊外表面。

公开(公告)号：WO2005004967A2

公开(公告)日：2005-01-20

申请号：PCT/US2004/020934

申请日：2004-06-29

Applicant: COOK INCORPORATED

Inventor： OSBORNE, Thomas, A. ,  BURTON, David, G.

IPC: A61M25/00

CPC classification number: A61M25/008 ,  A61M25/0105 ,  A61M2025/0063 ,  A61M2025/0081

Abstract: An apparatus for percutaneous catheterization. The apparatus comprises a catheter, and an inner cannula received within the lumen of the catheter. The inner cannula has a distal portion that tapers toward the distal end, and is sized to extend through the distal opening of the catheter to provide a generally smooth diametrical transition between the distal end of the catheter and the distal open end of the inner cannula. A stiffening cannula is sized to be received in the lumen of the inner catheter, and has an inner diameter sized to receive a wire guide therethrough. The stiffening cannula as a distal section of greater flexibility than the flexibility of a proximal section for providing kink resistance to the apparatus.

Abstract translation: 一种用于经皮导管插入术的装置。 该装置包括导管和容纳在导管内腔内的内插管。 内套管具有朝向远端逐渐变细的远侧部分，并且其尺寸设计成延伸穿过导管的远端开口，以在导管的远端和内套管的远端开口端之间提供大致平滑的直径过渡。 加强插管的尺寸被设计成容纳在内导管的内腔中，并且具有尺寸适于容纳线引导件的内径。 作为远端部分的加强插管具有比用于向装置提供扭结阻力的近端部分的柔性更大的灵活性。

公开(公告)号：WO2010011843A1

公开(公告)日：2010-01-28

申请号：PCT/US2009/051550

申请日：2009-07-23

Applicant: COOK INCORPORATED ,  AGGERHOLM, Steen ,  BURTON, David, G. ,  BOATMAN, Scott, E. ,  WILLIAM COOK EUROPE APS

Inventor： AGGERHOLM, Steen ,  BURTON, David, G. ,  BOATMAN, Scott, E.

IPC: A61M25/10 ,  A61M29/02 ,  A61M25/00

CPC classification number: A61M25/1029 ,  A61M25/1002 ,  A61M25/1034 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/1086 ,  B29C33/3842 ,  B29C33/42 ,  B29C49/48 ,  B29K2995/0072 ,  B29L2031/7543

Abstract: In at least one embodiment of the present invention a balloon catheter is provided. The balloon catheter comprises a shaft having a lumen formed therethrough. Connected to the shaft is an inflatable balloon. The inflatable balloon has a balloon wall defining a balloon interior surface and a balloon exterior surface that is opposite the interior surface. In fluid communication with the balloon wall is the lumen for inflating the balloon to define an inflated state and for collapsing the balloon to define a deflated state. The balloon wall is textured in the deflated state such that the balloon interior surface is spatially registered with the balloon exterior surface. The balloon in the inflated state is tensioned to have a surface roughness substantially less than a surface roughness of the balloon in the deflated state.

Abstract translation: 在本发明的至少一个实施例中，提供了气囊导管。 气囊导管包括具有从其形成的内腔的轴。 连接到轴是一个充气气球。 可膨胀气囊具有限定球囊内表面的气球壁和与内表面相对的气球外表面。 与球囊壁流体连通是用于使气囊膨胀以限定膨胀状态并用于使气囊折叠以限定放气状态的内腔。 球囊壁在放气状态下被纹理化，使得球囊内表面在空间上与球囊外表面对准。 处于膨胀状态的气囊被张紧以具有基本上小于气囊在收缩状态下的表面粗糙度的表面粗糙度。

公开(公告)号：WO2001019425A1

公开(公告)日：2001-03-22

申请号：PCT/US2000/025258

申请日：2000-09-15

Applicant: COOK INCORPORATED

Inventor： BOATMAN, Scott, E. ,  BURTON, David, G. ,  DREWES, David, A., Jr. ,  HOFFA, Michael, C. ,  HUPCEY, Maggie, A., Z. ,  LESSARD, David, R. ,  OSBORNE, Thomas, A.

IPC: A61L29/06

CPC classification number: C08G69/48 ,  A61L29/06 ,  C08F283/04 ,  C08L77/00 ,  C08F218/16

Abstract: A medical device (10, 110) includes a catheter shaft (11, 111) and can include an expandable balloon (18, 118) and a unitarily and continuously formed portion (108) having a varying durometer. One or both of the unitarily and continuously formed portion (108) and the balloon (18) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant.

Abstract translation: 医疗装置（10,110）包括导管轴（11,111），并且可以包括可膨胀气囊（18,118）和具有变化的硬度的整体连续形成的部分（108）。 整体和连续形成的部分（108）和球囊（18）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。