公开(公告)号：WO2017058784A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/053943

申请日：2016-09-27

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD

Inventor： REN, Bing ,  DIXON, Jesse ,  SELVARAJ, Siddarth

IPC: C12Q1/68 ,  G06F19/26

CPC classification number: C12Q1/68 ,  C12Q1/6841 ,  G06F19/18 ,  G06F19/26 ,  C12Q2521/301 ,  C12Q2523/101 ,  C12Q2563/131

Abstract: This invention relates to methods and kits for typing and assembling discontinuous genomic elements.

Abstract translation: 本发明涉及用于分型和组装不连续基因组元件的方法和试剂盒。

公开(公告)号：WO2015010051A1

公开(公告)日：2015-01-22

申请号：PCT/US2014/047243

申请日：2014-07-18

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH

Inventor： REN, Bing ,  SELVARAJ, Siddarth ,  DIXON, Jesse

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12Q2523/101 ,  C12Q2535/122

Abstract: The present invention relates to methods for haplotype determination and, m particular, haplotype determination at the whole genome level as well as targeted haplotype determination.

Abstract translation: 本发明涉及用于单倍型测定的方法，特别地，涉及整个基因组水平的单体型确定以及目标单体型确定。

公开(公告)号：WO2020186240A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/022812

申请日：2020-03-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LUDWIG INSTITUTE FOR CANCER RESEARCH

Inventor： MISCHEL, Paul, S. ,  REN, Bing ,  VINEET, Bafna ,  CHOWDHRY, Sudhir

IPC: A61K31/455 ,  C12N5/09 ,  A61P35/00

Abstract: There are provided, inter alia , methods for treatment of cancer. The methods include means of identifying the NAD biosynthetic pathway on which depend cancer cells in a tumor, in a subject suffering from cancer. The methods further include administering to a subject in need a therapeutically effective amount of an inhibitor of the NMRK1 enzyme pathway to a tumor where the cancer cells are dependent of the NAD salvage pathway, allowing to lower the of dose FK866 administered to the subject. The methods also include administering to a subject in need a therapeutically effective amount of a bacterial inhibitor of NADSYN1 to a tumor where the cancer cells depend on the Preiss Handler pathway.

公开(公告)号：WO2021262671A2

公开(公告)日：2021-12-30

申请号：PCT/US2021/038409

申请日：2021-06-22

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD

Inventor： REN, Bing ,  ZHU, Chenxu

IPC: C12Q1/6806 ,  C12Q1/6869 ,  G16B5/00 ,  C12Q1/6853

Abstract: The present invention relates to methods for the joint analysis of regulation of gene expression and gene expression in single cells. Provided are methods for obtaining gene expression information for a single nucleus, the methods comprising deriving a DNA library from the genomic DNA in one or more nuclei and deriving an RNA library from the RNA in one or more nuclei, sequencing the molecules in the RNA library and the DNA library, and correlating the RNA library and the DNA library for each of the one or more nuclei.

公开(公告)号：WO2009055011A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/012086

申请日：2008-10-24

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. ,  REN, Bing ,  HEINTZMAN, Nathaniel, David ,  HAWKINS, Raymond, David ,  HON, Gary, Chung

Inventor： REN, Bing ,  HEINTZMAN, Nathaniel, David ,  HAWKINS, Raymond, David ,  HON, Gary, Chung

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: It has been discovered that enhancer signatures distinguish enhancer elements from other regulatory elements and that the characteristic enhancer signatures vary in a cell-type specific manner. These discoveries provide the basis for novel methods of predicting, diagnosing and monitoring of diseases, particularly cancer.

Abstract translation: 已经发现，增强子特征将增强子元件与其他调控元件区分开，并且特征增强子特征以细胞类型特异性方式变化。 这些发现为疾病，特别是癌症的预测，诊断和监测的新方法提供了依据。

公开(公告)号：WO2020123530A1

公开(公告)日：2020-06-18

申请号：PCT/US2019/065515

申请日：2019-12-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LUDWIG INSTITUTE FOR CANCER RESEARCH ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： MISCHEL, Paul ,  REN, Bing ,  TURNER, Kristen ,  WU, Sihan ,  BAFNA, Vineet ,  NGUYEN, Nam ,  CHANG, Howard

IPC: A61P35/00 ,  C12N15/11 ,  C12N15/12 ,  C12Q1/68

Abstract: Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression and chromatin structure of extrachromosomal oncogenes in cancer cells.

公开(公告)号：WO2018045137A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/049549

申请日：2017-08-31

Applicant: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD

Inventor： REN, Bing ,  YU, Miao ,  FANG, Rongxin

IPC: C07H21/04 ,  C12N15/10 ,  C12N15/11 ,  C12Q1/68 ,  C40B40/08 ,  G06F19/10

Abstract: Methods and kits for genome-wide identification of chromatin interactions in a cell are provided.

Abstract translation: 提供了用于全细胞染色质相互作用鉴定的方法和试剂盒。