公开(公告)号：WO2006063205A3

公开(公告)日：2007-02-22

申请号：PCT/US2005044562

申请日：2005-12-08

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  YANG HAITAO ,  WANG GANG ,  MELMAN JONATHAN

Inventor： XIANG XIAO-DONG ,  YANG HAITAO ,  WANG GANG ,  MELMAN JONATHAN

IPC: G01V3/00 ,  G05F1/00

CPC classification number: G01N33/542 ,  G01N24/087 ,  G01N24/088 ,  G01N2500/00 ,  G01R33/323 ,  G01R33/34 ,  G01R33/34053 ,  G01R33/3456 ,  G01R33/44 ,  G01R33/46 ,  G01R33/48 ,  G01R33/60 ,  G06F19/16

Abstract: High throughput screening of catalyst libraries may be performed using spin resonance techniques, and an evanescent wave probe developed by the present inventors. The probe may operate using either nuclear magnetic resonance or electron spin resonance techniques. In one configuration, a scanning evanescent wave spin resonance probe is used in conjunction with a library of catalysts or other materials, and localized detection of spin resonance is carried out at each library address. In another configuration, the evanescent wave probe is used in a micro-reactor array assay.

Abstract translation: 可以使用自旋共振技术和由本发明人开发的ev逝波探针来进行催化剂文库的高通量筛选。 探针可以使用核磁共振或电子自旋共振技术进行操作。 在一种配置中，扫描ev逝波自旋共振探针与催化剂或其他材料的文库结合使用，并且在每个文库地址进行自旋共振的局部检测。 在另一种配置中，ev逝波探针用于微反应器阵列测定。

公开(公告)号：WO2007061843A2

公开(公告)日：2007-05-31

申请号：PCT/US2006044672

申请日：2006-11-17

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  WANG GANG ,  YANG HAITAO ,  MELMAN JONATHAN ,  DIONNE GERALD FRANCIS

Inventor： XIANG XIAO-DONG ,  WANG GANG ,  YANG HAITAO ,  MELMAN JONATHAN ,  DIONNE GERALD FRANCIS

IPC: A61F2/00

CPC classification number: A61N1/406 ,  A61K41/0052 ,  A61K49/1818

Abstract: The present embodiments are directed to cancer therapy; specifically a technique called "nanoparticle ferromagnetic resonance heating," where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cancer cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (?-Fe 2 O 3 ) based compounds, and yttrium iron garnet (Y 3 Fe 5 O 12 ) based compounds.

Abstract translation: 本实施例涉及癌症治疗; 具体地，称为“纳米颗粒铁磁共振加热”的技术，其中除了RF热疗处理之外的铁磁共振加热被用于引起癌细胞凋亡和坏死。 用于进行肿瘤的铁磁共振加热处理的装置包括肿瘤内部所含的超顺磁性颗粒的体积浓度，其浓度范围为约0.1％至约1％; 磁场源，被配置为向所述肿瘤的区域递送梯度DC磁场; 以及能量源，其被配置为以大约100至200MHz的频率向所述肿瘤输送RF场。 2.根据权利要求1所述的装置，其中所述超顺磁性粒子选自由以下物质组成的组：由磁赤铁矿（α-Fe 2 O 3 O 3）基化合物和钇铁石榴石（Y 3 5 12 12）基的化合物。

公开(公告)号：WO2006017249A2

公开(公告)日：2006-02-16

申请号：PCT/US2005024597

申请日：2005-07-12

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  YANG HAITAO ,  WANG GANG

Inventor： XIANG XIAO-DONG ,  YANG HAITAO ,  WANG GANG

IPC: C12Q1/68

CPC classification number: G01Q10/065 ,  G01Q60/22

Abstract: Novel systems of an evanescent microwave probe (EWP) are disclosed, which enable measurements of physical properties of a sample with enhanced sensitivity and resolution, simultaneously. In one embodiment, new shielding features are added to the probe (which may be of either a sharpened tip or loop configuration) to reduce the effects of residual far field radiation, while maintaining the probe section that extends beyond the shielding aperture of the resonator. To further increase the sensitivity of the instrument, an automatic gain-controlled active feedback loop system may be added to the probe resonator to form a self-oscillator. This new active circuit feature significantly increases the effective Q of the resonator probe, enhancing the sensitivity of both the frequency and Q measurement.

