公开(公告)号：WO2011146729A2

公开(公告)日：2011-11-24

申请号：PCT/US2011/037173

申请日：2011-05-19

Applicant: COOK INCORPORATED ,  COOK BIOTECH INCORPORATED ,  PAUL, Ram, H. ,  STANLEY, Cleon ,  BATES, Brian, L. ,  OBERMILLER, F., Joseph ,  OSBORNE, Thomas, A. ,  CHAMBERS, Sean

Inventor： PAUL, Ram, H. ,  STANLEY, Cleon ,  BATES, Brian, L. ,  OBERMILLER, F., Joseph ,  OSBORNE, Thomas, A. ,  CHAMBERS, Sean

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/3468 ,  A61B2017/00004 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00623 ,  A61B2017/00628 ,  A61B2017/00641 ,  A61B2017/00659 ,  A61B2017/00663 ,  A61B2017/0496 ,  A61B2017/06176

Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Abstract translation: 除此之外，还公开了用于医​​疗密封容器或壁中的开口的装置和方法。 例如，在医疗应用中，提供输送管用于通过护套插入血管（例如血管）中。 固定在细丝上的圆顶状密封件，吸收性和/或可压缩缓冲器以及锁定构件设置在输送管中。 输送管被构造成使得其可以通过护套插入到容器中。 在灯丝上保持张力以将密封件保持在管或鞘上。 护套被拉出，同时拉出管子，将密封件留在血管壁的开口处。 锁定构件将缓冲器压靠在容器的外部，并且灯丝将密封件保持在容器内部的适当位置。

公开(公告)号：WO2010075000A1

公开(公告)日：2010-07-01

申请号：PCT/US2009/067655

申请日：2009-12-11

Applicant: COOK INCORPORATED ,  HOWAT, William, L. ,  OSBORNE, Thomas, A.

Inventor： HOWAT, William, L. ,  OSBORNE, Thomas, A.

IPC: A61M25/00

CPC classification number: A61M25/0054 ,  A61M25/0012 ,  A61M25/005 ,  A61M25/0053 ,  A61M2025/0047

Abstract: An introducer sheath includes a lubricious inner liner having a passageway extending longitudinally therethrough, a reinforcing member positioned over the inner liner, and an outer jacket positioned longitudinally over the reinforcing member and the inner liner. The outer jacket has a higher durometer proximal portion, a lower durometer distal portion, and a transition zone between the proximal portion and the distal portion. The transition zone has a variable durometer from a junction with the outer jacket proximal portion to a junction with the outer jacket distal portion, to provide a transition between the higher durometer proximal portion and the lower durometer distal portion.

Abstract translation: 引导器护套包括具有纵向穿过其延伸的通道的光滑内衬，位于内衬上的加强构件和位于加强构件和内衬之间纵向延伸的外护套。 外护套具有较高的硬度近端部分，较低的硬度计远端部分和近端部分与远端部分之间的过渡区域。 过渡区具有从与外护套近端部分到外护套远端部分的连接处的可变硬度计，以提供较高硬度计近端部分和下部硬度计远端部分之间的转变。

公开(公告)号：WO2006113863A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014864

申请日：2006-04-20

Applicant: COOK INCORPORATED ,  PAL, Dharmendra ,  AGNEW, Charles, W. ,  FLAGLE, Jacob, A. ,  LENTZ, D., Christian ,  MELSHEIMER, Jeffry, S. ,  OSBORNE, Thomas, A. ,  PARKER, Fred, T.

Inventor： PAL, Dharmendra ,  AGNEW, Charles, W. ,  FLAGLE, Jacob, A. ,  LENTZ, D., Christian ,  MELSHEIMER, Jeffry, S. ,  OSBORNE, Thomas, A. ,  PARKER, Fred, T.

CPC classification number: A61M25/0662 ,  A61F2/95 ,  A61F2002/9517 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053

Abstract: Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.

Abstract translation: 提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分 限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。 用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。 外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其他医疗器械通过的后膛位置开口的过渡区域附近。 外部构件相对于内部构件可轴向滑动以展开自扩张装置。 还提供了使用和制造方法。

公开(公告)号：WO2006014383A1

公开(公告)日：2006-02-09

申请号：PCT/US2005/023625

申请日：2005-06-30

Applicant: COOK INCORPORATED ,  AMARANT, Paul, D. ,  OSBORNE, Thomas, A.

