公开(公告)号：WO2018130613A1

公开(公告)日：2018-07-19

申请号：PCT/EP2018/050656

申请日：2018-01-11

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MARZANI, Barbara

IPC: A61K36/53 ,  A61K9/00 ,  A61K8/00 ,  A61P17/14

Abstract: The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.

公开(公告)号：WO2016151009A1

公开(公告)日：2016-09-29

申请号：PCT/EP2016/056365

申请日：2016-03-23

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MARZANI, Barbara ,  BARONI, Sergio

IPC: C07D407/04 ,  C07D319/06 ,  A61K31/357 ,  A61P29/00 ,  A61Q19/00

CPC classification number: C07D319/06 ,  A61K8/498 ,  A61Q17/00 ,  C07D407/04

Abstract: The invention relates to compounds having general formula (I): where R = H, CH 2 -OH, CH 2 -O-CO-CH 3 , CH 2 -O-CO-Ph (Ph=phenyl) R' = H, CH 2 -O-CO-CH 3 , CH 2 -O-CO-Ph (Ph = phenyl) Ar = phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care.

Abstract translation: 本发明涉及具有通式（I）的化合物：其中R = H，CH2-OH，CH2-O-CO-CH3，CH2-O-CO-Ph（Ph =苯基）R'= H，CH2-O- CO-CH 3，CH 2 -O-CO-Ph（Ph =苯基）Ar =苯基，3-甲氧基-4-羟基苯基，2-呋喃基。 这些化合物具有抗自由基的抗氧化活性以及抗炎活性，该化合物可用作制备用于皮肤护理的药物皮肤病学或化妆品组合物的活性成分。

公开(公告)号：WO2014020158A1

公开(公告)日：2014-02-06

申请号：PCT/EP2013/066295

申请日：2013-08-02

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MASCOLO, Antonio ,  MARZANI, Barbara ,  BREGAGLIO, Guido

IPC: C08G63/668 ,  A61Q19/00 ,  A61K8/85

CPC classification number: A61K8/86 ,  A61K8/362 ,  A61K8/39 ,  A61K8/466 ,  A61K8/85 ,  A61K2800/54 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/00 ,  A61Q17/005 ,  A61Q19/00 ,  C08G63/12 ,  C08G63/668

Abstract: The present invention relates to polyglycerol-azelaic acid polyesters and cosmetic compositions that incorporate them as active components in combination with a cosmetically acceptable vehicle. In certain aspects the invention also relates to a process for producing esters and polyesters between azelaic acid and glycerol or oligomers thereof containing up to 10 monomer units.

Abstract translation: 本发明涉及将聚甘油 - 壬二酸聚酯和化妆品组合物与化妆品可接受的载体结合使用作为活性组分。 在某些方面，本发明还涉及在壬二酸和甘油之间生产酯和聚酯的方法或其含有至多10个单体单元的低聚物。

公开(公告)号：WO2011161641A2

公开(公告)日：2011-12-29

申请号：PCT/IB2011/052756

申请日：2011-06-23

Applicant: GIULIANI S.P.A. ,  GIULIANI, Giammaria ,  BENEDUSI, Anna ,  PANTINI, Giovanni ,  MASCOLO, Antonio ,  BARONI, Sergio

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  PANTINI, Giovanni ,  MASCOLO, Antonio ,  BARONI, Sergio

IPC: A61K8/19 ,  A61K8/24 ,  A61K8/27 ,  A61K8/365 ,  A61K8/67 ,  A61K8/70 ,  A61K8/73 ,  A61K8/81 ,  A61Q17/04 ,  A61Q19/00

CPC classification number: C08G65/00 ,  A61K8/19 ,  A61K8/24 ,  A61K8/27 ,  A61K8/365 ,  A61K8/676 ,  A61K8/70 ,  A61K8/732 ,  A61K8/8111 ,  A61Q17/04 ,  A61Q19/00

Abstract: The present invention relates, in one aspect, to an adduct of formula O-PF-A, in which O is an oil; PF is a perfluoropolyether phosphate (PFPE phosphate); A is at least one substance selected from: (X) a water-soluble polyhydroxylated substance and (Y) a water-insoluble inorganic substance and to topical applications thereof in particular in the cosmetic and pharmaceutical field.

