公开(公告)号：WO2012067994A2

公开(公告)日：2012-05-24

申请号：PCT/US2011/060556

申请日：2011-11-14

Applicant: ELENZA, INC. ,  BLUM, Ronald David ,  MAZZOCCHI, Rudy

Inventor： BLUM, Ronald David ,  MAZZOCCHI, Rudy

IPC: A61F2/14

CPC classification number: A61F2/1624 ,  A61F2/1613 ,  A61F2/1627 ,  A61F2/1635 ,  A61F2/1648 ,  A61F2210/008 ,  A61F2210/009

Abstract: An implantable ophthalmic device with flexible, fluid-filled membranes provide dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia without moving parts or reducing the amount of transmitted light. Actuating the device causes the fluid-filled membrane to change curvature, which produces a corresponding change in optical power. For instance, squeezing the edge of the membrane causes the center of the membrane to bulge by an amount proportional to the squeezing force. Alternatively, heating or applying a voltage to the membrane may cause the liquid in the membrane to undergo a phase transition accompanied by a corresponding change in volume that causes the membrane to inflate so as to change the optical power of the device.

Abstract translation: 具有柔性流体填充膜的可植入眼科装置提供动态可变的光学功率，以恢复患有老花眼或无晶状体的个体的失去的适应性，而无需移动部件或减少透射光量。 驱动该装置导致流体填充的膜改变曲率，这产生相应的光功率变化。 例如，挤压膜的边缘导致膜的中心膨胀与挤压力成比例的量。 或者，加热或向膜施加电压可能导致膜中的液体经历伴随相应体积变化的相变，导致膜膨胀以改变装置的光功率。

公开(公告)号：WO2012092333A1

公开(公告)日：2012-07-05

申请号：PCT/US2011/067516

申请日：2011-12-28

Applicant: ELENZA, INC. ,  MAZZOCCHI, Rudy ,  BLUM, Ronald David

Inventor： MAZZOCCHI, Rudy ,  BLUM, Ronald David

IPC: A61F2/16

CPC classification number: A61F2/1635 ,  A61F2/1629 ,  A61F2/1648 ,  A61F2002/1681 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2210/0033 ,  A61F2210/0038 ,  A61F2250/0002

Abstract: An implantable ophthalmic device with one or more optical elements coupled to one or more shape-memory members provides dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia. Running current from a power supply through the shape-memory members causes the shape-memory members to heat up. Once the current heats the shape-memory members past a forward phase-transition temperature, the shape-memory members change shape, which, in turn, causes the optical element(s) to move, yielding a corresponding change in effective optical power. Cooling the shape-memory members (e.g., by reducing or stopping the flow of current) below a reverse phase-transition temperature causes the shape-memory members to return to their original shape, which, in turn, restoring the optical element(s) to their original positions and returning the effective optical power to its original level.

Abstract translation: 具有耦合到一个或多个形状记忆部件的一个或多个光学元件的可植入眼科装置提供动态可变的光学功率，以恢复患有老花眼或无晶状体的个体的失去的适应性。 从电源通过形状记忆部件运行电流导致形状记忆部件加热。 一旦电流加热形状记忆元件超过正向相变温度，则形状记忆元件改变形状，这又导致光学元件移动，产生有效光功率的相应变化。 将形状记忆体（例如，通过减少或停止电流的流动）冷却到反相转变温度以下，导致形状记忆元件返回到其原始形状，这反过来恢复光学元件， 到原来的位置，并将有效光功率恢复到原来的水平。

公开(公告)号：WO2012138426A2

公开(公告)日：2012-10-11

申请号：PCT/US2012/025922

申请日：2012-02-21

Applicant: ELENZA, INC. ,  PIXELOPTICS, INC. ,  MAZZOCCHI, Rudy ,  GUPTA, Amitava ,  BLUM, Ronald

Inventor： MAZZOCCHI, Rudy ,  GUPTA, Amitava ,  BLUM, Ronald

IPC: A61F2/14

CPC classification number: A61F2/1648 ,  A61F2/15 ,  A61F2002/1699

Abstract: An implantable ophthalmic device, such as an intraocular lens, includes two or more apertures whose sizes, shapes, and positions are fixed with respect to the device itself. Each of these static apertures replicates an incident image beam as a shifted image beam, where the direction and magnitude of the shift depend on the static aperture's position with respect to the device's optical axis. The device also includes a prismatic element optically coupled to each static aperture. Each prismatic element receives the shifted image beam from its corresponding static aperture and refracts the shifted image beam such that the resulting refracted beams form a single image at the image plane (retina). Together, the static apertures and the prismatic elements increase the device's effective depth of field (e.g., by up to three Diopters).