Inventor： AMARANT, Paul, D. ,  OSBORNE, Thomas, A.

IPC: A61F2/06

CPC classification number: A61F2/90 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078 ,  A61F2250/0037 ,  A61F2250/0039

Abstract: Stents 10 are provided having a circumferential element 15 with first and second ends 11, 12, a longitudinal axis 14, and arcuate struts 20 disposed intermediate the ends. End portions 22, 23 of adjacent arcuate struts are joined by strut connections 30, 31, 31', 33, 35, 36, 38 formed at the first and second ends. The struts are spaced 60, 62, 64, 70, 72, 74 arcuately relative to a plane 14' that includes the longitudinal axis, such that they arc convexly 25 or concavely 24 relative to the plane. Another stent 110 has a tubular main body with a longitudinal axis 14, first and second ends 111, 112 defining a lumen 13 in communication with openings 17, 18 at the first and second ends, and circumferential elements 15 disposed along the tubular main body longitudinal axis, whereby one or more link members 16 join two or more of the circumferential elements. Methods 100 of using a stent having a circumferential element having arcuate struts connected by strut connections are also provided.

Abstract translation: 提供具有圆周元件15的支架10，其具有第一和第二端部11,12，纵向轴线14和设置在端部中间的弓形支柱20。 相邻弓形支柱的端部22,23通过形成在第一端和第二端的支柱连接件30,31,31'，33,35,36,38连接起来。 支柱相对于包括纵向轴线的平面14'间隔开60,62,64,70,72,74，使得它们相对于该平面凸出25°或凹入24°。 另一个支架110具有带纵向轴线14的管状主体，第一和第二端部111,112限定与第一和第二端部处的开口17,18相连通的管腔13，以及沿管状主体纵向 由此一个或多个连杆构件16连接两个或更多个周向元件。 还提供了使用具有通过支柱连接连接的具有弓形支柱的圆周元件的支架的方法100。

公开(公告)号：WO2005034810A1

公开(公告)日：2005-04-21

申请号：PCT/US2004/033570

申请日：2004-10-12

Applicant: COOK INCORPORATED ,  OSBORNE, Thomas, A.

Inventor： OSBORNE, Thomas, A.

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/061 ,  A61F2002/075 ,  A61F2002/821

Abstract: A prosthesis (10) having a variable size or stretchable fenestration (14) in the graft material (37) of a biocompatible tubular graft (11). An expandable frame (16) is disposed about the fenestration, and a portion (17) of the graft material about the fenestration is folded back over the frame to cover the frame. Additional grafts or prosthesis of varying size can be inserted through the frame and fenestration with the stretched frame and folded portion compressing on the inserted graft forming a seal therewith.

Abstract translation: 在生物相容的管状移植物（11）的移植材料（37）中具有可变尺寸或可拉伸的开窗（14）的假体（10）。 围绕开窗设置可膨胀框架（16），围绕开窗的移植材料的一部分（17）被折回到框架上以覆盖框架。 可以通过框架插入不同尺寸的附加移植物或假体，并用拉伸的框架进行开窗，并且在插入的移植物上的折叠部分压缩形成与其的密封。

公开(公告)号：WO2005004967A2

公开(公告)日：2005-01-20

申请号：PCT/US2004/020934

申请日：2004-06-29

Applicant: COOK INCORPORATED

Inventor： OSBORNE, Thomas, A. ,  BURTON, David, G.

IPC: A61M25/00

CPC classification number: A61M25/008 ,  A61M25/0105 ,  A61M2025/0063 ,  A61M2025/0081

Abstract: An apparatus for percutaneous catheterization. The apparatus comprises a catheter, and an inner cannula received within the lumen of the catheter. The inner cannula has a distal portion that tapers toward the distal end, and is sized to extend through the distal opening of the catheter to provide a generally smooth diametrical transition between the distal end of the catheter and the distal open end of the inner cannula. A stiffening cannula is sized to be received in the lumen of the inner catheter, and has an inner diameter sized to receive a wire guide therethrough. The stiffening cannula as a distal section of greater flexibility than the flexibility of a proximal section for providing kink resistance to the apparatus.

