公开(公告)号：WO2018192796A1

公开(公告)日：2018-10-25

申请号：PCT/EP2018/059081

申请日：2018-04-10

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： ZUO, Fei ,  WIMBERGER-FRIEDL, Reinhold ,  PIERIK, Anke ,  VAN LEEUWEN, Marinus, Bastiaan ,  DE LAAT, Koen

IPC: G06K9/00

Abstract: The present invention relates to detecting objects in medical images. In order to provide an improved detection of objects in medical images, a medical image detection device (10) is provided that comprises an image data input (12) and a processing unit (14). The image data input is configured to receive image data of a biological sample. The processing unit comprises a detector (16) and a classifier (18). The detector is configured to detect objects of interest in the sample by a detection in the image data of at least one predetermined object feature. The detected objects being candidate objects, wherein the candidate objects comprise true positives and possible false positives. Further, the classifier is configured to classify the possible false positives as false positives or as true positives. The classifier is a trained classifier, trained specifically to recognize the false positives of the detector.

公开(公告)号：WO2018104254A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/081425

申请日：2017-12-05

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： ZUO, Fei ,  PIERIK, Anke ,  WIMBERGER-FRIEDL, Reinhold ,  DE LAAT, Koen

IPC: G06K9/00 ,  G06K9/32

Abstract: A device for identifying a region of interest to be dissected from a biological tissue sample is presented. The device comprises an image analyzing unit which iteratively grows the region of interest from an initial size to a final size as long as a target parameter which is based on the two detected densities D 1 and D 2 and which describes the region of interest, is above a predefined target value. Preferably, the target parameter is the density ratio D 1 /D 2 of the region of interest and the first type of detected cells are tumor cells whereas the second type of cells are non-tumor cells. Furthermore, optimization or cost functions can be applied which take into account the percentage of number of cells of the first cell type and the total number of cells of the first cell type in the respective region of interest.

公开(公告)号：WO2021198340A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/058450

申请日：2021-03-31

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： IN 'T GROEN, Robertus, Leonardus, Maria ,  GIJSBERS, Gerardus, Henricus, Maria ,  ZUO, Fei ,  JOHNSON, Mark ,  CHAKRABARTI, Biswaroop ,  HIWALE, Sujitkumar ,  BERA, Deep

IPC: A61B8/08 ,  A61B5/318 ,  A61B5/684 ,  A61B8/085 ,  A61B8/4245 ,  A61B8/4416 ,  A61B8/461

Abstract: A system (10) is for performing ECG measurements and comprises a probe (12) with an integrated one or more ECG electrodes (22) and an ultrasound sensing means (18), such as a transducer arrangement. The probe thus provides a mobile ECG electrode which can be sequentially moved between a set of different locations on the body for acquiring ECG measurements from different angles relative to the heart (i.e. different 'leads'). Positioning of the probe in each required location is guided by a position guidance function which uses ultrasound data acquired by the ultrasound sensing means to locate the probe (with reference to an ultrasound body atlas (28) or map), and uses a stored set of reference body locations to guide a user with guidance information as to how to move the probe to arrive at a next target electrode location. In examples, the user may be guided through a sequence of electrode locations, with ECG data acquired at each one, thereby sequentially building up a set of standard ECG lead measurements.

公开(公告)号：WO2020035514A1

公开(公告)日：2020-02-20

申请号：PCT/EP2019/071769

申请日：2019-08-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： ZUO, Fei ,  PIERIK, Anke ,  WIMBERGER-FRIEDL, Reinhold ,  DE LAAT, Koen ,  VAN DRIEL, Marc

IPC: G06T7/00

Abstract: Currently, there is interest in applying machine learning techniques to analyse digital pathology images automatically. Machine learning techniques often rely on training with a ground-truth image input. The quality and amount of training data determines the quality of the detector, as expressed in the rate of true and false positives, and robustness against variations in the appearance of the input images. The present application proposes to obtain image data of the same sample before and after at least one re- staining step (firstly with a structure-revealing stain, and secondly with a bio marker revealing stain). Sections of the first and second image data having a good registration relationship are chosen, along with the probability of detecting a desired candidate object (such as nucleus) and the probability of the bio marker revealing stain being present annotation data suitable for training a machine learning algorithm on the first and/or the second image data is provided.

