公开(公告)号：WO2020092383A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058583

申请日：2019-10-29

Applicant: GILEAD SCIENCES, INC.

Inventor： BLOMGREN, Peter A. ,  CAMPBELL, Taryn ,  CHANDRASEKHAR, Jayaraman ,  CLARK, Christopher T. ,  CODELLI, Julian A. ,  CURRIE, Kevin S. ,  KROPF, Jeffrey E. ,  MOAZAMI, Yasamin ,  NAVA, Nicole ,  PATEL, Leena ,  PERREAULT, Stephane ,  PERRY, Jason K. ,  SEDILLO, Kassandra F. ,  SEEGER, Natalie ,  STEVENS, Kirk L. ,  TREIBERG, Jennifer Anne ,  YEUNG, Suet C. ,  ZHAO, Zhongdong

IPC: C07D405/04 ,  C07C233/87 ,  C07D215/12 ,  C07D215/227 ,  C07D265/36 ,  C07D307/87 ,  C07D311/04 ,  C07D311/58 ,  C07D311/94 ,  C07D319/18 ,  C07D321/10 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  A61K31/4709 ,  A61P29/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：WO2020092375A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058573

申请日：2019-10-29

Applicant: GILEAD SCIENCES, INC.

Inventor： BLOMGREN, Peter A. ,  CAMPBELL, Taryn ,  CHANDRASEKHAR, Jayaraman ,  CLARK, Christopher T. ,  CODELLI, Julian A. ,  CURRIE, Kevin S. ,  KROPF, Jeffrey E. ,  MOAZAMI, Yasamin ,  NAVA, Nicole ,  PATEL, Leena ,  PERREAULT, Stephane ,  PERRY, Jason K. ,  SEDILLO, Kassandra F. ,  SEEGER, Natalie ,  STEVENS, Kirk L. ,  TREIBERG, Jennifer Anne ,  YEUNG, Suet C. ,  ZHAO, Zhongdong

IPC: C07D215/14 ,  C07D215/18 ,  C07D215/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D475/02 ,  C07D491/06 ,  A61K31/47 ,  A61P29/00

Abstract: The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：WO2020092401A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058610

申请日：2019-10-29

Applicant: GILEAD SCIENCES, INC.

Inventor： BLOMGREN, Peter A. ,  CAMPBELL, Taryn ,  CHANDRASEKHAR, Jayaraman ,  CLARK, Christopher T. ,  CODELLI, Julian A. ,  CURRIE, Kevin S. ,  KROPF, Jeffrey E. ,  MOAZAMI, Yasamin ,  NAVA, Nicole ,  PATEL, Leena ,  PERREAULT, Stephane ,  PERRY, Jason K. ,  SEDILLO, Kassandra F. ,  SEEGER, Natalie ,  STEVENS, Kirk L. ,  TREIBERG, Jennifer Anne ,  YEUNG, Suet C. ,  ZHAO, Zhongdong

IPC: A61P29/00 ,  C07C233/73 ,  C07D213/61 ,  C07D215/14 ,  C07D239/46 ,  C07D249/06 ,  C07D311/54 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  A61K31/40

Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：WO2020092394A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/058599

申请日：2019-10-29

Applicant: GILEAD SCIENCES, INC.

Inventor： BLOMGREN, Peter A. ,  CAMPBELL, Taryn ,  CHANDRASEKHAR, Jayaraman ,  CLARK, Christopher T. ,  CODELLI, Julian A. ,  CURRIE, Kevin S. ,  KROPF, Jeffrey E. ,  MOAZAMI, Yasamin ,  NAVA, Nicole ,  PATEL, Leena ,  PERREAULT, Stephane ,  PERRY, Jason K. ,  SEDILLO, Kassandra F. ,  SEEGER, Natalie ,  STEVENS, Kirk L. ,  TREIBERG, Jennifer Anne ,  YEUNG, Suet C. ,  ZHAO, Zhongdong

IPC: C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61P29/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.