公开(公告)号：WO2017083786A1

公开(公告)日：2017-05-18

申请号：PCT/US2016/061715

申请日：2016-11-11

Applicant: ELENZA, INC.

Inventor： GUPTA, Amitava

IPC: G01N27/414 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1473 ,  A61F2/16

CPC classification number: A61B5/1473 ,  A61B5/1459 ,  G01N27/414

Abstract: An implant includes a first calcium sensor portion and a body portion. The first calcium sensor portion includes a calcium-selective binding portion. The body portion includes a controller configured to process a signal received from the calcium-selective binding portion, and a transmitter/receiver.

Abstract translation: 植入物包括第一钙传感器部分和身体部分。 第一钙传感器部分包括钙选择性结合部分。 主体部分包括配置成处理从钙选择性结合部分接收的信号的控制器，以及发射器/接收器。

公开(公告)号：WO2013059195A1

公开(公告)日：2013-04-25

申请号：PCT/US2012/060426

申请日：2012-10-16

Applicant: ELENZA, INC.

Inventor： LINDSTROM, Richard L. ,  DONNENFELD, Eric D. ,  MAZZOCCHI, Rudy A. ,  GUPTA, Amitava

IPC: A61B3/16

CPC classification number: A61B3/16

Abstract: An implantable ophthalmic device includes a processor and an intraocular pressure sensor. This device can be implanted in the eye of a patient suffering from a deficient accommodative response. The sensor detects changes in intraocular pressure caused by accommodation, convergence, ocular muscle movement, and even disease and transmits a signal representing the pressure change(s) to the processor. The processor determines whether an accommodative trigger is present by analyzing the signal for characteristics of intraocular pressure changes due to accommodation. If the processor determines that an accommodative trigger is present, it actuates a dynamic optical element, such as an electro-active shutter or a lens with a variable focal length, so as to change the eye's effective depth of field or focal length. The resulting change in the effective depth of field or focal length enables the patent to view a near object (e.g., an object within about 6 meters of the patient) in response to the accommodative trigger.

Abstract translation: 可植入眼科装置包括处理器和眼内压传感器。 该装置可以植入患有不良调节反应的患者的眼睛中。 传感器检测由调节，收敛，眼肌运动甚至疾病引起的眼内压变化，并将表示压力变化的信号传送到处理器。 处理器通过分析由于调节引起的眼内压变化的特征的信号来确定调节触发是否存在。 如果处理器确定存在调节触发器，则它激活动态光学元件，例如电动快门或具有可变焦距的透镜，以便改变眼睛的有效景深或焦距。 所产生的有效景深或焦距的变化使得专利能够响应于调节性触发来查看近物体（例如，距患者约6米内的物体）。

公开(公告)号：WO2017039672A1

公开(公告)日：2017-03-09

申请号：PCT/US2015/048334

申请日：2015-09-03

Applicant: ELENZA, INC.

Inventor： GUPTA, Amitava ,  MAZZOCCHI, Rudy ,  TRIP, Roel ,  PETERSON, Brian ,  CINTRA, George ,  CHEN, Joey ,  HALBERG, Leslie

IPC: A61F2/16 ,  A61F2/56 ,  A61F2/68

CPC classification number: A61F2/1624 ,  A61F2250/0002 ,  G02C11/10 ,  H02J7/025 ,  H02J50/12 ,  H02J50/70

Abstract: An intraocular implant (IOI) includes a lens structure with variable optical power, a sensor that detects an optical accommodation response, a rechargeable power storage device, a recharging interface, a wireless communication interface, and a controller. The controller can receive information from the sensor indicating an optical accommodation response, control the lens structure to vary the variable optical power based on the information received from the sensor, control the recharging interface to recharge the rechargeable power storage device, and further control the recharging interface to receive power for operation of the IOI, and transmit and receive information through the wireless communication interface.

Abstract translation: 眼内植入物（IOI）包括具有可变光功率的透镜结构，检测光学适应响应的传感器，可充电电力存储装置，充电接口，无线通信接口和控制器。 控制器可以从传感器接收指示光学适应响应的信息，根据从传感器接收到的信息控制透镜结构以改变可变光功率，控制再充电接口对可再充电蓄电装置充电，并进一步控制充电 用于接收IOI操作的电力的接口，以及通过无线通信接口发送和接收信息。

公开(公告)号：WO2014018104A1

公开(公告)日：2014-01-30

申请号：PCT/US2013/030821

申请日：2013-03-13

Applicant: ELENZA, INC.

