公开(公告)号：WO2016107849A1

公开(公告)日：2016-07-07

申请号：PCT/EP2015/081302

申请日：2015-12-28

Applicant: IMEC VZW

Inventor： VERCRUYSSE, Dries ,  VAN DORPE, Pol ,  ROTTENBERG, Xavier ,  CLAES, Tom ,  STAHL, Richard

IPC: G02B6/34 ,  G01N15/14 ,  G02B6/12

CPC classification number: G02B6/34 ,  G01N15/1436 ,  G01N15/1484 ,  G02B6/12 ,  G02B2006/12107 ,  G03H1/0443 ,  G03H2001/0447

Abstract: The invention relates to an imaging device (1) comprising a photonic integrated circuit (2). This photonic integrated circuit comprises an integrated waveguide (4) for guiding a light signal (5), a light coupler (8) optically coupled to the integrated waveguide (4) and adapted for directing the light signal (5) out of the plane of the waveguide (4) as a light beam (9), and a microfluidic channel (98) for containing an object (12) immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the device, illumination of the object by the light beam. The integrated circuit further comprises at least one imaging detector (11) positioned for imaging the object (12) illuminated by the light beam (9). The invention also relates to a corresponding method for imaging.

Abstract translation: 本发明涉及一种包括光子集成电路（2）的成像装置（1）。 该光子集成电路包括用于引导光信号（5）的集成波导（4），光耦合到集成波导（4）的光耦合器（8），并且适于将光信号（5）引导出 作为光束（9）的波导（4）和用于容纳浸入流体介质中的物体（12）的微流体通道（98）。 微流体通道被配置为在装置的操作中使得能够通过光束照射物体。 集成电路还包括至少一个成像检测器（11），其定位成对由光束（9）照射的物体（12）成像。 本发明还涉及相应的成像方法。

公开(公告)号：WO2017001534A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065229

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/27

CPC classification number: G01N21/6408 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6413 ,  G01N2021/6439

Abstract: A sensor device (100) for quantifying luminescent targets. The device comprises a light source (111) for exciting the targets, thus generating luminescence signals and a detector (120) for detecting these signals, resulting in a detected signal which comprises a desired signal (310) originating from the targets and a background signal (320). It moreover comprises a bleaching device (135) for bleaching of at least part of the sources generating the background signal (320) and a processor (140) configured to trigger the bleaching device (135) to start bleaching, and to trigger the light source (111) for exciting the remaining luminescent targets which are not bleached, and to trigger the detector (120) for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

Abstract translation: 一种用于量化发光靶的传感器装置（100）。 该装置包括用于激发目标的光源（111），从而产生发光信号，以及用于检测这些信号的检测器（120），产生检测信号，该检测信号包括源自目标的期望信号（310）和背景信号 （320）。 它还包括漂白装置（135），用于漂白产生背景信号的源的至少一部分（320）和配置成触发漂白装置（135）开始漂白的处理器（140），并触发光源 （111），用于激发未漂白的剩余发光靶，并且触发检测器（120）以检测剩余的发光靶的发光信号，以产生代表发光靶的量化的测量信号。

公开(公告)号：WO2017001536A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065232

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/17 ,  G01N21/64

CPC classification number: G01N21/1717 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/1731

Abstract: A sensor device (100) for quantifying luminescent targets comprises a light source (111), a detector (120), a modulator (130), and a processor (140). The light source (111) is adapted for exciting the luminescent target. The detector (120) is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator (130) is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor (140) is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

Abstract translation: 用于量化发光靶的传感器装置（100）包括光源（111），检测器（120），调制器​​（130）和处理器（140）。 光源（111）适于激发发光靶。 检测器（120）适于检测发光目标的发光，从而产生包含源自发光目标的期望信号和背景信号的测量信号。 调制器（130）适于调制产生与背景信号的调制不同的期望信号的调制的物理参数。 处理器（140）被配置为将物理参数的调制与期望信号的调制和/或背景信号的调制相关联。

公开(公告)号：WO2020178004A1

公开(公告)日：2020-09-10

申请号：PCT/EP2020/053866

申请日：2020-02-14

Applicant: IMEC VZW

Inventor： JAMES SHIRLEY, Finub ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/51

Abstract: The present invention provides an apparatus for detecting photoluminescent light emitted from a sample, said apparatus (200; 300) comprising at least one light source (210; 310, 318), which is configured to emit light of a first and a second wavelength towards a sample comprising photoluminescent particles, wherein said first wavelength is an excitation wavelength for inducing photoluminescent light from said photoluminescent particles, and wherein said second wavelength is longer than said first wavelength and for gathering background noise information from said sample. The apparatus further comprises a photo-detector (206) for detecting light incident on the photo-detector (206); and an interference filter (204; 304) arranged on the photo-detector (206), wherein the interference filter (204; 304) is configured to selectively collect and transmit light towards the photo-detector (206) based on an angle of incidence of the light towards the interference filter (204; 304), wherein the interference filter (204; 304) is configured to selectively transmit supercritical angle light from the sample towards the photo-detector (206) and suppress undercritical angle light from the sample.

