公开(公告)号：WO2018172984A1

公开(公告)日：2018-09-27

申请号：PCT/IB2018/051973

申请日：2018-03-23

Applicant: JACOBIO PHARMACEUTICALS CO., LTD. ,  JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.

Inventor： MA, Cunbo ,  GAO, Panliang ,  HU, Shaojing ,  XU, Zilong ,  HAN, Huifeng ,  WU, Xinping ,  KANG, Di ,  LONG, Wei

IPC: C07D241/18 ,  C07D241/20 ,  C07D401/14 ,  C07D401/04 ,  C07D491/107 ,  C07D498/10 ,  C07D471/10 ,  A61K31/497 ,  A61P35/00 ,  A61P35/02

Abstract: This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

公开(公告)号：WO2018019252A1

公开(公告)日：2018-02-01

申请号：PCT/CN2017/094474

申请日：2017-07-26

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： ZHOU, Wenlai ,  LI, Runze ,  GAO, Panliang ,  WU, Xinping ,  BAI, Jinlong ,  YANG, Guiqun ,  WANG, Yanping ,  KANG, Di

IPC: C07D401/12 ,  C07D413/12 ,  C07D405/12 ,  C07D401/14 ,  C07D239/48 ,  C07D403/12 ,  A61K31/506 ,  A61P37/00 ,  A61P29/00

CPC classification number: A61P37/00 ,  A61P29/00 ,  C07D239/48 ,  C07D239/96 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04

Abstract: This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer.

Abstract translation: 本发明涉及某些新的式（I）的嘧啶衍生物。 本发明还涉及制备式（I）化合物的方法，含有该化合物的药物或组合物或使用该化合物治疗增殖性疾病如癌症的方法。

公开(公告)号：WO2017211303A1

公开(公告)日：2017-12-14

申请号：PCT/CN2017/087471

申请日：2017-06-07

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： MA, Cunbo ,  GAO, Panliang ,  CHU, Jie ,  WU, Xinping ,  WEN, Chunwei ,  KANG, Di ,  BAI, Jinlong ,  PEI, Xiaoyan

IPC: C07D401/14 ,  C07D401/04 ,  C07D471/10 ,  C07D491/107 ,  C07D498/10 ,  A61K31/506 ,  A61K31/537 ,  A61P35/00 ,  A61P9/00 ,  A61P19/00 ,  A61P21/00

Abstract: Provided are certain pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract translation: 作为式（I）所示的SHP2抑制剂的某些吡嗪衍生物（I），其合成及其用于治疗SHP2介导的病症的用途。 更具体地说，提供了用作SHP2抑制剂的稠合杂环衍生物，制备此类化合物的方法以及治疗SHP2介导的疾病的方法。