Abstract translation: 公开了一种ev逝微波探测器（EWP）的新型系统，可同时测量具有增强灵敏度和分辨率的样品的物理性能。 在一个实施例中，将新的屏蔽特征添加到探头（其可以是尖锐的尖端或环形配置）以减少残余远场辐射的影响，同时保持探头部分延伸超出谐振器的屏蔽孔径。 为了进一步增加仪器的灵敏度，可以将自动增益控制的主动反馈回路系统添加到探头谐振器中以形成自振荡器。 这种新的有源电路特征显着增加了谐振器探头的有效Q，提高了频率和Q测量的灵敏度。

公开(公告)号：WO2007061843A8

公开(公告)日：2007-08-16

申请号：PCT/US2006044672

申请日：2006-11-17

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  WANG GANG ,  YANG HAITAO ,  MELMAN JONATHAN ,  DIONNE GERALD FRANCIS

Inventor： XIANG XIAO-DONG ,  WANG GANG ,  YANG HAITAO ,  MELMAN JONATHAN ,  DIONNE GERALD FRANCIS

IPC: A61F2/00

CPC classification number: A61N1/406 ,  A61K41/0052 ,  A61K49/1818

Abstract: The present embodiments are directed to cancer therapy; specifically a technique called "nanoparticle ferromagnetic resonance heating," where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cancer cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (?-Fe 2 O 3 ) based compounds, and yttrium iron garnet (Y 3 Fe 5 O 12 ) based compounds.

公开(公告)号：WO2007127103A3

公开(公告)日：2008-12-24

申请号：PCT/US2007009361

申请日：2007-04-17

Applicant: INTEMATIX CORP ,  SHAN WEI ,  WANG GANG ,  XIANG XIAO DONG

Inventor： SHAN WEI ,  WANG GANG ,  XIANG XIAO DONG

IPC: H02N6/00 ,  H01L31/042

CPC classification number: G02B19/0076 ,  G02B5/045 ,  G02B19/0028 ,  G02B19/0042 ,  H01L31/042 ,  H01L31/0543 ,  H01L31/0547 ,  H01L31/0549 ,  Y02E10/52

Abstract: The present inventions are solar cell assemblies comprising a combination of efficiency enhancing features, such as, a photovoltaic cell array including two or more members having different band gaps, dispersive optics capable of directing wavelengths of incoming light to the most efficient cells for those wavelengths, light concentrators to focus incoming light onto the appropriate cells, and electrically conductive light concentrators that can act as contacts and transmission paths for current generated in the assembly.

Abstract translation: 本发明是包括效率增强特征的组合的太阳能电池组件，例如包括具有不同带隙的两个或多个构件的光伏电池阵列，能够将入射光的波长指向用于那些波长的最有效单元的分散光学器件， 聚光器将入射光聚焦到适当的电池上，以及导电光聚集器，其可以充当在组件中产生的电流的接触和传输路径。

公开(公告)号：WO2007087343A3

公开(公告)日：2008-09-04

申请号：PCT/US2007001874

申请日：2007-01-24

Applicant: INTEMATIX CORP ,  SHAN WEI ,  WANG GANG ,  XIANG XIAO DONG

Inventor： SHAN WEI ,  WANG GANG ,  XIANG XIAO DONG

IPC: F24S50/20 ,  H01L25/00 ,  H01L31/042

CPC classification number: H01L31/052 ,  F24J2/08 ,  F24J2/1047 ,  F24J2/38 ,  F24J2/4612 ,  F24J2/4618 ,  F24J2/5431 ,  F24J2002/0084 ,  F24J2002/1023 ,  F24J2002/108 ,  F24J2002/5468 ,  H01L31/0543 ,  H01L31/0547 ,  H01L35/30 ,  H02S20/32 ,  H02S40/44 ,  Y02E10/47 ,  Y02E10/52 ,  Y02E10/60

Abstract: Disclosed are fixed solar-electric modules having arrays of solar concentrator assemblies capable of separately tracking movements through one or two degrees of rotational freedom to follow the movement of the sun daily and/or seasonally. The concentrators can include optical elements to direct and concentrate light onto photovoltaic and/or thermoelectric receivers for generation of electric current.

Abstract translation: 公开了具有太阳能集中器组件的阵列的固定太阳能电模块，其能够单独地跟踪通过一个或两个旋转自由度的运动，以跟随太阳每天和/或季节性的运动。 集中器可以包括光学元件以将光引导并聚集到光伏和/或热电接收器上以产生电流。

公开(公告)号：WO2008057138A3

公开(公告)日：2008-11-06

申请号：PCT/US2007008320

申请日：2007-04-04

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  MELMAN JONATHAN ,  WANG GANG

Inventor： XIANG XIAO-DONG ,  MELMAN JONATHAN ,  WANG GANG

IPC: C09K11/54 ,  C09K11/77

CPC classification number: C40B40/00 ,  G01N33/60

Abstract: The combinatorial approach to materials synthesis can create vast libraries of materials. Some luminescent materials can be activated by the application of electrical current. Additionally, these materials can be activated by the application of an electron gun or some other electron source, such as a /3-emitter. In its simplest form, a library of materials can be screened for luminescence by placing the library in a position to collect beta particles emitted from radioactive /3-emitters.

