公开(公告)号：WO2016193977A2

公开(公告)日：2016-12-08

申请号：PCT/IL2016/050566

申请日：2016-06-02

Applicant: NEVIAH GENOMICS LTD. ,  COMPUGEN LTD.

Inventor： YARDEN, Ganit ,  WOOL, Assaf

IPC: G01N33/50 ,  C12Q1/68

CPC classification number: G01N33/5067 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5014 ,  G01N33/5023

Abstract: Methods of predicting hepatotoxicity of a compound by providing an in vitro hepatocyte culture system capable of expressing a panel of genes, wherein the culture may be incubated with the compound or compounds to be screened and the expression level of the panel of genes measured is described herein. By comparing the expression level of the panel of genes in the culture system exposed to the compound(s) being screened with the gene expression of the same panel of genes in a control culture system, hepatotoxicity of the compound(s) is able to be predicted.

Abstract translation: 通过提供能够表达一组基因的体外肝细胞培养系统来预测化合物的肝毒性的方法，其中可以将培养物与待筛选的化合物或化合物孵育，并且本文描述测量的基因组的表达水平 。 通过比较暴露于被筛选的化合物的培养系统中的基因组的表达水平与对照培养系统中同一组基因的基因表达，化合物的肝毒性能够 预料到的。

公开(公告)号：WO2012110999A1

公开(公告)日：2012-08-23

申请号：PCT/IL2012/000073

申请日：2012-02-12

Applicant: COMPUGEN LTD ,  PINCHAS, Akiva ,  EDELHEIT-FLOHR, Sarit ,  BAZAK, Lily ,  LEVINE, Zurit ,  TOPORIK, Amir ,  LEVY, Ofer ,  ZEKHARYA, Tomer ,  WOOL, Assaf

Inventor： PINCHAS, Akiva ,  EDELHEIT-FLOHR, Sarit ,  BAZAK, Lily ,  LEVINE, Zurit ,  TOPORIK, Amir ,  LEVY, Ofer ,  ZEKHARYA, Tomer ,  WOOL, Assaf

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present invention discloses markers useful in predicting the responsiveness of a subject having, or at risk of developing rheumatoid arthritis (RA) to treatment with anti- TNFα agents. Particularly, the present invention discloses the allelic configuration of the CD6 gene and/or the STXBP6 gene which is indicative of the degree of responsiveness to anti-TNFα treatment of RA.

Abstract translation: 本发明公开了用于预测具有或具有发展类风湿性关节炎（RA）的风险的受试者对抗TNFα剂治疗的反应性的标记。 特别地，本发明公开了CD6基因和/或STXBP6基因的等位基因构型，其指示针对RA的抗TNFα治疗的反应程度。

公开(公告)号：WO2005072340A2

公开(公告)日：2005-08-11

申请号：PCT/US2005/002350

申请日：2005-01-27

Applicant: COMPUGEN LTD. ,  COMPUGEN INC. ,  AYALON-SOFFER, Michal ,  LEVINE, Zurit ,  SELLA-TAVOR, Osnat ,  DIBER, Alex ,  SHEMESH, Ronen ,  TOPORIK, Amir ,  ROTMAN, Galit ,  NEMZER, Sergey ,  ROSENBERG, Avi ,  DAHARY, Dvir ,  WOOL, Assaf ,  COJOCARU, Gad, S. ,  AKIVA, Pinchas ,  POLLOCK, Sarah ,  SAVITSKY, Kinneret ,  BERNSTEIN, Jeanne

Inventor： AYALON-SOFFER, Michal ,  LEVINE, Zurit ,  SELLA-TAVOR, Osnat ,  DIBER, Alex ,  SHEMESH, Ronen ,  TOPORIK, Amir ,  ROTMAN, Galit ,  NEMZER, Sergey ,  ROSENBERG, Avi ,  DAHARY, Dvir ,  WOOL, Assaf ,  COJOCARU, Gad, S. ,  AKIVA, Pinchas ,  POLLOCK, Sarah ,  SAVITSKY, Kinneret ,  BERNSTEIN, Jeanne

IPC: C07K14/47

CPC classification number: C07K14/47 ,  Y10S435/81

Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and phamaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.