公开(公告)号：WO2014122544A1

公开(公告)日：2014-08-14

申请号：PCT/IB2014/058419

申请日：2014-01-21

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： SHAN, Caifeng ,  ZUO, Fei

IPC: A61B8/08 ,  A61B8/00

CPC classification number: A61B8/5246 ,  A61B5/4872 ,  A61B8/0858 ,  A61B8/14 ,  A61B8/4254 ,  A61B8/429 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/5207 ,  A61B8/5223

Abstract: The present invention relates to an ultrasound imaging system (100) comprising: an ultrasound probe (10) that comprises a single element ultrasound transducer (16) for transmitting an receiving ultrasound signals; a movement sensor (18) for sensing a displacement-over-time signal x(t) of a displacement (x) of the ultrasound probe (10) relative to an examination object (24) during signal acquisition; an image acquisition hardware (26) that is configured to reconstruct an M- mode ultrasound image from the received ultrasound signals, said reconstructed M-mode ultrasound image being a two-dimensional image I(t,y) comprising multiple one-dimensional depth signals of substantially constant depth (y) in the examination object (24) illustrated over time (t), wherein the image acquisition hardware (26) is further configured to map said M-mode ultrasound image I(t,y) to a two-dimensional second image I(x,y) comprising the depth signals illustrated over the displacement (x) by using the displacement-over-time signal x(t) that is sensed with the movement sensor (18); and an image analysis unit (48) that is configured to analyse said second image and to detect at least one tissue layer boundary of the examination object (24) in said second image.

Abstract translation: 本发明涉及一种超声成像系统（100），包括：超声波探头（10），其包括用于发送接收超声信号的单个元件超声换能器（16） 用于在信号采集期间相对于检查对象（24）感测超声波探头（10）的位移（x）的位移 - 时间信号x（t）的运动传感器（18） 被配置为从所接收的超声信号重构M模式超声图像的图像获取硬件（26），所述重建的M模式超声图像是包括多个一维深度信号的二维图像I（t，y） 在时间（t）上示出的检查对象（24）中具有基本上恒定的深度（y）的图像获取硬件（26）还被配置为将所述M模式超声波图像I（t，y） 通过使用由移动传感器（18）感测的位移 - 时间信号x（t），包括通过位移（x）示出的深度信号的二维第二图像I（x，y） 以及被配置为分析所述第二图像并且检测所述第二图像中的检查对象（24）的至少一个组织层边界的图像分析单元（48）。

公开(公告)号：WO2023088740A1

公开(公告)日：2023-05-25

申请号：PCT/EP2022/081211

申请日：2022-11-09

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： BRESCH, Erik ,  BOUTS, Mark Jacobus Rosalie Joseph ,  ZUO, Fei ,  VAN DER HEIDE, Esther Marjan

IPC: G06V10/82 ,  G06V40/20 ,  G06V20/52

Abstract: A computer implemented method for use in monitoring a first entity in a medical facility comprises: i) obtaining an image of the medical facility, ii) using a machine learning process to fit a first articulated model to the first entity in the image, wherein the first articulated model comprises keypoints corresponding to joints and affinity fields that indicate links between the keypoints. The method further comprises iii) determining a location or posture of the first entity in the medical facility from relative locations of fitted keypoints of the first articulated model in the image.

公开(公告)号：WO2022106269A1

公开(公告)日：2022-05-27

申请号：PCT/EP2021/081177

申请日：2021-11-10

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： VAN DER HEIDE, Esther, Marjan ,  ZUO, Fei

IPC: G11B27/031 ,  G11B27/28 ,  A61B5/00 ,  A61B5/11 ,  H04N5/232

Abstract: A device (20) and method for controlling a camera (10) are provided. The device comprises an input unit (21) configured to obtain video data from the camera; an image processing unit (22) configured to determine from the obtained video data if a particular person is present alone in a first area monitored by the camera; a control unit (23) configured to generate a control signal for controlling the camera to operate in a first monitoring mode or a second monitoring mode based on the determination by the image processing unit if the particular person is present alone in the first area monitored by the camera; and an output unit (24) configured to output the control signal to the camera.

公开(公告)号：WO2016169745A1

公开(公告)日：2016-10-27

申请号：PCT/EP2016/057178

申请日：2016-04-01

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： PIERIK, Anke ,  WIMBERGER-FRIEDL, Reinhold ,  CLOUT, Danielle Elisa Willemine ,  ZUO, Fei ,  VLUTTERS, Ruud

IPC: B41J2/205 ,  G01N1/28

CPC classification number: B41J2/04508 ,  B41J2/04586 ,  G01N1/2813 ,  G01N2001/282

Abstract: The invention relates to a printing control device (10) to control printing of a cover layer on a tissue or cell sample to be examined, a system (1) for printing of a cover layer (1) on a tissue or cell sample to be examined, a method to control printing of a cover layer on a tissue or cell sample to be examined, a computer program element for controlling such device or system for performing such method and a computer readable medium having stored such computer program element. The printing control device (10) comprises an imaging unit (11) and a printing control unit (12). The imaging unit (11) is configured to provide image data of the sample, and to determine a local image parameter from the image data. The local image parameter relates to local tissue porosity and/or a local capillary force of the sample. The printing control unit (12) is configured to control a printing parameter for printing the cover layer on the sample based on the local image parameter.

