公开(公告)号：WO2015148931A1

公开(公告)日：2015-10-01

申请号：PCT/US2015/023008

申请日：2015-03-27

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  DOW AGROSCIENCES LLC

Inventor： HANLEY, Patrick S. ,  WHITEKER, Gregory T. ,  OBER, Matthias S. ,  KRUPER, Jr. ,  KRASOVSKIY, Arkady L.

IPC: C07B37/04

CPC classification number: C07C1/322 ,  C07B37/04 ,  C07C1/321 ,  C07C15/14 ,  C07C17/263 ,  C07C22/04 ,  C07C22/08 ,  C07C41/30 ,  C07C45/70 ,  C07C67/343 ,  C07C211/45 ,  C07C231/12 ,  C07C233/00 ,  C07C253/30 ,  C07C2531/22 ,  C07C2531/24 ,  C07C2531/28 ,  C07D213/127 ,  C07D213/16 ,  C07D263/54 ,  C07C233/65 ,  C07C255/50 ,  C07C43/205 ,  C07C49/784 ,  C07C69/76

Abstract: In one aspect, there is provided a method of coupling a first aromatic compound having a fluorosulfonate substituent to a second aromatic compound having a boron-containing substituent. In another aspect, there is provided a method of coupling a first aromatic compound having a hydroxyl substituent to a second aromatic compound having a boron-containing substituent in a one-pot reaction.

Abstract translation: 一方面，提供了将具有氟磺酸盐取代基的第一芳香族化合物与具有含硼取代基的第二芳香族化合物结合的方法。 在另一方面，提供了在一锅反应中将具有羟基取代基的第一芳族化合物与具有含硼取代基的第二芳族化合物偶联的方法。

公开(公告)号：WO2017127794A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014532

申请日：2017-01-23

Applicant: DOW AGROSCIENCES LLC

Inventor： STOCKMAN, Kenneth E. ,  WHITEKER, Gregory T. ,  MOLITOR, Erich J. ,  CHOY, Nakyen

IPC: A01N43/40 ,  A01N37/34 ,  C07D213/00 ,  C07D213/84 ,  C07D405/00

CPC classification number: C07D213/84 ,  C07D213/79

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.

Abstract translation: 4-烷氧基-3-羟基吡啶甲酸可由4,6-二溴-3-羟基吡啶-2-甲腈以一系列选自溴取代，腈水解和卤素还原的化学步骤方便地制备， 一锅煮过程。 4,6-二溴-3-羟基吡啶-2-腈可以从一系列选自氰基胺化，胺盐形成和溴化重排的化学步骤中由糠醛制备。

公开(公告)号：WO2017127791A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014527

申请日：2017-01-23

Applicant: DOW AGROSCIENCES LLC

Inventor： WHITEKER, Gregory T. ,  BORROMEO, Peter ,  LI, Fangzheng ,  ROTH, Gary

IPC: C07D213/803 ,  A01N43/40 ,  C07D213/79

CPC classification number: C07D213/803 ,  C07D213/79

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-acetoxypicolinic acids may be conveniently prepared from 4-alkoxy-3-hydroxypicolinic acids by treatment with acetic anhydride.

Abstract translation: 4-烷氧基-3-羟基吡啶甲酸可由4,6-二溴-3-羟基吡啶-2-甲腈以一系列选自溴取代，腈水解和卤素还原的化学步骤方便地制备， 一锅煮过程。 4,6-二溴-3-羟基吡啶-2-腈可以从一系列选自氰基胺化，胺盐形成和溴化重排的化学步骤中由糠醛制备。 4-烷氧基-3-乙酰氧基吡啶甲酸可以通过用乙酸酐处理由4-烷氧基-3-羟基吡啶甲酸方便地制备。

公开(公告)号：WO2014093591A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/074604

申请日：2013-12-12

Applicant: DOW AGROSCIENCES LLC ,  JOHNSON, Peter Lee ,  RENGA, James M. ,  GIAMPIETRO, Natalie C. ,  WHITEKER, Gregory T. ,  GALLIFORD, Christopher

Inventor： JOHNSON, Peter Lee ,  RENGA, James M. ,  GIAMPIETRO, Natalie C. ,  WHITEKER, Gregory T. ,  GALLIFORD, Christopher

IPC: A01N43/40

CPC classification number: C07D213/74 ,  C07C251/12 ,  C07D213/73 ,  C07D251/12 ,  Y02P20/55

Abstract: 4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6-(substituted)picolinates. More particularly, provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6- (substituted)picolinates from a non-pyridine source. These picolinates are useful as herbicides.

Abstract translation: 4-氨基-3-氯-6-（取代的）吡啶甲酸盐由二氟乙酸或三氟乙酸，三苯甲基胺或叔丁胺作为保护基团制备，3,3-二烷氧基丙-1-炔和取代的亚甲基胺 一系列步骤。 本文提供了制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐和4-氨基-3-卤代-6-（取代的）吡啶甲酸盐的方法。 更具体地，本文提供的是从非吡啶源制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐和4-氨基-3-卤代-6-（取代的）吡啶甲酸盐的方法 。 这些吡啶甲酸盐作为除草剂是有用的。

公开(公告)号：WO2016022623A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/043707

申请日：2015-08-05

Applicant: DOW AGROSCIENCES LLC

Inventor： GRANDBOIS, Matthew L. ,  LAITAR, David S. ,  RENGA, James M. ,  WHITEKER, Gregory T.

