公开(公告)号：WO2006019355A1

公开(公告)日：2006-02-23

申请号：PCT/SE2005/001215

申请日：2005-08-17

Applicant: DOXA AB

Inventor： ENGQVIST, Håkan ,  HERMANSSON, Leif ,  LÖÖF, Jesper ,  SPENGLER, Håkan

IPC: A61K6/06

CPC classification number: A61L27/42 ,  A61K6/0008 ,  A61K6/0085 ,  A61K6/0091 ,  A61K6/0612 ,  A61K6/0643 ,  A61K6/0668 ,  A61K6/0675 ,  A61L27/105 ,  C04B28/02 ,  C04B28/06 ,  C04B28/34 ,  C04B2111/00836 ,  C04B20/0048 ,  C04B24/2641 ,  C04B14/42 ,  A61K6/083 ,  C08L33/08

Abstract: A system for a chemically bonded ceramic material (CBC), comprising a composite biomaterial for preferably dental and/or orthopaedic applications. The CBC-system includes a binding (chemical cement) and inert phases with specified geometry provid-ing the biomaterial defect tolerance through an improved fracture toughness. The in-vention also relates to the powdered materials and the hydration liquid, respectively, as well as the formed ceramic material.

Abstract translation: 一种用于化学结合的陶瓷材料（CBC）的系统，其包括用于优选牙科和/或矫形应用的复合生物材料。 CBC系统包括具有特定几何结构（化学水泥）和惰性相，通过改进的断裂韧性提供生物材料缺陷耐受性。 本发明还涉及粉末材料和水合液体以及形成的陶瓷材料。

公开(公告)号：WO2005053764A1

公开(公告)日：2005-06-16

申请号：PCT/SE2004/001745

申请日：2004-11-25

Applicant: DOXA AB ,  HERMANSSON, Leif ,  ENGQVIST, Håkan ,  LÖÖF, Jesper

Inventor： HERMANSSON, Leif ,  ENGQVIST, Håkan ,  LÖÖF, Jesper

IPC: A61L27/30

CPC classification number: A61L27/306 ,  A61K6/0631 ,  B82Y30/00 ,  C04B35/22 ,  C04B35/44 ,  C04B41/009 ,  C04B41/5024 ,  C04B41/5032 ,  C04B41/85 ,  C04B2111/00836 ,  C04B2235/3205 ,  C04B2235/781 ,  C04B35/10 ,  C04B35/48

Abstract: The present invention relates to a coated implant for in vivo-anchoring of implants to a biological tissue or another implant, which coated implant comprises an implant having a pre-treated surface and on said pre-treated surface one or more layers of ceramic material chemically and/or mechanically bound to said pre-treated surface. Said one or more layers comprises mainly non-hydrated chemically bonded ceramic material, and each layer independently comprises a first binder phase selected from the group consisting of aluminates, silicates, phosphates, sulphates and combinations thereof. The invention further relates to method of manufacturing said coated implant, a ceramic paste and to a kit comprising said coated implant and ceramic paste. The invention is particularly suitable for dental and orthopaedic implants.

Abstract translation: 本发明涉及用于将植入物体内锚定到生物组织或另一种植入物上的涂层植入物，该涂层植入物包括具有预处理表面的植入物和所述预处理表面上的植入物 一层或多层陶瓷材料化学地和/或机械地结合到所述预处理过的表面上。 所述一个或多个层主要包含非水合的化学键合的陶瓷材料，并且各层独立地包含选自铝酸盐，硅酸盐，磷酸盐，硫酸盐及其组合的第一粘结相。 本发明进一步涉及制造所述涂覆的植入物的方法，陶瓷膏以及包括所述涂覆的植入物和陶瓷膏的套件。 本发明特别适用于牙科和整形外科植入物。

公开(公告)号：WO2011043707A1

公开(公告)日：2011-04-14

申请号：PCT/SE2009/051135

申请日：2009-10-09

Applicant: DOXA AB ,  HERMANSSON, Leif ,  LÖÖF, Jesper ,  FARIS, Adam

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  FARIS, Adam

IPC: A61L24/00 ,  A61L27/10 ,  A61L27/44 ,  A61K6/06 ,  C04B24/04 ,  C04B28/00

CPC classification number: A61L27/446 ,  A61K6/0205 ,  A61K6/0835 ,  A61L24/0089 ,  A61L27/10 ,  C04B28/06 ,  C04B2111/00836 ,  C04B7/02 ,  C04B14/22 ,  C04B20/008 ,  C04B22/124 ,  C04B24/04 ,  C04B24/2641

Abstract: The present invention generally relates to chemically bonded ceramic biomaterials, preferably a dental material or an implant material, comprising two binder systems. The main binder system forms a chemically bonded ceramic upon hydration thereof, and comprises powdered calcium aluminate and, optionally, minor amounts of calcium silicate. The second binder system is a cross-linking organic binder system which provides for initial crosslinking of the freshly mixed paste forming the biomaterial. The biomaterial also comprises inert filler particles. The inventive biomaterial is free from reactive glass and thus provides for a simplified two binder systems biomaterial with a reduced number of required reactive components The invention relates to a powdered composition for preparing the inventive chemically bonded ceramic biomaterial, and a paste from which the biomaterial is formed, as well as a kit comprising the powdered composition and hydration liquid, as well as methods and use of the biomaterial in dental and implant applications.

