公开(公告)号：WO2022271677A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034310

申请日：2022-06-21

Applicant: GILEAD SCIENCES, INC.

Inventor： GRAUPE, Michael ,  GUERRERO, Juan A. ,  HOLMBO, Stephen D. ,  JACOBSEN, Jesse M. ,  KOBAYASHI, Tetsuya ,  PATEL, Leena B. ,  WEAVER, Heath A. ,  XU, Jie ,  YEUNG, Suet C.

IPC: C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/08 ,  C07B59/00 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  A61K31/517 ,  C07B59/002

Abstract: The application relates to diacylglycerol kinase modulating quinazolin-2-one derivatives of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：WO2023076983A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078759

申请日：2022-10-27

Applicant: GILEAD SCIENCES, INC.

Inventor： BALAN, Gayatri ,  CHANDRASEKHAR, Jayaraman ,  CHANG, Jonah J. ,  CURRIE, Kevin S. ,  HOLMBO, Stephen D. ,  JACOBSEN, Jesse M. ,  KROPF, Jeffrey E. ,  LEE, Seung H. ,  MOAZAMI, Yasamin ,  PATEL, Leena B. ,  PAUL, Thomas J. ,  PERREAULT, Stephane ,  SALVO, Patrick J. ,  TREIBERG, Jennifer A. ,  WEAVER, Heath A.

IPC: C07D403/08 ,  C07D403/12 ,  C07D413/14 ,  C07D487/04 ,  A61P35/00 ,  A61K31/501 ,  A61K31/502 ,  A61K31/5025

Abstract: Provided herein is a compound of Formula (I) wherein the various substituents are described herein.

公开(公告)号：WO2022271650A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034270

申请日：2022-06-21

Applicant: GILEAD SCIENCES, INC.

Inventor： CODELLI, Julian A. ,  GRAUPE, Michael ,  GUERRERO, Juan A. ,  JACOBSEN, Jesse M. ,  KOBAYASHI, Tetsuya ,  MEDLEY, Jonathan William ,  MOAZAMI, Yasamin ,  PATEL, Leena ,  XU, Jie ,  YEUNG, Suet C.

IPC: C07D471/14 ,  C07D487/04 ,  C07D519/00 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  A61K31/519

Abstract: The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.