公开(公告)号：WO2018094385A1

公开(公告)日：2018-05-24

申请号：PCT/US2017062760

申请日：2017-11-21

Applicant: NANOSTRING TECH INC

Inventor： HOANG MARGARET ,  GREGORY MARK ,  KIM DAE ,  DUNAWAY DWAYNE L ,  MANRAO ELIZABETH A ,  BEECHEM JOSEPH M ,  KHAFIZOV RUSTEM ,  KORUKONDA SANGHAMITHRA ,  DENG YI

IPC: C12Q1/6869 ,  C12Q1/6874

CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12Q2563/107 ,  C12Q2563/179 ,  C12Q2565/101 ,  C12Q2565/518

Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.

公开(公告)号：WO2017041084A3

公开(公告)日：2017-04-27

申请号：PCT/US2016050376

申请日：2016-09-06

Applicant: NANOSTRING TECH INC

Inventor： KIM DAE ,  ROSS PAUL MARTIN ,  MEREDITH GAVIN ,  MANRAO ELIZABETH A

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q2525/161 ,  C12Q2525/313 ,  C12Q2563/179 ,  C12Q2565/514 ,  C12Q2565/519

Abstract: The present invention relates to, among other things, polymer strands, probes, compositions, methods, and kits for enabling accurate and robust enzyme- and amplification-free detection of DNA and RNA with single base resolution (e.g., detection of a single nucleotide polymorphism (SNP), an insertion, and a deletion). The compositions, methods, and kits may further provide simultaneous detection of DNA and/or RNA and protein targets.

Abstract translation: 本发明尤其涉及聚合物链，探针，组合物，方法和试剂盒，用于实现具有单碱基分辨率的DNA和RNA的准确和强大的无酶和无扩增检测（例如，检测单核苷酸多态性 （SNP），插入和删除）。 组合物，方法和试剂盒可进一步提供DNA和/或RNA和蛋白质靶标的同时检测。