Inventor： DONNENFELD, Eric, D. ,  MAZZOCCHI, Rudy, A. ,  GUPTA, Amitava

IPC: A61F9/007 ,  A61F9/008

CPC classification number: A61F9/00834 ,  A61F2009/00889

Abstract: Laser posterior capsulotomy is a safe, painless, and effective way to treat posterior capsule opacification (PCO), which is the haze that sometimes develops in the posterior portion of the lens capsule after cataract surgery and IOL implantation. To perform a laser posterior capsulotomy, an ophthalmologist focuses a pulsed laser beam to a spot on the posterior capsule's surface, then scans the beam across the affected tissue. The affected tissue ruptures upon absorbing enough laser light, and the cellular remnants are absorbed by the vitreous humor. Unfortunately, the relatively long pulses used in conventional laser posterior capsulotomy can cause undesired damage to the eye and to the IOL. These risks can be mitigated by using a pulsed laser beam with a pulse duration of about 50-100 femtoseconds, a pulse repetition rate of about 10-50 Hz, and an energy per pulse of about 5-150 μj.

Abstract translation: 激光后囊切开术是治疗后囊膜不透明（PCO）的安全，无痛和有效的方法，其是在白内障手术和IOL植入之后有时在晶状体囊后部发生的阴霾。 为了执行激光后囊膜切开术，眼科医生将脉冲激光束聚焦在后囊的表面上的斑点上，然后扫描穿过受影响组织的束。 受影响的组织在吸收足够的激光后破裂，细胞残余物被玻璃体液吸收。 不幸的是，用于常规激光后囊膜切开术的相对较长的脉冲可能对眼睛和IOL造成不希望的损伤。 这些风险可以通过使用脉冲持续时间约50-100飞秒，脉冲重复率约10-50赫兹，每脉冲能量约5-150微米的脉冲激光束来减轻。

公开(公告)号：WO2012067994A2

公开(公告)日：2012-05-24

申请号：PCT/US2011/060556

申请日：2011-11-14

Applicant: ELENZA, INC. ,  BLUM, Ronald David ,  MAZZOCCHI, Rudy

Inventor： BLUM, Ronald David ,  MAZZOCCHI, Rudy

IPC: A61F2/14

CPC classification number: A61F2/1624 ,  A61F2/1613 ,  A61F2/1627 ,  A61F2/1635 ,  A61F2/1648 ,  A61F2210/008 ,  A61F2210/009

Abstract: An implantable ophthalmic device with flexible, fluid-filled membranes provide dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia without moving parts or reducing the amount of transmitted light. Actuating the device causes the fluid-filled membrane to change curvature, which produces a corresponding change in optical power. For instance, squeezing the edge of the membrane causes the center of the membrane to bulge by an amount proportional to the squeezing force. Alternatively, heating or applying a voltage to the membrane may cause the liquid in the membrane to undergo a phase transition accompanied by a corresponding change in volume that causes the membrane to inflate so as to change the optical power of the device.

Abstract translation: 具有柔性流体填充膜的可植入眼科装置提供动态可变的光学功率，以恢复患有老花眼或无晶状体的个体的失去的适应性，而无需移动部件或减少透射光量。 驱动该装置导致流体填充的膜改变曲率，这产生相应的光功率变化。 例如，挤压膜的边缘导致膜的中心膨胀与挤压力成比例的量。 或者，加热或向膜施加电压可能导致膜中的液体经历伴随相应体积变化的相变，导致膜膨胀以改变装置的光功率。

公开(公告)号：WO2013059656A3

公开(公告)日：2015-06-11

申请号：PCT/US2012061115

申请日：2012-10-19

Applicant: ELENZA INC

Inventor： GUPTA AMITAVA ,  FEHR JEAN-NOEL ,  MICHAELY ROLAND ,  MONTICONE PIER PAOLO ,  MUEHLEMANN THOMAS ,  MORRIS MICHAEL ,  SCHNELL URBAN

IPC: A61F2/16

CPC classification number: A61B3/09 ,  A61B3/16 ,  A61F2/1624 ,  A61F9/0017 ,  A61F9/00781

Abstract: An intraocular implant includes a sensor that, when implanted the eye, detects a physiological change (e.g., change in pupil diameter) associated with an accommodative trigger and emits a signal representing the detected change. A processor coupled to the implant senses and interprets the signal based on one or more thresholds representing the patient's pupillary response to changes in object distance and/or ambient light level. If the processor determines that the signal represents an accommodative trigger, it actuates an electro-active optical element, such as a pixelated liquid-crystal cell, to change the eye's effective optical power and/or depth of field.