Abstract translation: 本发明一方面涉及式O-PF-A的加合物，其中O是油; PF是全氟聚醚磷酸盐（PFPE磷酸盐）; A是选自：（X）水溶性多羟基化物质和（Y）水不溶性无机物质中的至少一种物质，特别是在化妆品和药物领域中的局部应用。

公开(公告)号：WO2010125541A1

公开(公告)日：2010-11-04

申请号：PCT/IB2010/051897

申请日：2010-04-30

Applicant: GIULIANI S.P.A. ,  GIULIANI, Giammaria ,  BENEDUSI, Anna

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna

IPC: A61K31/352 ,  A23L1/30 ,  A61K8/49 ,  A61K9/06 ,  A61K9/48

CPC classification number: A61K8/498 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/352 ,  A61K31/353 ,  A61K2300/00 ,  A61K2800/92 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A23V2250/2116 ,  A23V2250/21168 ,  A23V2200/324

Abstract: The object of the invention is a mixture of catechin and quercetin in a molar ratio varying between 3:1 and 6:1, respectively, for the treatment of the immunosuppression induced in the skin by aggressive agents such as airborne pollutants, dehydrating agents, ultraviolet radiation, and thermal and osmotic shocks, and a pharmaceutical, dermatological, nutritional or cosmetic composition containing said mixture as an active ingredient.

Abstract translation: 本发明的目的是分别以3:1和6:1之间的摩尔比变化的儿茶素和槲皮素的混合物，用于治疗皮肤中诱导的免疫抑制剂，例如空气传播的污染物，脱水剂，紫外线 辐射和热和渗透冲击，以及含有所述混合物作为活性成分的药物，皮肤病学，营养或化妆品组合物。

公开(公告)号：WO2015033276A1

公开(公告)日：2015-03-12

申请号：PCT/IB2014/064223

申请日：2014-09-03

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MARZANI, Barbara ,  BARONI, Sergio ,  PICARDO, Mauro

IPC: A61K8/36 ,  A61K8/37 ,  A61K31/202 ,  A61K31/232 ,  A61P17/16 ,  A61P35/00

CPC classification number: A61K31/202 ,  A61K8/362 ,  A61K8/37 ,  A61K9/0014 ,  A61K31/232 ,  A61K31/235 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44 ,  A61K2800/522 ,  A61K2800/591 ,  A61Q17/04 ,  A61K2300/00

Abstract: The invention relates to compounds of general formula (I): CH 3 -(CH=CH) n -R (I) wherein n = 3, 5, 7; R is selected from -CO-OR', -CO-O (-) , or -CH 2 -O-CO-R', R' being selected from H, C 1 -C 22 alkyl or alkenyl.aryl or aralkyl, or sugars; with the proviso that when R is -CH 2 -O-CO-R' and R' alkyl, said alkyl being selected from C 1 to C 11 ; and pharmaceutically acceptable salts thereof, preferably such as sodium, potassium, lysine salts, each compound of general formula (I) being used as such or in admixture with one or more of the other ones, for use in the prevention or treatment of skin cancer resulting from DNA damage produced by UV radiation.

Abstract translation: 本发明涉及通式（I）的化合物：CH 3 - （CH = CH）n -R（I），其中n = 3,5,7; R选自-CO-OR'，-CO-O（ - ）或-CH 2 -O-CO-R'，R'选自H，C 1 -C 22烷基或烯基芳基或芳烷基或糖; 条件是当R是-CH 2 -O-CO-R'和R'烷基时，所述烷基选自C 1至C 11; 和其药学上可接受的盐，优选例如钠，钾，赖氨酸盐，每种通式（I）的化合物原样使用或与一种或多种其它物质混合用于预防或治疗皮肤癌 由UV辐射产生的DNA损伤引起。

公开(公告)号：WO2014174430A1

公开(公告)日：2014-10-30

申请号：PCT/IB2014/060892

申请日：2014-04-22

Applicant: GIULIANI S.P.A.

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  MASCOLO, Antonio ,  LIMITONE, Antonio

IPC: A61K47/36

CPC classification number: A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2853 ,  A61K9/286 ,  A61K31/05 ,  A61K31/07 ,  A61K31/10 ,  A61K31/122 ,  A61K31/198 ,  A61K31/355 ,  A61K31/525 ,  A61K47/36

Abstract: In one aspect, the present invention relates to a system for the modified release of one or more active ingredients, comprising a polymeric matrix based on hyaluronic acid with molecular weight ranging from 100 to 100,000 Daltons and a non-ionic polymer which jellifies in contact with water, in which one or more active ingredients are dispersed, optionally in form of microgranules or microcapsules.

Abstract translation: 一方面，本发明涉及一种用于一种或多种活性成分的改性释放的体系，其包含基于分子量范围为100至100,000道尔顿的透明质酸的聚合物基质和与所述聚合物基质接触的非离子聚合物 水，其中一种或多种活性成分被分散，任选呈微粒或微胶囊形式。

公开(公告)号：WO2012007978A2

公开(公告)日：2012-01-19

申请号：PCT/IT2011/000240

申请日：2011-07-11

Applicant: GIULIANI S.P.A. ,  GIULIANI, Giammaria ,  BENEDUSI, Anna ,  GOBBETTI, Marco ,  DI CAGNO, Raffaella ,  BARONI, Sergio ,  RIZZELLO, Carlo Giuseppe