Abstract translation: 本发明涉及一种用于控制待检查的组织或细胞样品上的覆盖层的印刷的印刷控制装置（10），用于在组织或细胞样品上印刷覆盖层（1）的系统（1） 检查了用于控制要检查的组织或细胞样品上的覆盖层的印刷的方法，用于控制这种用于执行这种方法的装置或系统的计算机程序元件和具有存储这样的计算机程序元件的计算机可读介质。 打印控制装置（10）包括成像单元（11）和打印控制单元（12）。 成像单元（11）被配置为提供样本的图像数据，并且从图像数据确定局部图像参数。 局部图像参数涉及样品的局部组织孔隙度和/或局部毛细管力。 打印控制单元（12）被配置为基于本地图像参数来控制用于在样本上打印覆盖层的打印参数。

公开(公告)号：WO2014057427A1

公开(公告)日：2014-04-17

申请号：PCT/IB2013/059217

申请日：2013-10-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： ZUO, Fei ,  KOLEN, Alexander Franciscus ,  BELT, Harm Jan Willem ,  FOKKENROOD, Steven Antonie Willem ,  HARKS, Godefridus Antonius

IPC: A61B8/00 ,  A61B8/02 ,  A61B8/08

CPC classification number: A61B8/0883 ,  A61B8/02 ,  A61B8/461 ,  A61B8/463 ,  A61B8/486 ,  A61B8/5223 ,  A61B8/5284 ,  A61B8/543

Abstract: The invention relates to an ultrasound data visualization apparatus for visualizing ultrasound data, in particular, during a cardiac ablation procedure. An M-mode ultrasound image of an object (23) being preferentially a heart of a person or a feature image of the object comprising features derived from the M-mode ultrasound image and a repetitive signal like an electrocardiography signal being indicative of a repetitive cycle in the image are provided. An image frames determination unit (13) determines image frames by temporally segmenting the provided image into image frames corresponding to different repetitive cycles based on the repetitive signal, wherein a display (24) displays the image frames temporally consecutively. Since the display shows these image frames temporally consecutively, a movie-like displaying of the ultrasound data is provided, which allows for a better observation of details and changes of the object, especially of changes in cardiac tissue during an ablation procedure.

Abstract translation: 本发明涉及一种用于可视化超声数据的超声数据可视化装置，特别是在心脏消融过程中。 物体（23）的M模式超声图像优选地是人的心脏或物体的特征图像，包括从M模式超声图像导出的特征和诸如心电图信号的重复信号，其指示重复循环 在图像中提供。 图像帧确定单元（13）通过基于重复信号将所提供的图像暂时分割成对应于不同重复周期的图像帧来确定图像帧，其中显示器（24）在时间上连续显示图像帧。 由于显示器在时间上连续地显示这些图像帧，因此提供超声数据的电影状显示，这允许更好地观察对象的细节和变化，特别是在消融过程期间心脏组织的变化。

公开(公告)号：WO2020126844A1

公开(公告)日：2020-06-25

申请号：PCT/EP2019/084946

申请日：2019-12-12

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： IN 'T GROEN, Robertus, Leonardus, Maria ,  ZUO, Fei ,  JOHNSON, Mark, Thomas ,  BERA, Deep

IPC: A61B8/00

Abstract: An ultrasound transducer unit (12), e.g. probe, is configured with a friction guiding function. The transducer unit (12) comprises a vibration generating means (20) at a tissue contact area, and has means for sensing a sliding direction of the transducer unit across a tissue surface (42) at which the contact area is incident. The tissue surface may be an external skin surface or an internal tissue surface, e.g. in case of a catheter. A control means is operable to control the vibration of the vibration generator to adjust a level of friction at the tissue contact area. This is used by the control means to implement a friction guiding function for guiding a user in sliding the unit across the incident surface, e.g. toward a target location (44), based on controlling the friction level responsive to sensed sliding direction, for instance providing lower friction when sliding is in a target direction, while leaving other directions with relative higher frictional resistance.