Abstract translation: 一种用于经皮导管插入术的装置。 该装置包括导管和容纳在导管内腔内的内插管。 内套管具有朝向远端逐渐变细的远侧部分，并且其尺寸设计成延伸穿过导管的远端开口，以在导管的远端和内套管的远端开口端之间提供大致平滑的直径过渡。 加强插管的尺寸被设计成容纳在内导管的内腔中，并且具有尺寸适于容纳线引导件的内径。 作为远端部分的加强插管具有比用于向装置提供扭结阻力的近端部分的柔性更大的灵活性。

公开(公告)号：WO2004017866A1

公开(公告)日：2004-03-04

申请号：PCT/US2003/026042

申请日：2003-08-20

Applicant: COOK INCORPORATED ,  WILLIAM A. COOK AUSTRALIA PTY. LTD. ,  WILLIAM COOK EUROPE ApS

Inventor： COOK, William, A. ,  OSBORNE, Thomas, A. ,  ANDERSON, Sarah, E. ,  HARTLEY, David, Ernest

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: Disclosed is a stent graft prosthesis (10) comprising a graft portion (11) that includes a main body portion (12) and an cuff portion (15), the cuff portion generally located at or near the proximal end (13) of the main body portion and extending circumferentially therealong. Stents comprising the graft suppporting structure (40) are also attached to graft portion about the proximal end. In one embodiment, the cuff portion comprises material (38) that is folded over the outside surface (39) of the main body portion with an anchoring stent (18) being attached over the cuff and main body portions, extending proximally therefrom. In another series of embodiments, the cuff portion comprises an external sealing zone (21) that extends around the outer main body portion to help prevent leakage of fluids. In one example, the material of the second edge of the cuff portion comprises a frayed portion (22) to better engage the vessel walls and promote thrombus and/or tissue growth.

Abstract translation: 公开了一种包括移植部分（11）的支架移植物假体（10），其包括主体部分（12）和袖带部分（15），所述袖带部分大致位于主体部分（13）的近端（13）处或附近 主体部分并沿其周向延伸。 包括移植物支撑结构（40）的支架也在近端附接到移植部分。 在一个实施例中，袖带部分包括折叠在主体部分的外表面（39）上的材料（38），其中锚定支架（18）附接在袖带和主体部分上，从其向近侧延伸。 在另一系列实施例中，袖带部分包括围绕外主体部分延伸的外部密封区域（21），以帮助防止流体泄漏。 在一个示例中，袖带部分的第二边缘的材料包括磨损部分（22），以更好地接合血管壁并促进血栓和/或组织生长。

公开(公告)号：WO2004016200A1

公开(公告)日：2004-02-26

申请号：PCT/US2003/025794

申请日：2003-08-15

Applicant: COOK INCORPORATED ,  OREGON HEALTH AND SCIENCE UNIVERSITY ,  MED INSTITUTE, INC. ,  WILLIAM COOK EUROPE ApS

Inventor： PAVCNIK, Dusan ,  CASE, Brian, L. ,  FLAGLE, Jacob, A. ,  GARRISON, Mike ,  HOFFA, Andrew, K. ,  LEONARD, Raymond, B., II ,  OSBORNE, Thomas, A. ,  PAUL, Ram, H., Jr. ,  SCHAEFFER, Darin, G. ,  SISKEN, Richard, B.

