公开(公告)号：WO2008008184A3

公开(公告)日：2009-03-19

申请号：PCT/US2007014953

申请日：2007-06-27

Applicant: DENTSPLY INT INC ,  PRIMUS CAROLYN M ,  GUTMANN JAMES L

Inventor： PRIMUS CAROLYN M ,  GUTMANN JAMES L

IPC: A61K6/00

CPC classification number: A61K6/0637 ,  A61K6/0088 ,  A61K6/0091 ,  A61K6/0094 ,  A61K6/0612 ,  A61K6/0681 ,  A61K6/0038 ,  C08L7/00 ,  C08L23/20 ,  A61K6/083

Abstract: Improved compositions comprising a mixture of gutta-percha and a hydraulic material containing calcium silicate, calcium aluminate, calcium phosphate, and calcium sulfate compounds are provided. Preferably, the composition includes hydroxylapatite mineral. The composition is particularly suitable for obturating and sealing dental root canals. The composition should provide a stable barrier to bacterial and fluid leakage in the root canal system of a tooth. In addition, the composition should help promote the growth of new bone and tissue surrounding the root tip area.

Abstract translation: 提供了包含gutta-percha和含有硅酸钙，铝酸钙，磷酸钙和硫酸钙化合物的水硬材料的混合物的改进的组合物。 优选地，组合物包括羟基磷灰石矿物。 该组合物特别适用于牙根管灌封和密封。 组合物应为牙根管系统中的细菌和液体渗漏提供稳定的屏障。 此外，组合物应有助于促进根尖周围区域的新骨骼和组织的生长。

公开(公告)号：WO2011040851A1

公开(公告)日：2011-04-07

申请号：PCT/SE2009/051097

申请日：2009-10-02

Applicant: DOXA AB ,  HERMANSSON, Leif ,  LÖÖF, Jesper ,  GLANTZ, Per-Olof ,  ABRAHAMSSON, Emil

Inventor： HERMANSSON, Leif ,  LÖÖF, Jesper ,  GLANTZ, Per-Olof ,  ABRAHAMSSON, Emil

IPC: A61L27/30 ,  A61K6/06 ,  C04B7/32 ,  C04B41/52

CPC classification number: A61C8/0006 ,  A61C8/0013 ,  A61K6/0612 ,  A61K6/0637 ,  A61L27/30 ,  C04B28/06 ,  C04B41/009 ,  C04B41/508 ,  C04B41/85 ,  C04B2111/00215 ,  C04B2111/00836 ,  C04B7/02 ,  C04B14/22 ,  C04B22/0053 ,  C04B22/124 ,  C04B2103/0086 ,  C04B14/30 ,  C04B24/06 ,  C04B35/10 ,  C04B35/00 ,  C04B35/48

Abstract: The present invention relates to a calcium aluminate based paste forming a chemically bonded biomaterial on hydration thereof for in vivo anchoring of new implants, or stabilizing of existing implants in situ to an adjacent bone tissue, which paste provides a controlled pH value and temperature as well as initial hardening time. By virtue of the pH value and temperature the paste exhibits antibacterial and/or bacteriostatic properties. The present invention also relates to a method of preparing implants to be implanted wherein the implant is coated with the paste, a method of implanting a coated implant, as well as methods of preventing and treating implant related conditions, such as periimplantitis, and a kit for preparing the paste. The invention is especially intended for re-stabilization of dental implants, and implantation into low quality bone tissue.

Abstract translation: 本发明涉及一种在其水化时形成化学键合的生物材料的铝酸钙基糊料，用于新植入物的体内锚定，或将现有植入物原位稳定到相邻的骨组织，该糊还提供受控的pH值和温度 作为初始硬化时间。 由于pH值和温度，糊状物具有抗细菌和/或抑菌特性。 本发明还涉及一种制备待植入植入物的方法，其中所述植入物涂覆有所述浆料，植入涂覆的植入物的方法，以及预防和治疗植入物相关病症（例如周边炎）和试剂盒 用于制备糊状物。 本发明特别用于牙科植入物的再稳定化和植入低品质骨组织中。

公开(公告)号：WO2008100452A2

公开(公告)日：2008-08-21

申请号：PCT/US2008/001759

申请日：2008-02-08

Applicant: DENTSPLY INTERNATIONAL INC. ,  BREUER, Miklos, M. ,  PRIMUS, Carolyn, M. ,  GUTMANN, James, L.

Inventor： PRIMUS, Carolyn, M. ,  GUTMANN, James, L.

