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公开(公告)号：WO2021211688A1
公开(公告)日：2021-10-21
申请号：PCT/US2021/027242
申请日：2021-04-14
申请人： DUKE UNIVERSITY
IPC分类号： A61K31/12 , A61K39/215 , A61K47/65 , A61P31/14
摘要： The invention provides SARS-2 spike protein designs and uses thereof. The invention relates, in general, to modified SARS-CoV-2 proteins, nucleic acids encoding these, methods of making recombinant proteins and nucleic acids, compositions comprising these and their use in vaccination regimens, and diagnostic assays.
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2.发明申请VECTORS AND COMPOSITIONS FOR STABLE EXPRESSION OF ANTIGENS IN MYCOBACTERIA 审中-公开用于稳定表达MYCOBACTERIA抗原的载体和组合物
公开(公告)号：WO2015179793A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/032231
申请日：2015-05-22
申请人： DUKE UNIVERSITY , ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： LEE, Sunhee , HAYNES, Barton F. , FROTHINGHAM, Richard , JACOBS, William R. , SCHMITZ, Joern E.
CPC分类号： C12N15/76 , A61K39/12 , A61K2039/522 , A61K2039/523 , C12N2740/16034
摘要： The invention provides mycobacterial plasmids expressing antigens and immunogenic compositions comprising these plasmids, methods for quality control of such compositions, and their use in immunization methods.
摘要翻译： 本发明提供表达抗原的分枝杆菌质粒和包含这些质粒的免疫原性组合物，这些组合物的质量控制方法及其在免疫方法中的用途。
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公开(公告)号：WO2020072162A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/049431
申请日：2019-09-04
申请人： DUKE UNIVERSITY
IPC分类号： A61K38/16 , A61K39/12 , A61K39/21 , A61K39/39 , C12N7/01 , C12N7/04 , C12N15/09 , C12N15/10 , C12N15/33 , C12N15/49
摘要： The invention is directed to modified HIV-l envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-l envelopes and/or these nucleic acids to induce immune responses.
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公开(公告)号：WO2014052620A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/061963
申请日：2013-09-26
申请人： DUKE UNIVERSITY , THE GOVERNMENTOF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY, on behalf of WALTER REED ARMY INSTITUTE OF RESEARCH
发明人： HAYNES, Barton F. , BONSIGNORI, Mattia , LIAO, Hua-xin , FERRARI, Guido , MOODY, Michael A. , KIM, Jerome , MICHAEL, Nelson , POLLARA, Justin
CPC分类号： C07K16/1063 , A61K39/42 , A61K2039/507 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/732 , C07K2317/76
摘要： The present invention relates, in general, to antibody-dependent cellular cytoxicity (ADCC)-mediating antibodies, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention further relates to compositions comprising such antibodies or antibody fragents.
摘要翻译： 本发明一般涉及抗体依赖性细胞细胞毒性（ADCC）介导的抗体，尤其涉及适用于例如降低HIV-1的风险的ADCC介导的抗体（及其片段） 1感染主体。 本发明进一步涉及包含这种抗体或抗体香料的组合物。
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公开(公告)号：WO2018053328A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051877
申请日：2017-09-15
申请人： DUKE UNIVERSITY , MACROGENICS, INC.
发明人： HAYNES, Barton F. , NORDSTROM, Jeffrey Lee , LAM, Chia-Ying Kao , MOODY, M., Anthony , WILLIAMS, LaTonya
CPC分类号： C07K16/2809 , A61K31/167 , A61K38/15 , C07K16/1063 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/626 , C07K2317/64 , C07K2317/76 , C07K2319/00 , C07K2319/70 , A61K2300/00
摘要： The invention is directed to multispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these molecules and methods of use.
摘要翻译： 本发明涉及包含靶向效应细胞的HIV-1包膜靶向臂和臂的多特异性分子，包含这些分子的组合物和使用方法。
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公开(公告)号：WO2018009561A2
公开(公告)日：2018-01-11
申请号：PCT/US2017/040744
申请日：2017-07-05
申请人： DUKE UNIVERSITY
发明人： TOMARAS, Georgia , SEATON, Kelly , SHEN, Shaunna , YATES, Nicole , LIAO, Hua-Xin , HAYNES, Barton F. , VANDERGRIFT, Nathan , ROUNTREE, Wes , BAINBRIDGE, John
摘要： The invention is directed to methods, reagents and kits for detecting incident HIV-1 infection.
摘要翻译： 本发明涉及用于检测事件HIV-1感染的方法，试剂和试剂盒。
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公开(公告)号：WO2015127108A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016663
申请日：2015-02-19
申请人： DUKE UNIVERSITY
发明人： HAYNES, Barton F. , ALAM, S. Munir
CPC分类号： A61K39/12 , C12N2740/16122 , C12N2740/16134
摘要： The invention provides immunogenic compositions which comprise HIV-1 envelope trimers in and a liposome. In other aspects the invention provides method of using compositions HIV-1 envelope trimers to induce immune response in a subject. The invention further provides methods to make compositions which comprise HIV-1 envelope trimers and a liposome.
摘要翻译： 本发明提供了包含HIV-1包膜三聚体的免疫原性组合物和脂质体。 在其它方面，本发明提供了使用组合物HIV-1包膜三聚体在受试者中诱导免疫应答的方法。 本发明还提供制备包含HIV-1包膜三聚体和脂质体的组合物的方法。
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公开(公告)号：WO2023064435A2
公开(公告)日：2023-04-20
申请号：PCT/US2022/046513
申请日：2022-10-13
摘要： Described herein are antibody reagents that bind therapeutic targets such as SARS-COV2 spike protein, as well as methods of using such antibody reagents.
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公开(公告)号：WO2022173940A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/015969
申请日：2022-02-10
申请人： DUKE UNIVERSITY
发明人： SAUNDERS, Kevin , HAYNES, Barton F.
IPC分类号： C07K14/165 , A61K39/215
摘要： The invention is directed to coronavirus based immunogens, including immunogens comprising spike protein and or domains thereof, comprised in multimeric complexes. Provided are also methods of using these immunogens to induce immunogenic responses in a subject.
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公开(公告)号：WO2019070730A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/053994
申请日：2018-10-02
摘要： The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.
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