公开(公告)号：WO2014073904A1

公开(公告)日：2014-05-15

申请号：PCT/KR2013/010135

申请日：2013-11-08

Applicant: LG LIFE SCIENCES LTD.

Inventor： LEE, Sung Bae ,  PAEK, Seung Yup ,  YOON, Sook Kyung ,  YOON, Seung Hyun ,  CHOI, Jeung Soon

IPC: C07D209/22 ,  C07D409/04 ,  A61K31/404 ,  A61P3/10

CPC classification number: C07D471/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D231/56 ,  C07D235/26 ,  C07D249/18 ,  C07D261/20 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06

Abstract: The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.

Abstract translation: 本发明涉及具有GPR40受体激动剂活性的新型化合物，其能促进胰岛素分泌并抑制葡萄糖负荷后的血糖升高，从而可用于治疗糖尿病及其并发症，其制备方法和药物组合物含有它们作为 有效成分。

公开(公告)号：WO2014129796A1

公开(公告)日：2014-08-28

申请号：PCT/KR2014/001336

申请日：2014-02-19

Applicant: LG LIFE SCIENCES LTD.

Inventor： PAEK, Seung Yup ,  LEE, Sung Bae ,  PARK, Deok Seong ,  LEE, Won Hyung

IPC: C07D413/04 ,  C07D271/12 ,  A61K31/4245 ,  A61P37/00

CPC classification number: C07D413/14 ,  C07D209/08 ,  C07D209/30 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D413/04 ,  C07D471/04

Abstract: The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

Abstract translation: 本发明涉及可以有效地用于治疗自身免疫性疾病的鞘氨醇-1-磷酸受体激动剂的新颖的式1化合物，其制备方法以及包含该化合物作为活性成分的药物组合物。 根据本发明的化合物对广泛的自身免疫性疾病和包括复发性多发性硬化的慢性炎性疾病有效，也可用于治疗或预防免疫调节障碍。

公开(公告)号：WO2009025477A1

公开(公告)日：2009-02-26

申请号：PCT/KR2008/004783

申请日：2008-08-18

Applicant: LG LIFE SCIENCES LTD. ,  KIM, Soon Ha ,  KIM, Hyoung Jin ,  KOO, Sun Young ,  LEE, Sung Bae ,  PARK, Heui Sul ,  YOON, Seung Hyun ,  PAEK, Seung Yup ,  KWAK, Hyo Shin ,  SEO, Dong Ook ,  PARK, Eok

Inventor： KIM, Soon Ha ,  KIM, Hyoung Jin ,  KOO, Sun Young ,  LEE, Sung Bae ,  PARK, Heui Sul ,  YOON, Seung Hyun ,  PAEK, Seung Yup ,  KWAK, Hyo Shin ,  SEO, Dong Ook ,  PARK, Eok

IPC: C07D417/04 ,  C07D209/10 ,  A61K31/404 ,  A61P1/16 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10 ,  A61P31/00 ,  A61P35/00 ,  A61P9/00

CPC classification number: C07D417/06 ,  A61K31/404 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/65586

Abstract: The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

Abstract translation: 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。