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  GOBBETTI, Marco ,  DI CAGNO, Raffaella ,  BARONI, Sergio ,  RIZZELLO, Carlo Giuseppe

IPC: C12R1/25 ,  C12R1/225 ,  A23C11/10 ,  A23L1/30 ,  A23L1/29 ,  A61K8/97 ,  A61K36/48 ,  A61K38/16 ,  A61K31/352 ,  A61P1/00 ,  A61P17/14

CPC classification number: A23L1/2008 ,  A23C11/106 ,  A23L11/09 ,  A23L33/105 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/35 ,  A23Y2220/67 ,  A23Y2220/73 ,  A61K8/645 ,  A61K8/97 ,  A61K31/352 ,  A61K31/353 ,  A61K35/747 ,  A61K36/48 ,  A61K38/168 ,  A61Q7/00 ,  A61Q19/00 ,  C12N1/20 ,  C12P21/00 ,  C12R1/225 ,  C12R1/25 ,  A61K2300/00 ,  A23V2200/318 ,  A23V2200/32 ,  A23V2200/324

Abstract: The present invention concerns a mixture comprising isoflavones-aglicones, such as daidzein, genistein and glycitein, in addition to equol and lunasin, said mixture being based on soya fermented using lactic acid bacteria isolated from food matrices and use of said mixture for protection of skin and similar and of human intestinal cells with particular reference to prevention of inflammatory state and protection of barrier functions and hair loss treatment.

Abstract translation: 本发明涉及除了雌马酚和lunasin之外，还含有黄豆苷元，染料木黄酮和黄豆黄素等异黄酮 - 琼脂糖的混合物，所述混合物基于使用从食品基质中分离的乳酸菌发酵的大豆，并使用所述混合物保护皮肤 以及类似的人类肠细胞，特别是关于预防炎症状态和保护屏障功能和脱发治疗。

公开(公告)号：WO2010052329A1

公开(公告)日：2010-05-14

申请号：PCT/EP2009/064881

申请日：2009-11-10

Applicant: GIULIANI S.P.A. ,  GIULIANI, Giammaria ,  BENEDUSI, Anna ,  BARONI, Sergio

Inventor： GIULIANI, Giammaria ,  BENEDUSI, Anna ,  BARONI, Sergio

IPC: A61K31/045 ,  A61K31/11 ,  A61K31/22 ,  A61K31/231 ,  A61K31/232 ,  A61P17/14 ,  A61P17/08 ,  A61P17/16 ,  A61P17/10 ,  A61P35/00 ,  A61P13/08

CPC classification number: A61K31/11 ,  A61K31/045 ,  A61K31/22 ,  A61K31/231 ,  A61K31/232

Abstract: The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5α-reductase. This is a novel use of compounds of general Formula (I): CH 3 (-CH=CH) n -R (I) where n = from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O-CO-R', CO-O (-) , where R' is chosen from among H, and the alky from C 1 to C 22 , each compound of general Formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5α-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.

Abstract translation: 本发明的目的是使用旨在抑制酶5a还原酶活性的化合物。 这是通式（I）的化合物：CH 3（-CH = CH）n R（I）的新颖用途，其中n = 2-7，R选自：CHO，CH 2 OH，CH 2 O-CO-R' ，CO-O（ - ），其中R'选自H，和C1至C22的烷基，通式（I）的每种化合物原样使用或与其它化合物的混合物作为活性成分 设计用于抑制酶5a还原酶的作用的药物或化妆品组合物，以及由其衍生的药物或化妆品组合物。

公开(公告)号：WO2009115455A1

公开(公告)日：2009-09-24

申请号：PCT/EP2009/052961

申请日：2009-03-13

Applicant: GIULIANI S.P.A. ,  MASCOLO, Antonio ,  BENEDUSI, Anna ,  GIULIANI, Giammaria

Inventor： MASCOLO, Antonio ,  BENEDUSI, Anna ,  GIULIANI, Giammaria

IPC: A61K8/60 ,  A61Q19/00

CPC classification number: A61K31/704 ,  A61K8/63 ,  A61K2800/75 ,  A61Q1/14 ,  A61Q19/005 ,  A61Q19/10

Abstract: The present invention relates to the use of an agent to combat and reduce the irritating action of primary surfactants in compositions to be applied to the skin for care or cleansing of the face and body, characterized in that said agent is chosen from one or more salts of glycyrrhizic acid, such as monoammonium glycyrrhizinate (MAG) and dipotassium glycyrrhizinate (DPG).

Abstract translation: 本发明涉及一种药剂用于抵抗和降低主要表面活性剂对要施用于皮肤的组合物的刺激作用，以保护或清洁面部和身体，其特征在于所述药剂选自一种或多种盐 的甘草酸，如甘草酸一铵（MAG）和甘草酸二钾（DPG）。