公开(公告)号：WO2023064435A2

公开(公告)日：2023-04-20

申请号：PCT/US2022/046513

申请日：2022-10-13

Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION ,  DUKE UNIVERSITY

Inventor： ALT, Frederick W. ,  LUO, Sai ,  SAUNDERS, Kevin ,  HAYNES, Barton F.

IPC: C07K16/10 ,  A61K39/42

Abstract: Described herein are antibody reagents that bind therapeutic targets such as SARS-COV2 spike protein, as well as methods of using such antibody reagents.

公开(公告)号：WO2021211688A1

公开(公告)日：2021-10-21

申请号：PCT/US2021/027242

申请日：2021-04-14

Applicant: DUKE UNIVERSITY

Inventor： HENDERSON, Rory ,  SAUNDERS, Kevin ,  HAYNES, Barton F. ,  ACHARYA, Priyamvada

IPC: A61K31/12 ,  A61K39/215 ,  A61K47/65 ,  A61P31/14

Abstract: The invention provides SARS-2 spike protein designs and uses thereof. The invention relates, in general, to modified SARS-CoV-2 proteins, nucleic acids encoding these, methods of making recombinant proteins and nucleic acids, compositions comprising these and their use in vaccination regimens, and diagnostic assays.

公开(公告)号：WO2015179793A1

公开(公告)日：2015-11-26

申请号：PCT/US2015/032231

申请日：2015-05-22

Applicant: DUKE UNIVERSITY ,  ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

Inventor： LEE, Sunhee ,  HAYNES, Barton F. ,  FROTHINGHAM, Richard ,  JACOBS, William R. ,  SCHMITZ, Joern E.

IPC: A61K39/21 ,  A61K39/04 ,  C12N1/21 ,  C12N1/20 ,  A61P37/04 ,  C12N15/09 ,  C12R1/32

CPC classification number: C12N15/76 ,  A61K39/12 ,  A61K2039/522 ,  A61K2039/523 ,  C12N2740/16034

Abstract: The invention provides mycobacterial plasmids expressing antigens and immunogenic compositions comprising these plasmids, methods for quality control of such compositions, and their use in immunization methods.

Abstract translation: 本发明提供表达抗原的分枝杆菌质粒和包含这些质粒的免疫原性组合物，这些组合物的质量控制方法及其在免疫方法中的用途。

公开(公告)号：WO2020072162A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/049431

申请日：2019-09-04

Applicant: DUKE UNIVERSITY

Inventor： SAUNDERS, Kevin ,  HAYNES, Barton F. ,  WIEHE, Kevin J.

IPC: A61K38/16 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  C12N7/01 ,  C12N7/04 ,  C12N15/09 ,  C12N15/10 ,  C12N15/33 ,  C12N15/49

Abstract: The invention is directed to modified HIV-l envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-l envelopes and/or these nucleic acids to induce immune responses.

公开(公告)号：WO2014052620A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/061963

申请日：2013-09-26

Applicant: DUKE UNIVERSITY ,  THE GOVERNMENTOF THE UNITED STATES, as represented by THE SECRETARY OF THE ARMY, on behalf of WALTER REED ARMY INSTITUTE OF RESEARCH

Inventor： HAYNES, Barton F. ,  BONSIGNORI, Mattia ,  LIAO, Hua-xin ,  FERRARI, Guido ,  MOODY, Michael A. ,  KIM, Jerome ,  MICHAEL, Nelson ,  POLLARA, Justin

IPC: C07K16/10 ,  C07K16/46 ,  A61K39/42 ,  A61P31/18

CPC classification number: C07K16/1063 ,  A61K39/42 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/76

Abstract: The present invention relates, in general, to antibody-dependent cellular cytoxicity (ADCC)-mediating antibodies, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention further relates to compositions comprising such antibodies or antibody fragents.

Abstract translation: 本发明一般涉及抗体依赖性细胞细胞毒性（ADCC）介导的抗体，尤其涉及适用于例如降低HIV-1的风险的ADCC介导的抗体（及其片段） 1感染主体。 本发明进一步涉及包含这种抗体或抗体香料的组合物。

公开(公告)号：WO2018053328A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/051877

申请日：2017-09-15

Applicant: DUKE UNIVERSITY ,  MACROGENICS, INC.

Inventor： HAYNES, Barton F. ,  NORDSTROM, Jeffrey Lee ,  LAM, Chia-Ying Kao ,  MOODY, M., Anthony ,  WILLIAMS, LaTonya

IPC: A61K38/00 ,  A61K39/395 ,  A61K39/42 ,  C07K16/10 ,  C07K16/46 ,  C07K19/00

CPC classification number: C07K16/2809 ,  A61K31/167 ,  A61K38/15 ,  C07K16/1063 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/70 ,  A61K2300/00

Abstract: The invention is directed to multispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these molecules and methods of use.

Abstract translation: 本发明涉及包含靶向效应细胞的HIV-1包膜靶向臂和臂的多特异性分子，包含这些分子的组合物和使用方法。

公开(公告)号：WO2018009561A2

公开(公告)日：2018-01-11

申请号：PCT/US2017/040744

申请日：2017-07-05

Applicant: DUKE UNIVERSITY

Inventor： TOMARAS, Georgia ,  SEATON, Kelly ,  SHEN, Shaunna ,  YATES, Nicole ,  LIAO, Hua-Xin ,  HAYNES, Barton F. ,  VANDERGRIFT, Nathan ,  ROUNTREE, Wes ,  BAINBRIDGE, John

IPC: C12Q1/70 ,  G06F19/20

Abstract: The invention is directed to methods, reagents and kits for detecting incident HIV-1 infection.

Abstract translation: 本发明涉及用于检测事件HIV-1感染的方法，试剂和试剂盒。

公开(公告)号：WO2015127108A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/016663

申请日：2015-02-19

Applicant: DUKE UNIVERSITY

Inventor： HAYNES, Barton F. ,  ALAM, S. Munir

IPC: C12N15/48 ,  A61P31/18 ,  C07K14/16

CPC classification number: A61K39/12 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: The invention provides immunogenic compositions which comprise HIV-1 envelope trimers in and a liposome. In other aspects the invention provides method of using compositions HIV-1 envelope trimers to induce immune response in a subject. The invention further provides methods to make compositions which comprise HIV-1 envelope trimers and a liposome.

Abstract translation: 本发明提供了包含HIV-1包膜三聚体的免疫原性组合物和脂质体。 在其它方面，本发明提供了使用组合物HIV-1包膜三聚体在受试者中诱导免疫应答的方法。 本发明还提供制备包含HIV-1包膜三聚体和脂质体的组合物的方法。

公开(公告)号：WO2022173940A1

公开(公告)日：2022-08-18

申请号：PCT/US2022/015969

申请日：2022-02-10

Applicant: DUKE UNIVERSITY

Inventor： SAUNDERS, Kevin ,  HAYNES, Barton F.

IPC: C07K14/165 ,  A61K39/215

Abstract: The invention is directed to coronavirus based immunogens, including immunogens comprising spike protein and or domains thereof, comprised in multimeric complexes. Provided are also methods of using these immunogens to induce immunogenic responses in a subject.

公开(公告)号：WO2019070730A1

公开(公告)日：2019-04-11

申请号：PCT/US2018/053994

申请日：2018-10-02

Applicant: DUKE UNIVERSITY ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： KORBER, Bette ,  GNANAKARAN, Sandrasegaram ,  FERRARI, Guido ,  HAYNES, Barton F.

IPC: A61K38/16 ,  A61K38/17 ,  A61K39/12

Abstract: The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.