公开(公告)号：WO2019120642A1

公开(公告)日：2019-06-27

申请号：PCT/EP2018/070007

申请日：2018-07-24

Applicant: IMEC VZW

Inventor： CHEN, Chang ,  MARTENS, Koen ,  VAN DORPE, Pol ,  SEVERI, Simone

IPC: G01N33/487 ,  G01N27/414

Abstract: In a first aspect, the present invention relates to a nanopore field-effect transistor sensor (100), comprising: i) a source region (310) and a drain region (320), defining a source-drain axis; ii) a channel region (330) between the source region (310) and the drain region (320); iii) a nanopore (400), defined as an opening in the channel region (330) which completely crosses through the channel region (330), oriented at an angle to the source-drain axis, having a first orifice (410) and a second orifice (420), and being adapted for creating a non-linear potential profile between the first (410) and second (420) orifice.

公开(公告)号：WO2015177373A1

公开(公告)日：2015-11-26

申请号：PCT/EP2015/061479

申请日：2015-05-22

Applicant: IMEC VZW

Inventor： VAN DORPE, Pol ,  LAGAE, Liesbet ,  PEUMANS, Peter ,  STASSEN, Andim ,  HELIN, Philippe ,  DU BOIS, Bert ,  SEVERI, Simone

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7703 ,  G01N2201/0873

Abstract: The invention provides an integrated semiconductor device (100) for detecting fluorescent tags, comprising a first layer (101) comprising a detector element (107), a second layer (102) located on top of the first layer (101) and comprising a rejection filter, a third layer (103) located on top of the second layer (102) and being fabricated from a dielectric material, a fourth layer (104) located on top of the third layer (103) and comprising an optical waveguide, and furthermore a fifth layer located on top of the fourth layer comprising a microfluidic channel (106). The optical waveguide is configured and positioned such that the micro-fluidic channel (106) is illuminated with an evanescent tail of excitation light guided by the optical waveguide. The rejection filter is positioned such that fluorescence from activated fluorescent tags present on top of the fourth layer (104) is filtered before falling onto the detector element (107). The rejection filter is configured to reject the wavelength range of the excitation light and configured to transmit the wavelength range of fluorescence from the activated fluorescent tags towards the detector element (107).

Abstract translation: 本发明提供了一种用于检测荧光标签的集成半导体器件（100），包括：第一层（101），包括检测器元件（107），位于第一层（101）顶部的第二层（102） 过滤器，位于第二层（102）的顶部并由电介质材料制成的第三层（103），位于第三层（103）的顶部上并包括光波导的第四层（104），此外 位于第四层顶部的第五层包括微流体通道（106）。 光波导被配置和定位成使得微流体通道（106）被由光波导引导的激发光的渐逝尾部照亮。 排斥滤光器被定位成使得存在于第四层（104）的顶部上的来自活化荧光标签的荧光在落到检测器元件（107）之前被过滤。 拒绝滤波器被配置为拒绝激发光的波长范围并且被配置为将荧光的波长范围从激活的荧光标签朝向检测器元件（107）传输。

公开(公告)号：WO2015110614A1

公开(公告)日：2015-07-30

申请号：PCT/EP2015/051421

申请日：2015-01-23

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/77

CPC classification number: G01N21/7746 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/6439 ,  G01N2021/7716 ,  G01N2021/7786 ,  G02B6/00 ,  G02B6/1223 ,  G02B6/1228 ,  G02B6/125 ,  G02B6/4214 ,  G02B2006/12147

Abstract: An integrated waveguide structure (100) comprises a substrate (104) and a waveguide layer on top thereof. The waveguide layer comprises an excitation waveguide (101) for transmitting excitation radiation to activate a fluorescent particle, an emission waveguide (102) configured for transmitting radiation emitted by the fluorescent particle and a particle radiation coupler (106) being a resonator element arranged for coupling radiation emitted by the fluorescent particle into the emission waveguide (102). The structure also comprises at least one sensing site (103) configured with respect to the at least one excitation waveguide (101) and emission waveguide (102) such that a fluorescent particle at the sensing site is activated by the excitation radiation transmitted via the at least one excitation waveguide (101) and radiation emitted by the fluorescent particle is coupled into the emission waveguide (102) by the particle radiation coupler (106).

