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    RECEPTOR CONJUGATES FOR TARGETING DRUGS AND OTHER AGENTS
    1.
    发明申请
    RECEPTOR CONJUGATES FOR TARGETING DRUGS AND OTHER AGENTS 审中-公开
    受试者接种药物及其他药剂

    公开(公告)号：WO1993002709A1

    公开(公告)日：1993-02-18

    申请号：PCT/US1991005422

    申请日：1991-07-31

    Applicant: MICROCARB INC.

    Inventor： MICROCARB INC. ,  KRIVAN, Howard, C. ,  BLOMBERG, Arne, Lennart, Ingemar

    IPC: A61K47/48

    CPC classification number: A61K47/6911 ,  A61K47/6425

    Abstract: A variety of conjugates, comprising at least one agent coupled to at least one receptor which binds a microorganism, are provided. Preferred agents include anti-infectives, such as antibiotics and synthetic drugs. Uses of the conjugates include as in vitro inhibitors and as therapeutic agents, e.g., for the treatment of infections due to pathogenic microorganisms.

    Abstract translation: 提供了包含与至少一种结合微生物的受体偶联的至少一种试剂的多种缀合物。 优选的试剂包括抗感染剂，例如抗生素和合成药物。 缀合物的用途包括作为体外抑制剂和治疗剂，例如用于治疗由致病微生物引起的感染。

    ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE
    2.
    发明申请
    ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE 审中-公开
    用于肝炎流行病的粘蛋白 - 低聚葡萄糖结合疫苗（ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE

    公开(公告)号：WO1992010936A1

    公开(公告)日：1992-07-09

    申请号：PCT/US1991009693

    申请日：1991-12-20

    Applicant: MICROCARB, INC.

    Inventor： MICROCARB, INC. ,  KRIVAN, Howard, C. ,  SAMUEL, James, E. ,  NORBERG, Nils, Thomas

    IPC: A01N43/04

    CPC classification number: C07H15/04 ,  A61K39/102 ,  A61K2039/6068 ,  A61K2039/627 ,  C07H15/08 ,  C07H15/18 ,  C07K14/285

    Abstract: Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol phosphate (PRP) oligosaccharides and intermediates useful for their synthesis, and methods of making and using these materials. The conjugates comprise a PRP fragment, preferably a synthetic oligosaccharide, coupled to an H. influenzae adhesin protein. The invention further comprises purified H. influenzae adhesin proteins and novel PRP oligosaccharides. The invention also comprises methods of producing these materials and using them in a vaccine to protect humans and other mammals against H. influenzae infection.

    Abstract translation: 本文公开了免疫原性多糖-H。 流感嗜血杆菌粘附素蛋白质缀合物，纯化的流感嗜血杆菌粘附素蛋白质和相关蛋白质和多肽，可用于产生蛋白质的DNA，合成的聚核糖核糖核酸寡聚糖（PRP）寡糖和可用于其合成的中间体，以及制备和使用这些材料的方法。 缀合物包含与流感嗜血杆菌粘附素蛋白偶联的PRP片段，优选合成寡糖。 本发明还包括纯化的流感嗜血杆菌粘附素蛋白和新型PRP寡糖。 本发明还包括生产这些材料并在疫苗中使用它们以保护人类和其他哺乳动物免于流感嗜血杆菌感染的方法。

    NUTRIENT PHOSPHOLIPIDS FOR PATHOGENIC BACTERIA
    3.
    发明申请
    NUTRIENT PHOSPHOLIPIDS FOR PATHOGENIC BACTERIA 审中-公开
    营养细菌致病细菌

    公开(公告)号：WO1993022423A1

    公开(公告)日：1993-11-11

    申请号：PCT/US1993004053

    申请日：1993-04-29

    Applicant: MICROCARB INC.

    Inventor： MICROCARB INC. ,  KRIVAN, Howard, C.

