公开(公告)号：WO2014073904A1

公开(公告)日：2014-05-15

申请号：PCT/KR2013/010135

申请日：2013-11-08

Applicant: LG LIFE SCIENCES LTD.

Inventor： LEE, Sung Bae ,  PAEK, Seung Yup ,  YOON, Sook Kyung ,  YOON, Seung Hyun ,  CHOI, Jeung Soon

IPC: C07D209/22 ,  C07D409/04 ,  A61K31/404 ,  A61P3/10

CPC classification number: C07D471/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D231/56 ,  C07D235/26 ,  C07D249/18 ,  C07D261/20 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06

Abstract: The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.

Abstract translation: 本发明涉及具有GPR40受体激动剂活性的新型化合物，其能促进胰岛素分泌并抑制葡萄糖负荷后的血糖升高，从而可用于治疗糖尿病及其并发症，其制备方法和药物组合物含有它们作为 有效成分。

公开(公告)号：WO2010027236A2

公开(公告)日：2010-03-11

申请号：PCT/KR2009/005073

申请日：2009-09-08

Applicant: LG LIFE SCIENCES LTD. ,  LEE, Chang Seok ,  LEE, Tae Hee ,  YOON, Sook Kyung ,  CHOI, Jeung Soon ,  JANG, Yong Jin ,  KIM, Sung Wook ,  CHANG, Hye Kyung ,  PARK, Mi Jeong ,  KIM, Tae Hun ,  AHN, Young Ha ,  PARK, Hee Dong ,  PARK, Hyun Jung ,  LIM, Dong Chul ,  LEE, Joo Youn ,  LEE, Sung Hack ,  PARK, Wan Su ,  OH, Yeong Soo

Inventor： LEE, Chang Seok ,  LEE, Tae Hee ,  YOON, Sook Kyung ,  CHOI, Jeung Soon ,  JANG, Yong Jin ,  KIM, Sung Wook ,  CHANG, Hye Kyung ,  PARK, Mi Jeong ,  KIM, Tae Hun ,  AHN, Young Ha ,  PARK, Hee Dong ,  PARK, Hyun Jung ,  LIM, Dong Chul ,  LEE, Joo Youn ,  LEE, Sung Hack ,  PARK, Wan Su ,  OH, Yeong Soo

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D519/00

Abstract: The present invention relates to a fused heterocyclic compound having the Formula 1, which is useful as a platelet aggregation inhibitor, a method for preparing the same, and a pharmaceutical composition for inhibiting platelet aggregation comprising the same.

Abstract translation: 本发明涉及具有式1的稠合杂环化合物，其可用作血小板聚集抑制剂，其制备方法和包含其的用于抑制血小板聚集的药物组合物。

公开(公告)号：WO2005030709A1

公开(公告)日：2005-04-07

申请号：PCT/KR2004/002523

申请日：2004-10-01

Applicant: LG Life Sciences Ltd. ,  ProMediTech, Inc. ,  OH, Yeong Soo ,  CHOI, Deog-Young ,  CHO, Young Lag ,  YOON, Sook Kyung ,  SEO, Sang Won ,  LIM, Dongchul ,  MIN, Kyeongsik ,  LEE, Tae-Soo ,  LEE, Sun Hwa ,  CHUNG, Kyung Ha ,  KIM, Byeong Moon ,  BAE, Sung Jin ,  LEE, Jong Sun ,  LEE, Dae-won ,  JEONG, Moses

Inventor： OH, Yeong Soo ,  CHOI, Deog-Young ,  CHO, Young Lag ,  YOON, Sook Kyung ,  SEO, Sang Won ,  LIM, Dongchul ,  MIN, Kyeongsik ,  LEE, Tae-Soo ,  LEE, Sun Hwa ,  CHUNG, Kyung Ha ,  KIM, Byeong Moon ,  BAE, Sung Jin ,  LEE, Jong Sun ,  LEE, Dae-won ,  JEONG, Moses

IPC: C07C311/46

CPC classification number: C07D263/06 ,  C07C311/08 ,  C07C311/13 ,  C07C311/18 ,  C07C311/21 ,  C07C311/35 ,  C07C311/44 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/76 ,  C07D231/12 ,  C07D261/04 ,  C07D275/02 ,  C07D277/54 ,  C07D279/02 ,  C07D307/33 ,  C07D307/52 ,  C07D317/58 ,  C07D333/28 ,  C07D333/34

Abstract: The present invention relates to novel derivatives of sulfone amide of Formula 1 as defined in this disclosure which inhibit the activity of BACE (or beta-secretase). These sulfone amide derivatives are useful for the treatment and prevention of Alzheimer's disease and related diseases caused by production of beta-amyloid, by inhibiting the activity of BACE.

Abstract translation: 本发明涉及抑制BACE（或β-分泌酶）活性的本公开中定义的式1的砜酰胺的新衍生物。 这些砜酰胺衍生物可用于通过抑制BACE的活性来治疗和预防阿尔茨海默病和由β-淀粉样蛋白的产生引起的相关疾病。