Abstract translation: 眼内植入物包括当植入眼睛时检测与调节性触发相关联的生理变化（例如，瞳孔直径的变化）并且发出表示检测到的变化的信号的传感器。 耦合到植入物的处理器基于表示患者对物体距离和/或环境光水平的变化的瞳孔响应的一个或多个阈值来感测和解释信号。 如果处理器确定信号表示调节触发器，则其致动诸如像素化液晶单元之类的电活性光学元件，以改变眼睛的有效光功率和/或景深。

公开(公告)号：WO2013059663A2

公开(公告)日：2013-04-25

申请号：PCT/US2012/061124

申请日：2012-10-19

Applicant: ELENZA, INC.

Inventor： MORRIS, Michael ,  SINNOTT, Loraine ,  FEHR, Jean-Noel ,  MICHAELY, Roland ,  MONTICONE, Pier Paolo ,  MUEHLEMANN, Thomas ,  GUPTA, Amitava

IPC: A61B3/10

CPC classification number: A61B3/09 ,  A61B3/16 ,  A61F2/1624 ,  A61F9/0017 ,  A61F9/00781

Abstract: A patient screening apparatus identifies candidates suitable for receiving accommodative implantable ophthalmic devices, such as dynamic intraocular lenses, based on pupil measurements under different viewing conditions. A pupillometer measures pupil size (pupil diameter or pupil area) and changes in pupil size as a function of ambient light level and/or object distance. For instance, the pupillometer may determine how much the pupil's size changes when the subject transitions from sustained viewing of a distant target to sustained viewing of a near target. These measurements may be used to determine variations in pupil response, including the standard deviation and/or median absolute deviation in pupil size under a given viewing condition, and ratios of pupil sizes and variances in pupil size. The apparatus uses these metrics to estimate whether a patient is likely to benefit from an accommodative implantable ophthalmic device. It can also use them to tune an implantable ophthalmic device.

Abstract translation: 患者筛选装置基于不同观察条件下的瞳孔测量来识别适合于接收调节性可植入眼科装置的候选者，例如动态眼内透镜。 瞳孔尺度测量瞳孔大小（瞳孔直径或瞳孔面积）以及瞳孔大小随着环境光线水平和/或物体距离的变化而变化。 例如，瞳孔尺度可以确定当对象从远距离目标的持续观看转移到近目标的持续观看时，瞳孔的大小变化多少。 这些测量可用于确定瞳孔响应的变化，包括在给定观察条件下的瞳孔尺寸的标准偏差和/或中值绝对偏差，以及瞳孔尺寸和瞳孔尺寸方差的比率。 该装置使用这些度量来估计患者是否可能受益于可调节的可植入眼科装置。 它还可以使用它们调整可植入眼科装置。

公开(公告)号：WO2011153158A1

公开(公告)日：2011-12-08

申请号：PCT/US2011/038597

申请日：2011-05-31

Applicant: GUPTA, Amitava ,  WOODER, Nicholas ,  BLUM, Ronald, D. ,  MAZZOCCHI, Rudy ,  SCHNELL, Urban ,  ELENZA, INC.

Inventor： GUPTA, Amitava ,  WOODER, Nicholas ,  BLUM, Ronald, D. ,  MAZZOCCHI, Rudy ,  SCHNELL, Urban

IPC: G02C7/08

CPC classification number: A61F2/1616 ,  A61B3/10 ,  A61B5/0031 ,  A61B5/0496 ,  A61B2560/0219 ,  A61F2/1624 ,  A61F2/1627 ,  A61F2/164 ,  A61F2/1648 ,  A61F2250/0002

Abstract: Implantable ophthalmic devices with aspheric lenses and dynamic electro-active elements offer excellent depth of field and image quality while providing high optical throughput. An exemplary implantable ophthalmic device includes an aspheric lens with a negative spherical aberration that varies with radius. The aspheric lens can have peak optical powers at its geometric centers surrounded by a region of varying optical power (with varying slope) that extends radially from its center. When implanted, these aspheric lenses provide an incremental optical power that varies as a function of pupil diameter, which changes with object distance, for viewing far, intermediate, and near objects. The aspheric lens may also bonded or integrally formed with a spherical lens that provides fixed optical power for viewing far objects and/or a dynamic electro-active element that with two or more states (e.g., on and off) for increasing the effective optical power when viewing near objects.