Abstract translation: 集成波导结构（100）包括在其顶部上的衬底（104）和波导层。 波导层包括用于传输激发辐射以激活荧光颗粒的激发波导（101），被配置为传输由荧光颗粒发射的辐射的发射波导（102）和作为耦合的谐振元件的粒子辐射耦合器（106） 由荧光颗粒发射到发射波导（102）中的辐射。 该结构还包括相对于至少一个激励波导（101）和发射波导（102）配置的至少一个感测位置（103），使得感测位置处的荧光颗粒通过经由at 至少一个激发波导（101）和由荧光颗粒发射的辐射通过粒子辐射耦合器（106）耦合到发射波导（102）中。

公开(公告)号：WO2015082564A1

公开(公告)日：2015-06-11

申请号：PCT/EP2014/076457

申请日：2014-12-03

Applicant: IMEC VZW

Inventor： VAN DORPE, Pol ,  PEUMANS, Peter

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/443 ,  A61B5/681 ,  A61B2562/0233 ,  G01B9/02091 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/35 ,  G01N21/65 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/12

Abstract: An integrated circuit (100) is presented, comprising: a first optical unit comprising: a RAMAN spectrometer (102); an OCT spectrometer (103); an interferometer (104) optically coupled to the OCT spectrometer; and a light coupler (105), positioned to couple scattered and reflected light from illuminated tissue into the RAMAN and OCT spectrometer (102, 103); and an imaging region (106) optically coupled to the RAMAN and OCT spectrometer (102, 103). Further, a system and method to measure the concentration of an analyte in tissue is presented.

Abstract translation: 提供了一种集成电路（100），包括：第一光学单元，包括：拉曼光谱仪（102）; OCT光谱仪（103）; 光学耦合到所述OCT光谱仪的干涉仪（104）; 以及光耦合器（105），定位成将来自照射组织的散射光和反射光耦合到RAMAN和OCT光谱仪（102,103）中; 以及光学耦合到RAMAN和OCT光谱仪（102,103）的成像区域（106）。 此外，提出了测量组织中分析物浓度的系统和方法。

公开(公告)号：WO2019057707A1

公开(公告)日：2019-03-28

申请号：PCT/EP2018/075193

申请日：2018-09-18

Applicant: IMEC VZW ,  KATHOLIEKE UNIVERSITEIT LEUVEN

Inventor： JAMES SHIRLEY, Finub ,  VAN DORPE, Pol

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/6454 ,  G01N2021/6465 ,  G01N2021/6471

Abstract: An apparatus for detecting fluorescent light emitted from a sample comprises: a light source (210; 310, 318), which is configured to emit excitation light of an excitation wavelength towards a sample comprising fluorophores such that fluorescent light is induced; a photo-detector (206) for detecting light incident on the photo-detector (206); and an interference filter (204; 304) arranged on the photo-detector (206), wherein the interference filter (204; 304) is configured to selectively collect and transmit light towards the photo-detector (206) based on an angle of incidence of the light towards the interference filter (204; 304), wherein the interference filter (204; 304) is configured to selectively transmit supercritical angle fluorescence from the sample towards the photo-detector (206) and suppress undercritical angle fluorescence from the sample.

公开(公告)号：WO2017001526A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065219

申请日：2016-06-29

Applicant: IMEC VZW

Inventor： PEUMANS, Peter ,  LAGAE, Liesbet ,  VAN ROY, Willem ,  STAKENBORG, Tim ,  VAN DORPE, Pol

IPC: G01N21/64 ,  G01N21/17

CPC classification number: G01N21/6452 ,  G01N21/1717 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/1731 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439

Abstract: A sensor device (100) for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector (120) for obtaining an at least one dimensional pattern of measured signals, wherein the detector (120) is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor (140) configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.

Abstract translation: 一种用于量化以至少一维图案配置的发光目标的传感器装置（100）。 传感器装置包括用于获得测量信号的至少一维图案的检测器（120），其中检测器（120）适于检测发光靶的发光，产生测量图案。 传感器装置还包括被配置成将所测量的图案与至少一个参考图案相关联的处理器（140），以产生代表发光目标的量化的测量信号。 至少一个参考图案是记录图案或预期图案。 记录图案是在获得测量图案之前由检测器获得的图案。