IPC: A61F2/06

CPC classification number: C25F3/24 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/001 ,  A61F2230/0023 ,  A61F2230/0026 ,  A61F2230/0054 ,  A61F2230/0058 ,  A61F2230/0091 ,  A61F2230/0095

Abstract: A valve prosthesis (43), such as an artificial venous valve, having a support frame (11) and leaf structure comprising one or more leaflets (78, 79) in which the outer edge (112) of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements (31, 32) can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure (164) comprises a second or third expandable frames (31, 32) attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

Abstract translation: 具有支撑框架（11）和叶结构的瓣膜假体（43），例如人造静脉瓣，叶片结构包括一个或多个传单（78,79），其中每个小叶的外边缘（112） 沿着蛇形路径的身体通道通过可扩张的框架被推靠在通道上，而内边缘响应于流体而移动以限制逆行流动。 可选地，一个或多个元件（31,32）可以从支撑框架/叶片结构延伸，以提供定位支撑和/或保护免受附着在血管壁上的小叶。 在一个实施例中，定心支撑结构（164）包括附接到主阀结构和支撑框架的近端和/或远端并从其延伸的第二或第三可膨胀框架（31,32）。 在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

公开(公告)号：WO2010024881A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/004830

申请日：2009-08-25

Applicant: MED INSTITUTE, INC. ,  WILLIAM COOK EUROPE ApS ,  COOK INCORPORATED ,  DIERKING, William, K. ,  ROEDER, Blayne, A. ,  ORR, David, E. ,  OEHLENSCHLAEGER, Bent ,  RASMUSSEN, Erik, E. ,  HARDERT, Michael, W. ,  OSBORNE, Thomas, A. ,  URBANSKI, Julie, E.

Inventor： DIERKING, William, K. ,  ROEDER, Blayne, A. ,  ORR, David, E. ,  OEHLENSCHLAEGER, Bent ,  RASMUSSEN, Erik, E. ,  HARDERT, Michael, W. ,  OSBORNE, Thomas, A. ,  URBANSKI, Julie, E.

IPC: A61F2/82

CPC classification number: A61F2/064 ,  A61F2/07 ,  A61F2/848 ,  A61F2/86 ,  A61F2002/8483 ,  A61F2220/0016

Abstract: An endoluminal prosthesis includes a support structure comprising a curvilinear portion having a first strut and a second strut that meet at an apex. Disposed on the support structure is an anchor (25) with an anchor body and one or more barbs (21) extending outwardly from the anchor body. The anchor body fits at least partially about, and conforms to the first strut, second strut, and the apex.

Abstract translation: 腔内假体包括支撑结构，其包括具有第一支柱的曲线部分和在顶点相遇的第二支柱。 设置在支撑结构上的是具有锚固体的锚固件（25）和从锚固体向外延伸的一个或多个倒钩（21）。 锚身体至少部分地配合在第一支柱，第二支柱和顶点上，并且符合第一支柱。

公开(公告)号：WO2007076114A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/049240

申请日：2006-12-22

Applicant: COOK INCORPORATED ,  OSBORNE, Thomas, A.

Inventor： OSBORNE, Thomas, A.

CPC classification number: A61F2/95 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2002/9665

Abstract: A trigger wire release mechanism is disclosed that includes a control member for selectively releasing a trigger wire (22, 44) from a prosthesis retaining device. The control member includes an elongate body member (36) and a guide member (24, 25, 93, 94) slidably disposed on the elongate body member. The trigger wire 1 (22, 44) includes a distal end coupled to the prosthesis retaining device and a proximal end coupled to the guide member. The guide member (24, 25, 93, 94) can lbe moved from a distal end of the elongate body (36) to a proximal end of the elongate body, thereby disengaging the trigger wire (22, 44) from the retaining device. The control member may include a locking mechanism (120) for limiting the axial position of the guide member (24, 25, 93, 94) along the elongate body member (36). A prosthesis control member (81) is also disclosed. The prosthesis control member (81) is adapted to control the position of the prosthesis during deployment.

Abstract translation: 公开了一种触发线释放机构，其包括用于从假体保持装置选择性地释放触发线（22,44）的控制构件。 控制构件包括细长主体构件（36）和可滑动地设置在细长主体构件上的引导构件（24,25,93,94）。 触发线1（22,44）包括联接到假体保持装置的远端和联接到引导构件的近端。 引导构件（24,25,93,94）可以从细长体（36）的远端移动到细长体的近端，从而使触发线（22,44）与保持装置分离。 控制构件可以包括用于限制引导构件（24,25,93,94）沿着细长主体构件（36）的轴向位置的锁定机构（120）。 还公开了假体控制构件（81）。 假体控制构件（81）适于在展开期间控制假体的位置。