Abstract translation: 具有非球面透镜和动态电活性元件的可植入眼科装置提供优异的景深和图像质量，同时提供高的光学吞吐量。 示例性的可植入眼科装置包括具有随半径变化的负球面像差的非球面透镜。 非球面透镜在其几何中心处可以具有由其从其中心径向延伸的具有变化的光焦度（具有变化的斜率）的区域包围的峰值光焦度。 当植入时，这些非球面透镜提供增加的光学功率，其随瞳孔直径的变化而变化，瞳孔直径随物体距离而改变，用于观察远，中，近物体。 非球面透镜也可以与提供用于观察远物体的固定光焦度的球形透镜结合或整体形成，和/或具有两个或更多个状态（例如，接通和关断）以增加有效光功率的动态电活性元件 查看近物体时。

公开(公告)号：WO2013059663A3

公开(公告)日：2015-06-25

申请号：PCT/US2012061124

申请日：2012-10-19

Applicant: ELENZA INC

Inventor： MORRIS MICHAEL ,  SINNOTT LORAINE ,  FEHR JEAN-NOEL ,  MICHAELY ROLAND ,  MONTICONE PIER PAOLO ,  MUEHLEMANN THOMAS ,  GUPTA AMITAVA

IPC: A61B3/10

CPC classification number: A61B3/09 ,  A61B3/16 ,  A61F2/1624 ,  A61F9/0017 ,  A61F9/00781

Abstract: A patient screening apparatus identifies candidates suitable for receiving accommodative implantable ophthalmic devices, such as dynamic intraocular lenses, based on pupil measurements under different viewing conditions. A pupillometer measures pupil size (pupil diameter or pupil area) and changes in pupil size as a function of ambient light level and/or object distance. For instance, the pupillometer may determine how much the pupil's size changes when the subject transitions from sustained viewing of a distant target to sustained viewing of a near target. These measurements may be used to determine variations in pupil response, including the standard deviation and/or median absolute deviation in pupil size under a given viewing condition, and ratios of pupil sizes and variances in pupil size. The apparatus uses these metrics to estimate whether a patient is likely to benefit from an accommodative implantable ophthalmic device. It can also use them to tune an implantable ophthalmic device.

Abstract translation: 患者筛选装置基于不同观察条件下的瞳孔测量来识别适合于接收适应性可植入眼科装置的候选者，例如动态眼内透镜。 瞳孔尺度测量瞳孔大小（瞳孔直径或瞳孔面积）以及瞳孔大小随着环境光线水平和/或物体距离的变化而变化。 例如，瞳孔尺度可以确定当对象从远距离目标的持续观看转移到近目标的持续观看时，瞳孔的大小变化多少。 这些测量可用于确定瞳孔响应的变化，包括在给定观察条件下的瞳孔尺寸的标准偏差和/或中值绝对偏差，以及瞳孔大小和瞳孔大小方差的比率。 该装置使用这些度量来估计患者是否可能受益于调节性可植入眼科装置。 它还可以使用它们来调整可植入眼科装置。

公开(公告)号：WO2013059656A2

公开(公告)日：2013-04-25

申请号：PCT/US2012/061115

申请日：2012-10-19

Applicant: ELENZA, INC. ,  GUPTA, Amitava ,  FEHR, Jean-Noel ,  MICHAELY, Roland ,  MONTICONE, Pier Paolo ,  MUEHLEMANN, Thomas ,  MORRIS, Michael ,  SCHNELL, Urban

Inventor： GUPTA, Amitava ,  FEHR, Jean-Noel ,  MICHAELY, Roland ,  MONTICONE, Pier Paolo ,  MUEHLEMANN, Thomas ,  MORRIS, Michael ,  SCHNELL, Urban

IPC: A61F2/14

CPC classification number: A61B3/09 ,  A61B3/16 ,  A61F2/1624 ,  A61F9/0017 ,  A61F9/00781

Abstract: An intraocular implant includes a sensor that, when implanted the eye, detects a physiological change (e.g., change in pupil diameter) associated with an accommodative trigger and emits a signal representing the detected change. A processor coupled to the implant senses and interprets the signal based on one or more thresholds representing the patient's pupillary response to changes in object distance and/or ambient light level. If the processor determines that the signal represents an accommodative trigger, it actuates an electro-active optical element, such as a pixelated liquid-crystal cell, to change the eye's effective optical power and/or depth of field.

Abstract translation: 眼内植入物包括当植入眼睛时检测与调节性触发相关联的生理变化（例如，瞳孔直径的变化）并且发出表示检测到的变化的信号的传感器。 耦合到植入物的处理器基于表示患者对物体距离和/或环境光水平的变化的瞳孔响应的一个或多个阈值来感测和解释信号。 如果处理器确定信号表示调节触发器，则其致动诸如像素化液晶单元之类的电活性光学元件，以改变眼睛的有效光功率和/或景深。