IPC: A61K6/00

CPC classification number: A61K6/0038 ,  A61K6/0032 ,  A61K6/0067 ,  A61K6/007 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/033 ,  A61K6/06 ,  A61K6/0612 ,  A61K6/0637 ,  A61K6/0675 ,  A61K6/0681 ,  A61K6/083 ,  A61K6/0835 ,  A61K6/0035 ,  C08L39/06 ,  C08L29/04 ,  C08L31/04 ,  C08L33/08 ,  C08L33/10 ,  C08L33/14

Abstract: Improved compositions for treating dental pulp and root canals comprising a mixture of particulate materials with water-based liquids containing polyvinyl pyrrolidone are provided. Homopolymers and copolymers of polyvinyl pyrrolidone can be used. Optionally, the composition may contain surfactants, humecatants, stabilizers, and other additives. Examples of particulate powders include mixtures of calcium silicate, calcium aluminate, calcium sulfate, and hydroxyapatite. The compositions are particularly suitable for sealing and obturating dental root canals and root apices. The composition provides a stable barrier to bacterial and fluid leakage in the root canal system of a tooth.

Abstract translation: 提供了用于治疗牙髓和根管的改进的组合物，其包括颗粒材料与含有聚乙烯吡咯烷酮的水性液体的混合物。 可以使用聚乙烯吡咯烷酮的均聚物和共聚物。 任选地，所述组合物可以含有表面活性剂，神经迟缓剂，稳定剂和其它添加剂。 颗粒粉末的实例包括硅酸钙，铝酸钙，硫酸钙和羟基磷灰石的混合物。 该组合物特别适用于密封和填充牙根管和根尖。 该组合物为牙根管系统中的细菌和流体泄漏提供了稳定的屏障。

公开(公告)号：WO2008100451A2

公开(公告)日：2008-08-21

申请号：PCT/US2008001758

申请日：2008-02-08

Applicant: DENTSPLY INT INC ,  PRIMUS CAROLYN M ,  GUTMANN JAMES L ,  BREUER MIKLOS M ,  JEFFERIES STEVEN R

Inventor： PRIMUS CAROLYN M ,  GUTMANN JAMES L ,  BREUER MIKLOS M ,  JEFFERIES STEVEN R

IPC: A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0032 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/007 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/033 ,  A61K6/06 ,  A61K6/0612 ,  A61K6/0637 ,  A61K6/0675 ,  A61K6/0681 ,  A61K6/0835 ,  A61K6/0035 ,  C08L39/06 ,  C08L29/04 ,  C08L31/04 ,  C08L33/08 ,  C08L33/10 ,  C08L33/14

Abstract: Improved compositions comprising a mixture of particulate materials with water-based liquids containing water-soluble polymers and surfactants are provided. Examples of particulate powders include mixtures of calcium silicate, calcium aluminate, calcium sulfate, and hydroxyapatite. Examples of water-soluble polymers include polyvinyl alcohols, polyvinyl pyrrolidone, partially hydrolyzed polyvinyl acetates, polyacrylic acid, and polymethacrylic acid. Surfactants such as sodium dodecyl sulfate are added to the composition to interact with the polymeric materials. The compositions are particularly suitable for sealing and obturating dental root canals and root apices. The composition provides a stable barrier to bacterial' and fluid leakage in the root canal system of a tooth. In addition, the compositions help promote the growth of new bone and tissue surrounding the root-tip area or dentin tissue that covers an injured or amputated pulp.

Abstract translation: 提供了包含颗粒材料与含有水溶性聚合物和表面活性剂的水性液体的混合物的改进的组合物。 颗粒粉末的实例包括硅酸钙，铝酸钙，硫酸钙和羟基磷灰石的混合物。 水溶性聚合物的实例包括聚乙烯醇，聚乙烯吡咯烷酮，部分水解的聚乙酸乙烯酯，聚丙烯酸和聚甲基丙烯酸。 将表面活性剂如十二烷基硫酸钠加入到组合物中以与聚合物材料相互作用。 该组合物特别适用于密封和填充牙根管和根尖。 该组合物为牙根管系统中的细菌和流体泄漏提供了稳定的屏障。 此外，该组合物有助于促进覆盖受伤或截肢的纸浆的根尖区域或牙本质组织周围的新骨骼和组织的生长。

公开(公告)号：WO2012067577A1

公开(公告)日：2012-05-24

申请号：PCT/SE2011/051378

申请日：2011-11-16

Applicant: DOXA AB ,  HERMANSSON, Leif ,  ALPSTEN, Fredrik

Inventor： HERMANSSON, Leif ,  ALPSTEN, Fredrik

IPC: A61K6/033 ,  A61K6/027 ,  A61K6/06 ,  C04B28/02 ,  C04B28/06 ,  C04B28/18 ,  C04B28/28

CPC classification number: A61L24/02 ,  A61K6/033 ,  A61K6/0637 ,  A61K6/0643 ,  A61L24/001 ,  C04B28/06 ,  C04B28/186 ,  C04B2111/00836 ,  C04B22/126 ,  C04B24/24

Abstract: The present invention relates to chemically bonded ceramic biomaterials, especially a dental material or an implant material. The main binder system forms a chemically bonded ceramic upon hydration thereof, and comprises powdered calcium aluminate and/or calcium silicate, and phase(s) to secure apatite formation at a pH close to neutrality. A second binder system -a cross-linking organic binder system which provides for initial crosslinking of the freshly mixed paste is advantageously added. The invention relates to a powdered composition for preparing the inventive chemically bonded ceramic biomaterial, and a paste from which the biomaterial is formed, as well as a kit comprising the powdered composition and hydration liquid, as well as methods and use of the biomaterial in dental and implant applications with the aim of remineralisation, integration and bone repair.