Abstract translation: 材料合成的组合方法可以创建大量的材料库。 一些发光材料可以通过施加电流来激活。 此外，这些材料可以通过应用电子枪或其他电子源（如三分之一发射器）来激活。 以其最简单的形式，可以通过将文库放置在收集放射性/ 3-发射体发射的β粒子的位置来筛选材料库中的发光。

公开(公告)号：WO2007126725A3

公开(公告)日：2008-04-24

申请号：PCT/US2007007358

申请日：2007-03-23

Applicant: INTEMATIX CORP ,  XIANG XIAO-DONG ,  WANG GANG ,  SHAN WEI ,  MELMAN JONATHAN

Inventor： XIANG XIAO-DONG ,  WANG GANG ,  SHAN WEI ,  MELMAN JONATHAN

IPC: G01N33/00

CPC classification number: G01N21/1717

Abstract: Disclosed are methods to synthesize new functional materials in an effective and efficient way. These methods include physical vapor deposition and laser-assisted epitaxial growth capable of synthesizing materials comprising a plurality of precursors with similar or dissimilar chemical and/or physical properties. The designated materials are formed during the combinatorial synthesis without the neccessity of post-deposition furnace heating to thermally activate simultaneous reaction and diffusion of precursor multilayers. Modulated photoreflectance spectroscopy may be used to screen regions of the library to assess deposition conditions.

Abstract translation: 公开了以有效和高效的方式合成新功能材料的方法。 这些方法包括物理气相沉积和激光辅助外延生长，其能够合成包含具有相似或不同化学和/或物理性质的多种前体的材料。 指定的材料在组合合成期间形成，而不需要后沉积炉加热，以热激活前体多层的同时反应和扩散。 可以使用调制光反射光谱来筛选文库的区域以评估沉积条件。

公开(公告)号：WO2009114390A3

公开(公告)日：2009-12-30

申请号：PCT/US2009036214

申请日：2009-03-05

Applicant: INTEMATIX CORP ,  LI YI-QUN ,  WANG GANG ,  CHEN LI-DE

Inventor： LI YI-QUN ,  WANG GANG ,  CHEN LI-DE

IPC: H01J1/62

CPC classification number: H01L33/504 ,  C09K11/0883 ,  C09K11/7733 ,  C09K11/7734 ,  C09K11/7739 ,  C09K11/7774 ,  C09K11/7792 ,  F21K9/00 ,  F21V9/16 ,  H01L25/0753 ,  H01L33/50 ,  H01L2924/0002 ,  Y02B20/181 ,  H01L2924/00

Abstract: Embodiments of the invention are directed toward white light illumination systems (so called 'white LEDs') that comprise a multi-chip excitation source and a phosphor package. In a two-chip source, the two LEDs may be UV-emitting and blue emitting, or blue-emitting and green-emitting. The phosphor package is configured to emit photoluminescence in wavelengths ranging from about 440 nm to about 700 nm upon co-excitation from the first and second radiation sources. The photoluminescence emitted by the phosphors is at least 40 percent of the total power in the white light illumination, and the portion of the total power in the white light illumination contributed by the first and second radiation sources (LEDs) is less than about 60 percent. This ratio can vary in alternative embodiments, and includes 50/50, 60/40, 70/30, and 80/20, respectively. The white light illumination emitted by the system has in one embodiment a color rendering index (CRI) greater than about 90.

Abstract translation: 本发明的实施例针对包括多芯片激励源和磷光体封装的白光照明系统（所谓的“白色LED”）。 在双芯片源中，两个LED可以是紫外发射和蓝色发射，或蓝色发射和绿色发射。 磷光体封装被配置为在从第一和第二辐射源共同激发时发射范围从约440nm到约700nm的波长的光致发光。 由荧光体发射的光致发光是白光照明中总功率的至少40％，并且由第一和第二辐射源（LED）贡献的白光照明中的总功率部分小于约60％ 。 该比率可以在替代实施例中变化，并且分别包括50 / 50,60 / 40,70 / 30和80/20。 在一个实施例中，由系统发射的白光照明具有大于约90的显色指数（CRI）。

公开(公告)号：WO2008082673A3

公开(公告)日：2009-01-22

申请号：PCT/US2007026526

申请日：2007-12-28

Applicant: ABBOTT LAB ,  SEMIZAROV DIMITRI ,  MCKEEGAN EVELYN M ,  LESNIEWSKI RICK R ,  TSE CHRISTIN ,  WANG GANG

Inventor： SEMIZAROV DIMITRI ,  MCKEEGAN EVELYN M ,  LESNIEWSKI RICK R ,  TSE CHRISTIN ,  WANG GANG

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/106

Abstract: A method for classifying cancer patients as eligible to receive cancer therapy comprising determination of the presence or absence in a patient tissue sample of chromosomal copy number gain at chromosomal locus 18q21-q22. The classification of cancer patients based upon the presence or absence of 18q21-q22 gain allows selection of patients to receive chemotherapy, such as therapy with a Bcl-2 family inhibitor, and for monitoring patient response to therapy.

Abstract translation: 用于将癌症患者分类为有资格接受癌症治疗的方法，包括确定患者组织样品中染色体基因座18q21-q22染色体拷贝数增加的存在与否。 基于存在或不存在18q21-q22增益的癌症患者的分类允许选择患者接受化学疗法，例如用Bcl-2家族抑制剂治疗，并且监测患者对治疗的反应。