IPC: C07D213/79

CPC classification number: C07D213/803 ,  B01J31/1815 ,  B01J2531/847

Abstract: 4,5,6-Trichloropicolinic acid is prepared by selectively dechlonnating 3,4,5,6- tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent. A process for the preparation of 4,5,6-trichloro-picolinic acid by the regioselective reductive dechlorination of 3,4,5,6-tetrachloropicolinic acid is provided. More particularly, the process is described for the preparation of 4,5,6-trichloropicolinic acid (Formula I) which comprises selectively dechlonnating 3,4,5,6-tetrachloropicolinic acid (Formula II) with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent.

Abstract translation: 通过选择性地将3,4,5,6-四氯吡啶甲酸与锌和由极性溶剂中的镍化合物和二齿配体制备的催化剂进行选择性脱除制备4,5,6-三氯吡啶甲酸。 提供了通过区域选择性还原脱氯3,4,5,6-四氯吡啶甲酸制备4,5,6-三氯吡啶甲酸的方法。 更具体地，描述了用于制备4,5,6-三氯吡啶甲酸（式I）的方法，其包括选择性地使3,4,5,6-四氯吡啶甲酸（式II）与锌和由镍制备的催化剂 化合物和二齿配体在极性溶剂中。

公开(公告)号：WO2016007634A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039565

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  CHOY, Nakyen ,  STOCKMAN, Kenneth E.

IPC: A61K31/535

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。 4-烷氧基-3-羟基吡啶甲酸可以从选自溴取代，腈水解和卤素还原的一系列化学步骤中方便地从4,6-二溴-3-羟基吡啶腈制备。

公开(公告)号：WO2014160031A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/025674

申请日：2014-03-13

Applicant: DOW AGROSCIENCES LLC

Inventor： FISCHER, Lindsey G. ,  BAUM, Erich W. ,  CROUSE, Gary D. ,  DEAMICIS, Carl ,  LORSBACH, Beth ,  PETKUS, Jeff ,  SPARKS, Thomas C. ,  WHITEKER, Gregory T. ,  WARD, Andrew L. ,  ROSS, Ronald ,  HAO, Yan ,  GIAMPIETRO, Natalie C.

IPC: C07D401/00 ,  A61K31/4196 ,  A01N43/647 ,  A01P7/00 ,  A01P9/00 ,  A01P19/00

CPC classification number: C07D417/12 ,  A01N25/00 ,  A01N25/32 ,  A01N43/653 ,  A01N47/12 ,  A01N47/34 ,  A01N47/36 ,  A01N47/40 ,  A01N47/42 ,  A01N53/00 ,  A01N55/08 ,  C07C211/45 ,  C07C267/00 ,  C07C335/02 ,  C07C335/16 ,  C07C335/26 ,  C07D249/08 ,  C07D277/54 ,  C07D285/01 ,  C07D403/10 ,  C07D405/10 ,  C07F5/04

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (Formula One).

Abstract translation: 本公开涉及具有杀虫效果的分子领域，用于在线虫线虫，节肢动物和/或软体动物中的害虫，产生这种分子的方法和用于此类方法的中间体，含有这种分子的组合物，以及使用这种分子对这种害虫 。 这些分子可以用作例如杀线虫剂，杀螨剂，杀虫剂，杀螨剂和/或杀软体动物剂。 该文献公开了具有下式（式1）的分子。

公开(公告)号：WO2014158649A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/019053

申请日：2014-02-27

Applicant: DOW AGROSCIENCES LLC

Inventor： GIAMPIETRO, Natalie C. ,  CROUSE, Gary D. ,  WHITEKER, Gregory T.

IPC: A01N43/653 ,  C07D249/08

CPC classification number: A01N43/653 ,  C07D249/08

Abstract: The invention in this document is related to the field of preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles and certain intermediates derived therefrom, where said intermediates are useful in the preparation of certain pesticides disclosed in U.S. Patent No. 8,178,658.

Abstract translation: 本文中的发明涉及1,3-（取代 - 二芳基）-1,2,4-三唑及其衍生的某些中间体的制备领域，其中所述中间体可用于制备美国公开的某些农药 专利号8,178,658。

公开(公告)号：WO2012103041A3

公开(公告)日：2012-08-02

申请号：PCT/US2012/022285

申请日：2012-01-24

Applicant: DOW AGROSCIENCES LLC ,  ARNDT, Kim E. ,  RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  LOWE, Christian T.

Inventor： ARNDT, Kim E. ,  RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  LOWE, Christian T.

IPC: A01N43/40

Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted) picolinates are conveniently prepared from 3,4;5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling. The present invention concerns a process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates. More particularly, the present invention concerns a process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates in which the 5-fluoro substituent is introduced by a halogen exchange early in the process scheme.

公开(公告)号：WO2018009618A1

公开(公告)日：2018-01-11

申请号：PCT/US2017/040841

申请日：2017-07-06

Applicant: DOW AGROSCIENCES LLC

Inventor： WHITEKER, Gregory T. ,  CHOY, Nakyen ,  BORROMEO, Peter ,  BABIJ, Nicholas R. ,  ROTH, Gary ,  HANLEY, Patrick S. ,  OBER, Matthias S. ,  STATON, Tina ,  KNUEPPEL, Daniel I. ,  WALD, Grant Von ,  HOUGH, Nicole

IPC: A01N37/44 ,  A01N43/34 ,  A01N47/12

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

Abstract translation: 可以在包括4-甲氧基-3-乙酰氧基吡啶甲酸或4-甲氧基-3-羟基吡啶甲酸与键2一起偶联的过程中方便地制备杀真菌4-甲氧基-3-乙酰氧基吡啶酰胺 - 氨基丙酸酯衍生自1,1-双（4-氟苯基）丙烷-1,2-二醇。