Abstract translation: 本发明涉及化学结合的陶瓷生物材料，特别是牙科材料或植入材料。 主要的粘合剂体系在其水合时形成化学键合的陶瓷，并且包含粉末状的铝酸钙和/或硅酸钙，以及在接近中性的pH下确保磷灰石形成的相。 有利地加入第二粘合剂体系 - 交联有机粘合剂体系，其提供新混合糊料的初始交联。 本发明涉及用于制备本发明化学结合的陶瓷生物材料的粉末组合物，以及形成生物材料的糊料，以及包含粉末状组合物和水合液体的试剂盒，以及牙科中生物材料的方法和用途 和植入应用，目的是再矿化，整合和骨修复。

公开(公告)号：WO2008100452A3

公开(公告)日：2009-02-12

申请号：PCT/US2008001759

申请日：2008-02-08

Applicant: DENTSPLY INT INC ,  BREUER MIKLOS M ,  PRIMUS CAROLYN M ,  GUTMANN JAMES L

Inventor： PRIMUS CAROLYN M ,  GUTMANN JAMES L

IPC: A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0032 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/007 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/033 ,  A61K6/06 ,  A61K6/0612 ,  A61K6/0637 ,  A61K6/0675 ,  A61K6/0681 ,  A61K6/0835 ,  A61K6/0035 ,  C08L39/06 ,  C08L29/04 ,  C08L31/04 ,  C08L33/08 ,  C08L33/10 ,  C08L33/14

Abstract: Improved compositions for treating dental pulp and root canals comprising a mixture of particulate materials with water-based liquids containing polyvinyl pyrrolidone are provided. Homopolymers and copolymers of polyvinyl pyrrolidone can be used. Optionally, the composition may contain surfactants, humecatants, stabilizers, and other additives. Examples of particulate powders include mixtures of calcium silicate, calcium aluminate, calcium sulfate, and hydroxyapatite. The compositions are particularly suitable for sealing and obturating dental root canals and root apices. The composition provides a stable barrier to bacterial and fluid leakage in the root canal system of a tooth.

Abstract translation: 提供了用于治疗牙髓和根管的改进的组合物，其包括颗粒材料与含有聚乙烯吡咯烷酮的水性液体的混合物。 可以使用聚乙烯吡咯烷酮的均聚物和共聚物。 任选地，所述组合物可以含有表面活性剂，神经迟缓剂，稳定剂和其它添加剂。 颗粒粉末的实例包括硅酸钙，铝酸钙，硫酸钙和羟基磷灰石的混合物。 该组合物特别适用于密封和填充牙根管和根尖。 该组合物为牙根管系统中的细菌和流体泄漏提供了稳定的屏障。

公开(公告)号：WO2008008184A2

公开(公告)日：2008-01-17

申请号：PCT/US2007/014953

申请日：2007-06-27

Applicant: DENTSPLY INTERNATIONAL INC. ,  PRIMUS, Carolyn, M. ,  GUTMANN, James, L.

Inventor： PRIMUS, Carolyn, M. ,  GUTMANN, James, L.

IPC: A61K6/00

CPC classification number: A61K6/0637 ,  A61K6/0088 ,  A61K6/0091 ,  A61K6/0094 ,  A61K6/0612 ,  A61K6/0681 ,  A61K6/0038 ,  C08L7/00 ,  C08L23/20 ,  A61K6/083

Abstract: Improved compositions comprising a mixture of gutta-percha and a hydraulic material containing calcium silicate, calcium aluminate, calcium phosphate, and calcium sulfate compounds are provided. Preferably, the composition includes hydroxylapatite mineral. The composition is particularly suitable for obturating and sealing dental root canals. The composition should provide a stable barrier to bacterial and fluid leakage in the root canal system of a tooth. In addition, the composition should help promote the growth of new bone and tissue surrounding the root tip area.

Abstract translation: 提供了包含gutta-percha和含有硅酸钙，铝酸钙，磷酸钙和硫酸钙化合物的水硬材料的混合物的改进的组合物。 优选地，组合物包括羟基磷灰石矿物。 该组合物特别适用于牙根管灌封和密封。 组合物应为牙根管系统中的细菌和液体渗漏提供稳定的屏障。 此外，组合物应有助于促进根尖周围区域的新骨骼和组织的生长。