Abstract translation: 本发明通常涉及化学结合的陶瓷生物材料，优选牙科材料或植入材料，其包含两种粘合剂体系。 主要的粘合剂体系在水合时形成化学键合的陶瓷，并且包括粉末状的铝酸钙和任选地少量的硅酸钙。 第二粘合剂系统是交联的有机粘合剂体系，其提供形成生物材料的新混合糊料的初始交联。 生物材料还包括惰性填料颗粒。 本发明的生物材料不含活性玻璃，因此提供了一种具有减少数量的所需反应性组分的简化的两种粘合剂体系生物材料。本发明涉及用于制备本发明化学键合的陶瓷生物材料的粉末组合物，以及生物材料 形成，以及包含粉末状组合物和水合液体的试剂盒，以及生物材料在牙齿和植入物应用中的方法和用途。

公开(公告)号：WO2011040851A1

公开(公告)日：2011-04-07

申请号：PCT/SE2009/051097

申请日：2009-10-02

Applicant: DOXA AB ,  HERMANSSON, Leif ,  LÖÖF, Jesper ,  GLANTZ, Per-Olof ,  ABRAHAMSSON, Emil

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  GLANTZ, Per-Olof ,  ABRAHAMSSON, Emil

IPC: A61L27/30 ,  A61K6/06 ,  C04B7/32 ,  C04B41/52

CPC classification number: A61C8/0006 ,  A61C8/0013 ,  A61K6/0612 ,  A61K6/0637 ,  A61L27/30 ,  C04B28/06 ,  C04B41/009 ,  C04B41/508 ,  C04B41/85 ,  C04B2111/00215 ,  C04B2111/00836 ,  C04B7/02 ,  C04B14/22 ,  C04B22/0053 ,  C04B22/124 ,  C04B2103/0086 ,  C04B14/30 ,  C04B24/06 ,  C04B35/10 ,  C04B35/00 ,  C04B35/48

Abstract: The present invention relates to a calcium aluminate based paste forming a chemically bonded biomaterial on hydration thereof for in vivo anchoring of new implants, or stabilizing of existing implants in situ to an adjacent bone tissue, which paste provides a controlled pH value and temperature as well as initial hardening time. By virtue of the pH value and temperature the paste exhibits antibacterial and/or bacteriostatic properties. The present invention also relates to a method of preparing implants to be implanted wherein the implant is coated with the paste, a method of implanting a coated implant, as well as methods of preventing and treating implant related conditions, such as periimplantitis, and a kit for preparing the paste. The invention is especially intended for re-stabilization of dental implants, and implantation into low quality bone tissue.

Abstract translation: 本发明涉及一种在其水化时形成化学键合的生物材料的铝酸钙基糊料，用于新植入物的体内锚定，或将现有植入物原位稳定到相邻的骨组织，该糊还提供受控的pH值和温度 作为初始硬化时间。 由于pH值和温度，糊状物具有抗细菌和/或抑菌特性。 本发明还涉及一种制备待植入植入物的方法，其中所述植入物涂覆有所述浆料，植入涂覆的植入物的方法，以及预防和治疗植入物相关病症（例如周边炎）和试剂盒 用于制备糊状物。 本发明特别用于牙科植入物的再稳定化和植入低品质骨组织中。

公开(公告)号：WO2009025599A1

公开(公告)日：2009-02-26

申请号：PCT/SE2007/050574

申请日：2007-08-23

Applicant: DOXA AB ,  HERMANSSON, Leif ,  LÖÖF, Jesper ,  ENGQVIST, Håkan

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  ENGQVIST, Håkan

IPC: A61K6/06

CPC classification number: A61K6/0008 ,  A61K6/0023 ,  A61K6/0631 ,  A61K6/0675 ,  C08L33/08 ,  A61K6/0835

Abstract: A dental cement system, comprising an aqueous hydration liquid and a powdered material that essentially consists of an inorganic cement system, which powdered material has the capacity to form a complex, chemically bonded material with inorganic as well as organic phases with properties suitable for cementation of implant to another implant and/or to tooth or bone tissue. The invention relates to the powdered material and the hydration liquid, respectively, as well as the formed ceramic material and a kit comprising the system.

Abstract translation: 一种牙科水泥系统，包括水性水合液体和基本上由无机水泥体系组成的粉末材料，该粉末材料具有与无机和有机相形成复合化学键合的材料的能力，其特性适合于 植入到另一植入物和/或牙齿或骨组织。 本发明分别涉及粉末材料和水合液体，以及形成的陶瓷材料和包括该系统的试剂盒。