    IPC: C12N01/20

    CPC classification number: C12N1/20 ,  C12N1/38 ,  C12N15/01

    Abstract: A variety of methods are provided for growing bacterial cells on lipids, acidic lipids, phospholipids, phosphatidylserine, or mucus, egg or milk fractions or subfractions. Pathogenic bacteria are preferred and include bacteria such as Salmonella, Yersinia, Shigella, Campylobacter, Helicobacter, Pseudomonas, Streptococcus, Staphylococcus, E. coli, Haemophilus, Mycobacterium, Proteus, Klebsiella, Neisseria, Branhamella, Bacteroides, Listeria, Enterococci, Vibrio, Yersinia, Bordetella, Clostridium, Treponema, and Mycoplasma. The present invention also discloses methods for the selection of mutant strains which cannot grow in animals and use of such mutants as host cells for expression of cloned DNA molecules. In addition, methods are provided for the isolation of proteins whose expression is induced or enhanced by growth in the presence of phosphatidylserine or compositions containing phosphatidylserine. Such proteins have a number of uses, including as components of vaccines and as diagnostic markers. The present invention also provides methods for preparing bacteria or fractions thereof for use within cellular or acellular vaccines.

    Abstract translation: 提供了多种方法用于在脂质，酸性脂质，磷脂，磷脂酰丝氨酸或粘液，蛋或牛奶级分或亚级分上生长细菌细胞。 致病细菌是优选的，并且包括细菌如沙门氏菌，耶尔森氏菌，志贺氏杆菌，弯曲杆菌，幽门螺杆菌，假单胞菌属，链球菌属，葡萄球菌属，大肠杆菌，嗜血杆菌，分枝杆菌，变形杆菌，克雷伯菌，奈瑟氏球菌，布兰汉菌，拟杆菌属，李斯特氏菌，肠球菌，弧菌属，耶尔森氏菌 ，博德氏菌属，梭菌属，密螺旋体和支原体。 本发明还公开了选择不能在动物中生长的突变菌株和使用这种突变体作为宿主细胞表达克隆的DNA分子的方法。 此外，提供了用于分离其表达在磷脂酰丝氨酸或含有磷脂酰丝氨酸的组合物存在下通过生长诱导或增强的蛋白质分离的方法。 这些蛋白质具有多种用途，包括疫苗的组分和诊断标记。 本发明还提供了在细胞或细胞疫苗中使用的细菌或其部分的制备方法。

    METHODS FOR PRODUCING ENHANCED ANTIGENIC ENTERIC BACTERIA AND VACCINES COMPRISING SAME
    5.
    发明申请
    METHODS FOR PRODUCING ENHANCED ANTIGENIC ENTERIC BACTERIA AND VACCINES COMPRISING SAME 审中-公开
    生产增强型肠内营养细菌的方法及其包含的疫苗

    公开(公告)号：WO1996011258A1

    公开(公告)日：1996-04-18

    申请号：PCT/US1995013196

    申请日：1995-10-04

    Applicant: MICROCARB, INC.

    Inventor： MICROCARB, INC. ,  PACE, John, L. ,  WALKER, Richard, I. ,  FREY, Steven, M.

    IPC: C12N01/00

    CPC classification number: A61K39/105 ,  A61K39/025 ,  A61K39/09 ,  A61K39/107 ,  A61K2039/55555 ,  C12N1/20 ,  C12Q1/045 ,  C12Q1/18 ,  Y02A50/47 ,  Y02A50/472

    Abstract: Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced enteric bacteria. Also methods for using the antigenically enhanced bacteria are also disclosed, as well as vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof are provided by Helicobacter species. Also there are other enteric bacteria which are useful for the disclosed invention. One type, Campylobacter jejuni is graphically depicted wherein the results of high-performance liquid chromatography of monosaccharides from surface extract hydrolysates of C. jejuni are shown.

