公开(公告)号：WO1996011258A1

公开(公告)日：1996-04-18

申请号：PCT/US1995013196

申请日：1995-10-04

Applicant: MICROCARB, INC.

Inventor： MICROCARB, INC. ,  PACE, John, L. ,  WALKER, Richard, I. ,  FREY, Steven, M.

IPC: C12N01/00

CPC classification number: A61K39/105 ,  A61K39/025 ,  A61K39/09 ,  A61K39/107 ,  A61K2039/55555 ,  C12N1/20 ,  C12Q1/045 ,  C12Q1/18 ,  Y02A50/47 ,  Y02A50/472

Abstract: Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced enteric bacteria. Also methods for using the antigenically enhanced bacteria are also disclosed, as well as vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof are provided by Helicobacter species. Also there are other enteric bacteria which are useful for the disclosed invention. One type, Campylobacter jejuni is graphically depicted wherein the results of high-performance liquid chromatography of monosaccharides from surface extract hydrolysates of C. jejuni are shown.

Abstract translation: 公开了使用体外方法诱导或增强肠细菌抗原或毒力因子表达的方法。 因此，该方法产生抗原性增强的肠细菌。 还公开了使用抗原性增强的细菌的方法，以及含有肠细菌的疫苗。 具体地，整个肠道细菌或其组分由幽门螺杆菌属物种提供。 还有其它肠道细菌可用于所公开的发明。 一种类型的空肠弯曲杆菌被图形化，其中显示了来自空肠弯曲杆菌的表面提取物水解产物的单糖的高效液相色谱的结果。

公开(公告)号：WO1996011257A1

公开(公告)日：1996-04-18

申请号：PCT/US1995012986

申请日：1995-10-04

Applicant: MICROCARB, INC.

Inventor： MICROCARB, INC. ,  PACE, John, L. ,  WALKER, Richard, I. ,  FREY, Steven, M.

IPC: C12N01/00

CPC classification number: A61K39/105 ,  A61K39/107 ,  A61K2039/55555 ,  C12N1/20 ,  C12Q1/045 ,  C12Q1/18 ,  C12R1/01 ,  G01N33/56916 ,  G01N33/56922 ,  G01N2333/25 ,  G01N2469/20 ,  Y02A50/47 ,  Y02A50/472 ,  Y10S424/802 ,  Y10S435/822 ,  Y10S435/96 ,  Y10S435/961 ,  Y10S435/975

Abstract: Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigencially enhanced enteric bacteria. Also methods for using the antigenically enhanced bacteria are also disclosed, as well as vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof are provided by Helicobacter species. Also there are other enteric bacteria which are useful for the disclosed invention. One type, Campylobacter jejuni is graphically depicted wherein the results of high-performance liquid chromatography of monosaccharides from surface extract hydrolysates of C.jejuni are shown.

Abstract translation: 公开了使用体外方法诱导或增强肠细菌抗原或毒力因子表达的方法。 因此，该方法产生抗原性增强的肠细菌。 还公开了使用抗原性增强的细菌的方法，以及含有肠细菌的疫苗。 具体地，整个肠道细菌或其组分由幽门螺杆菌属物种提供。 还有其它肠道细菌可用于所公开的发明。 图示了一种类型的空肠弯曲杆菌，其中显示了来自C.jejuni的表面提取物水解产物的单糖的高效液相色谱的结果。