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    CARBOXYALKYL CELLULOSE ESTERS FOR SUSTAINED DELIVERY OF PHARMACEUTICALLY ACTIVE SUBSTANCES
    1.
    发明申请
    CARBOXYALKYL CELLULOSE ESTERS FOR SUSTAINED DELIVERY OF PHARMACEUTICALLY ACTIVE SUBSTANCES 审中-公开
    用于持续输送药物活性物质的羧甲基纤维素酯

    公开(公告)号：WO2007056125A3

    公开(公告)日：2007-06-28

    申请号：PCT/US2006042931

    申请日：2006-11-03

    Applicant: EASTMAN CHEM CO

    Inventor： POSEY-DOWTY JESSICA DEE ,  WATTERSON THELMA LEE ,  EDGAR KEVIN JOSEPH ,  KIRK SHANE KIPLEY ,  WELTY MICHAEL LEE ,  YUAN JINGHUA ,  SHELTON MICHAEL CHARLES ,  LINGERFELT LARRY RONNIE JR ,  WILSON ALAN KENT

    IPC: A61K9/10 ,  A61K9/20 ,  A61K9/48

    CPC classification number: A61K9/2054 ,  A61K9/10 ,  A61K9/2013 ,  A61K9/4808 ,  A61K31/717

    Abstract: Disclosed herein are pharmaceutical compositions comprising carboxyalkylcellulose esters for sustained delivery of pharmaceutically active substances. The composition comprises: at least one pharmaceutically active agent, and at least one carboxyalkyl cellulose ester comprising an anhydroglucose repeat unit having the structure (I), wherein: R 1 -R 6 are each independently selected from -OH, -OC(O)(alkyl), and -O(CH 2 ) X C(O)OH, and pharmaceutically acceptable salts thereof, wherein x ranges from 1-3, a degree of substitution per anhydroglucose of - OH ranges from 0.1 to 0.7, a degree of substitution per anhydroglucose of -C(O)(alkyl) ranges from 0.1 to 2.7, and a degree of substitution per anhydroglucose of -O(CH 2 ) X C(O)OH ranges from 0.2 to 0.75, and wherein in pharmaceutically acceptable media, the composition exhibits sustained release of the at least one pharmaceutically active agent. Also disclosed are methods of administering the compositions for sustained delivery, such as delivery following zero order kinetics.

    Abstract translation: 本文公开了包含用于持续递送药物活性物质的羧基烷基纤维素酯的药物组合物。 所述组合物包含：至少一种药学活性剂和至少一种含有具有结构（I）的脱水葡萄糖重复单元的羧基烷基纤维素酯，其中：R 1 -R 6 各自独立地选自-OH，-OC（O）（烷基）和-O（CH 2）2 C（O）OH，和其药学上可接受的盐 其中x为1-3，-OH的每个脱水葡萄糖的取代度为0.1-0.7，-C（O）（烷基）的每个脱水葡萄糖的取代度为0.1- 2.7， -O（CH 2）2 C（O）OH的每个脱水葡萄糖的取代范围为0.2至0.75，并且其中在药学上可接受的介质中，所述组合物显示持续释放 至少一种药物活性剂。 还公开了施用用于持续递送的组合物的方法，例如在零级动力学之后的递送。

    DEVICE TO MEASURE THE SOLIDIFICATION PROPERTIES OF A LIQUID FILM AND METHOD THEREFOR
    3.
    发明申请
    DEVICE TO MEASURE THE SOLIDIFICATION PROPERTIES OF A LIQUID FILM AND METHOD THEREFOR 审中-公开
    用于测量液体膜的凝固特性的装置及其方法

    公开(公告)号：WO2007075354A3

    公开(公告)日：2007-09-20

    申请号：PCT/US2006047782

    申请日：2006-12-14

    Applicant: EASTMAN CHEM CO

    Inventor： SEO KAB SIK ,  POSEY-DOWTY JESSICA DEE

    IPC: G01N11/16 ,  G01N3/00 ,  G01N11/14

    CPC classification number: G01N11/14 ,  G01N2203/0092 ,  G01N2203/0094

    Abstract: The present invention is directed to an apparatus and a method for monitoring the viscoelastic properties, of a liquid film (e.g. coating). The apparatus includes a substrate for supporting a liquid film and a T-bar probe that is partially submerged in the liquid film. The apparatus is designed to be attached to a conventional rheometer equipped with a means for effecting relative movement between the probe and the substrate and means for monitoring the resistance to movement of the probe in contact or partially submerged in the film to obtain a measurement of the solidification properties of the liquid film. This apparatus and method are particularly useful in comparing the effects of film formers, viscosity modifiers, solvents, and minerals on the drying rate of coatings at the early stage of film formation.

    Abstract translation: 本发明涉及用于监测液体膜（例如涂层）的粘弹性性质的设备和方法。 该装置包括用于支撑液膜的基板和部分浸没在液膜中的T形杆探头。 该设备被设计成附接到常规流变仪上，该流变仪配备有用于实现探针和基底之间的相对运动的装置以及用于监测探针接触或部分浸没在膜中的运动的阻力以获得 液膜的固化特性。 该装置和方法在成膜早期比较成膜剂，粘度调节剂，溶剂和矿物质对涂料干燥速率的影响特别有用。

    CYCLODEXTRIN SOLUBILIZERS FOR LIQUID AND SEMI-SOLID FORMULATIONS
    7.
    发明申请
    CYCLODEXTRIN SOLUBILIZERS FOR LIQUID AND SEMI-SOLID FORMULATIONS 审中-公开
    用于液体和半固体配方的环糊精增溶剂

    公开(公告)号：WO2006052921A2

    公开(公告)日：2006-05-18

    申请号：PCT/US2005040355

    申请日：2005-11-08

    Applicant: EASTMAN CHEM CO ,  BUCHANAN CHARLES MICHAEL ,  BUCHANAN NORMA LINDSEY ,  LAMBERT JUANELLE LITTLE ,  POSEY-DOWTY JESSICA DEE

    Inventor： BUCHANAN CHARLES MICHAEL ,  BUCHANAN NORMA LINDSEY ,  LAMBERT JUANELLE LITTLE ,  POSEY-DOWTY JESSICA DEE

    IPC: A61K31/724 ,  A61K9/14

    CPC classification number: A61K9/4866 ,  A61K9/4858 ,  A61K31/724 ,  A61K47/10 ,  A61K47/40

    Abstract: This invention is directed to compositions comprising a water-miscible organic solvent or solvent mixture and one or more cyclodextrin derivatives soluble in the organic water-miscible organic solvent or solvent mixture. In some embodiments, the composition comprises one or more compounds. The invention is further directed to capsules containing the compositions of the present invention and the administration of pharmaceutically active compounds or molecules to subjects. The invention also includes methods of enhancing the solubility of a compound comprising forming a complex or mixture of a compound with a hydroxybutenyl cyclodextrin and a water-miscible solvent.

    Abstract translation: 本发明涉及包含可与水混溶的有机溶剂或溶剂混合物和一种或多种可溶于有机水混溶性有机溶剂或溶剂混合物中的环糊精衍生物的组合物。 在一些实施方案中，组合物包含一种或多种化合物。 本发明还涉及包含本发明组合物的胶囊以及将药物活性化合物或分子施用给受试者。 本发明还包括提高化合物溶解度的方法，包括形成化合物与羟基丁烯基环糊精和水混溶性溶剂的配合物或混合物。

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