    Abstract translation: 公开了使用体外方法诱导或增强肠细菌抗原或毒力因子表达的方法。 因此，该方法产生抗原性增强的肠细菌。 还公开了使用抗原性增强的细菌的方法，以及含有肠细菌的疫苗。 具体地，整个肠道细菌或其组分由幽门螺杆菌属物种提供。 还有其它肠道细菌可用于所公开的发明。 一种类型的空肠弯曲杆菌被图形化，其中显示了来自空肠弯曲杆菌的表面提取物水解产物的单糖的高效液相色谱的结果。

    ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE
    6.
    发明申请
    ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE 审中-公开
    用于肝炎流行病的粘蛋白 - 低聚葡萄糖结合疫苗（ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE

    公开(公告)号：WO1994000149A1

    公开(公告)日：1994-01-06

    申请号：PCT/US1993006016

    申请日：1993-06-22

    Applicant: MICROCARB INC. ,  KRIVAN, Howard, C. ,  SAMUELS, James, E. ,  NORBERG, Nils, Thomas

    Inventor： MICROCARB INC.

    IPC: A61K39/00

    CPC classification number: C07H15/04 ,  A61K39/102 ,  A61K2039/6068 ,  A61K2039/627 ,  C07H3/06 ,  C07H15/08 ,  C07H15/18 ,  C07K14/285 ,  C07K2319/00

    Abstract: Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol phosphate (PRP) oligosaccharides and intermediates useful for their synthesis, and methods of making and using these materials. The conjugates comprise a PRP fragment, preferably a synthetic oligosaccharide, coupled to an H. influenzae adhesin protein. The invention further comprises purified H. influenzae adhesin proteins and novel PRP oligosaccharides. The invention also comprises methods of producing these materials and using them in a vaccine to protect humans and other mammals against H. influenzae infection.

    Abstract translation: 本文公开了免疫原性多糖-H。 流感嗜血杆菌粘附素蛋白质缀合物，纯化的流感嗜血杆菌粘附素蛋白质和相关蛋白质和多肽，可用于产生蛋白质的DNA，合成的聚核糖核糖核酸寡聚糖（PRP）寡糖和可用于其合成的中间体，以及制备和使用这些材料的方法。 缀合物包含与流感嗜血杆菌粘附素蛋白偶联的PRP片段，优选合成寡糖。 本发明还包括纯化的流感嗜血杆菌粘附素蛋白和新型PRP寡糖。 本发明还包括生产这些材料并在疫苗中使用它们以保护人类和其他哺乳动物免于流感嗜血杆菌感染的方法。

    MONOSPECIFIC POLYCLONAL ANTIBODIES TO SHIGA-LIKE TOXINS
    7.
    发明申请
    MONOSPECIFIC POLYCLONAL ANTIBODIES TO SHIGA-LIKE TOXINS 审中-公开
    单性多核苷酸抗体对SHIGA-like毒素

    公开(公告)号：WO1993018784A1

    公开(公告)日：1993-09-30

    申请号：PCT/US1993002864

    申请日：1993-03-25

    Applicant: MICROCARB, INC.

    Inventor： MICROCARB, INC. ,  KRIVAN, Howard, C. ,  SAMUEL, James, E.

    IPC: A61K37/04

    CPC classification number: C07K14/245 ,  A61K38/00 ,  C07K16/1232

    Abstract: Disclosed herein are high titer, monospecific, polyclonal antibodies to Shiga-like toxins. Also disclosed are methods for producing such antibodies, compositions containing them, and methods for the diagnosis, prevention, and treatment of diseases caused by Shiga-like toxins. These include hemorrhagic colitis and hemolytic uremic syndrome in humans, edema disease in swine, and calf diarrhea in cattle.

    Abstract translation: 本文公开了针对志贺样毒素的高滴度，单特异性，多克隆抗体。 还公开了制备这种抗体的方法，含有它们的组合物，以及用于诊断，预防和治疗由志贺样毒素引起的疾病的方法。 这些包括人类出血性结肠炎和溶血性尿毒综合征，猪中的水肿病和牛的小腿腹泻。

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