Abstract translation: 诸如眼内透镜的可植入眼科装置包括其尺寸，形状和位置相对于装置本身固定的两个或更多孔。 这些静态孔径中的每一个将入射的图像束复制为移位的图像束，其中移动的方向和幅度取决于静态孔径相对于装置的光轴的位置。 该装置还包括光学耦合到每个静态孔的棱镜元件。 每个棱镜元件从其对应的静态孔接收移位的图像束，并折射移位的图像束，使得所得的折射光束在图像平面（视网膜）处形成单个图像。 一起，静态孔和棱镜元件增加了设备的有效景深（例如，最多三个屈光度）。

公开(公告)号：WO2011153158A1

公开(公告)日：2011-12-08

申请号：PCT/US2011/038597

申请日：2011-05-31

Applicant: GUPTA, Amitava ,  WOODER, Nicholas ,  BLUM, Ronald, D. ,  MAZZOCCHI, Rudy ,  SCHNELL, Urban ,  ELENZA, INC.

Inventor： GUPTA, Amitava ,  WOODER, Nicholas ,  BLUM, Ronald, D. ,  MAZZOCCHI, Rudy ,  SCHNELL, Urban

IPC: G02C7/08

CPC classification number: A61F2/1616 ,  A61B3/10 ,  A61B5/0031 ,  A61B5/0496 ,  A61B2560/0219 ,  A61F2/1624 ,  A61F2/1627 ,  A61F2/164 ,  A61F2/1648 ,  A61F2250/0002

Abstract: Implantable ophthalmic devices with aspheric lenses and dynamic electro-active elements offer excellent depth of field and image quality while providing high optical throughput. An exemplary implantable ophthalmic device includes an aspheric lens with a negative spherical aberration that varies with radius. The aspheric lens can have peak optical powers at its geometric centers surrounded by a region of varying optical power (with varying slope) that extends radially from its center. When implanted, these aspheric lenses provide an incremental optical power that varies as a function of pupil diameter, which changes with object distance, for viewing far, intermediate, and near objects. The aspheric lens may also bonded or integrally formed with a spherical lens that provides fixed optical power for viewing far objects and/or a dynamic electro-active element that with two or more states (e.g., on and off) for increasing the effective optical power when viewing near objects.

Abstract translation: 具有非球面透镜和动态电活性元件的可植入眼科装置提供优异的景深和图像质量，同时提供高的光学吞吐量。 示例性的可植入眼科装置包括具有随半径变化的负球面像差的非球面透镜。 非球面透镜在其几何中心处可以具有由其从其中心径向延伸的具有变化的光焦度（具有变化的斜率）的区域包围的峰值光焦度。 当植入时，这些非球面透镜提供增加的光学功率，其随瞳孔直径的变化而变化，瞳孔直径随物体距离而改变，用于观察远，中，近物体。 非球面透镜也可以与提供用于观察远物体的固定光焦度的球形透镜结合或整体形成，和/或具有两个或更多个状态（例如，接通和关断）以增加有效光功率的动态电活性元件 查看近物体时。

公开(公告)号：WO2015105881A1

公开(公告)日：2015-07-16

申请号：PCT/US2015/010489

申请日：2015-01-07

Applicant: ELENZA, INC. ,  GUPTA, Amitava ,  MAZZOCCHI, Rudy ,  TRIP, Roel ,  SCHNELL, Urban ,  FEHR, Jean-Noel

Inventor： GUPTA, Amitava ,  MAZZOCCHI, Rudy ,  TRIP, Roel ,  SCHNELL, Urban ,  FEHR, Jean-Noel

IPC: A61F2/16

CPC classification number: A61F2/1624 ,  A61B5/0059 ,  A61F2/1627 ,  A61F2/1659 ,  A61F2002/1696 ,  A61F2250/0001 ,  A61F2250/0002

Abstract: Described herein is an implantable intraocular lens that can automatically adjust its optical power based on the eye's natural response for accommodation of targets at varying distances. The implantable intraocular lens includes a physiological sensor for detecting a physiological response of an eye associated with an ocular accommodation, and an electro-optical element configured to adjust optical power based on the detected physiological response of the eye.

Abstract translation: 这里描述的是可植入的眼内透镜，其可以基于眼睛的自然响应自动调节其光焦度，以适应不同距离的目标。 可植入人工晶状体包括用​​于检测与眼部调节相关联的眼睛的生理反应的生理传感器，以及被配置为基于检测到的眼睛的生理反应来调节光焦度的电光元件。

公开(公告)号：WO2012037019A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/051198

申请日：2011-09-12

Applicant: FEHR, Jean-Noel ,  SCHNELL, Urban ,  DOLL, Walter ,  MICHAELY, Roland ,  ROULET, Jean-Christophe ,  GUPTA, Amitava ,  BLUM, Ronald D. ,  MAZZOCCHI, Rudy

Inventor： FEHR, Jean-Noel ,  SCHNELL, Urban ,  DOLL, Walter ,  MICHAELY, Roland ,  ROULET, Jean-Christophe ,  GUPTA, Amitava ,  BLUM, Ronald D. ,  MAZZOCCHI, Rudy

IPC: A61B3/11

CPC classification number: A61B3/11 ,  A61B3/09 ,  A61B3/112 ,  A61F2/1624 ,  A61F2250/0002 ,  G02C7/083

Abstract: A sensor system includes at least two sensors for distinguishing accommodative stimuli from changes in ambient lights levels and task-induced changes in the pupil diameter. When implanted, the first sensor is disposed completely within the pupil; even when fully constricted, the pupil does not occlude the first sensor, allowing the sensor to make precise measurements of ambient luminous flux levels. The pupil occludes part of the second sensor's active area(s) as the pupil dilates and constricts. As a result, the second sensor measures both ambient luminous flux and pupil diameter. A processor estimates the pupil diameter and determines whether it's changing in response to accommodative stimuli or other factors by comparing to predetermined values. The sensor system sends a signal to an optical component, which in turn can respond by changing optical power to focus for near vision upon detection of accommodative stimuli.

Abstract translation: 传感器系统包括至少两个传感器，用于区分调节刺激与环境光照水平的变化以及瞳孔直径的任务引起的变化。 当植入时，第一传感器完全设置在瞳孔内; 即使完全收缩，瞳孔也不会堵塞第一个传感器，从而允许传感器对环境光通量水平进行精确测量。 当瞳孔扩大和收缩时，瞳孔封闭第二传感器的有效区域的一部分。 结果，第二传感器测量环境光通量和瞳孔直径。 处理器估计瞳孔直径并且通过与预定值进行比较来确定其是否响应于调节刺激或其他因素而改变。 传感器系统将信号发送到光学部件，光学部件又可以通过改变光焦度进行响应，以便在检测到适应刺激时进行近视。

公开(公告)号：WO2017039672A1

公开(公告)日：2017-03-09

申请号：PCT/US2015/048334

申请日：2015-09-03

Applicant: ELENZA, INC.

Inventor： GUPTA, Amitava ,  MAZZOCCHI, Rudy ,  TRIP, Roel ,  PETERSON, Brian ,  CINTRA, George ,  CHEN, Joey ,  HALBERG, Leslie

IPC: A61F2/16 ,  A61F2/56 ,  A61F2/68

CPC classification number: A61F2/1624 ,  A61F2250/0002 ,  G02C11/10 ,  H02J7/025 ,  H02J50/12 ,  H02J50/70

Abstract: An intraocular implant (IOI) includes a lens structure with variable optical power, a sensor that detects an optical accommodation response, a rechargeable power storage device, a recharging interface, a wireless communication interface, and a controller. The controller can receive information from the sensor indicating an optical accommodation response, control the lens structure to vary the variable optical power based on the information received from the sensor, control the recharging interface to recharge the rechargeable power storage device, and further control the recharging interface to receive power for operation of the IOI, and transmit and receive information through the wireless communication interface.

Abstract translation: 眼内植入物（IOI）包括具有可变光功率的透镜结构，检测光学适应响应的传感器，可充电电力存储装置，充电接口，无线通信接口和控制器。 控制器可以从传感器接收指示光学适应响应的信息，根据从传感器接收到的信息控制透镜结构以改变可变光功率，控制再充电接口对可再充电蓄电装置充电，并进一步控制充电 用于接收IOI操作的电力的接口，以及通过无线通信接口发送和接收信息。