Abstract translation: 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。

公开(公告)号：WO2010010551A2

公开(公告)日：2010-01-28

申请号：PCT/IL2009/000709

申请日：2009-07-20

Applicant: COMPUGEN LTD. ,  KLIGER, Yossef ,  BORUKHOV, Itamar ,  LEVY, Ofer ,  TIRAN, Zohar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TOPORIK, Amir

Inventor： KLIGER, Yossef ,  BORUKHOV, Itamar ,  LEVY, Ofer ,  TIRAN, Zohar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TOPORIK, Amir

IPC: C07K14/515

CPC classification number: C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

Abstract: In at least some embodiments, the subject invention provides angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

Abstract translation: 在至少一些实施方案中，本发明提供血管生成素衍生的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和用于制备药物的用途，治疗广泛的病症，病症和 疾病，编码它们的核苷酸序列，针对其表位的抗体和包含它们的融合蛋白。

公开(公告)号：WO2009093246A2

公开(公告)日：2009-07-30

申请号：PCT/IL2009/000093

申请日：2009-01-22

Applicant: COMPUGEN LTD. ,  KLIGER, Yossef ,  LEVY, Ofer ,  BORUKHOV, Itamar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TIRAN, Zohar ,  OREN, Anat ,  TOPORIK, Amir

Inventor： KLIGER, Yossef ,  LEVY, Ofer ,  BORUKHOV, Itamar ,  WOOL, Assaf ,  SCHREIBER, Ehud ,  AMIR, Anat ,  LEVINE, Zurit ,  TIRAN, Zohar ,  OREN, Anat ,  TOPORIK, Amir

IPC: A61K38/17 ,  C07K14/775 ,  C07K16/18

CPC classification number: C07K14/775 ,  A61K38/00

Abstract: The subject invention provides clusterin-derived peptides or homologs or derivatives thereof, pharmaceutical composition comprising them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins comprising them.

Abstract translation: 本发明提供簇蛋白衍生的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，用于治疗广泛的病症，疾病和疾病的方法，编码 它们是针对其表位的抗体和包含它们的融合蛋白。

公开(公告)号：WO2009019531A3

公开(公告)日：2009-02-12

申请号：PCT/IB2007/004634

申请日：2007-09-18

Applicant: COMPUGEN LTD ,  COHEN, Yossi ,  SHEMESH, Ronen ,  TOPORIK, Amir ,  LEVINE, Zurit ,  WOOL, Assaf ,  DAHARY, Dvir ,  HECHT, Iris ,  BEIMAN, Merav ,  ROTMAN, Galit ,  AYALON-SOFFER, Michal

Inventor： COHEN, Yossi ,  SHEMESH, Ronen ,  TOPORIK, Amir ,  LEVINE, Zurit ,  WOOL, Assaf ,  DAHARY, Dvir ,  HECHT, Iris ,  BEIMAN, Merav ,  ROTMAN, Galit ,  AYALON-SOFFER, Michal

IPC: C07K5/103 ,  C07K14/47 ,  A61K38/07 ,  A61K38/16 ,  C07K16/18

Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

公开(公告)号：WO2009007848A2

公开(公告)日：2009-01-15

申请号：PCT/IB2008/002447

申请日：2008-07-11

Applicant: COMPUGEN LTD. ,  SHEMESH, Ronen ,  LEVINE, Zurit ,  TOPORIK, Amir ,  HERMESH, Chen ,  KLIGER, Yossi ,  GOFER, Eyal ,  WOOL, Assaf ,  DAHARY, Dvir ,  COHEN, Yossi

Inventor： SHEMESH, Ronen ,  LEVINE, Zurit ,  TOPORIK, Amir ,  HERMESH, Chen ,  KLIGER, Yossi ,  GOFER, Eyal ,  WOOL, Assaf ,  DAHARY, Dvir ,  COHEN, Yossi

IPC: C07K14/705 ,  C07K14/64 ,  A61K38/17 ,  C12N15/12

CPC classification number: C07K14/472 ,  A61K38/00 ,  C07K7/06 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C07K2317/34

Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.

Abstract translation: 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。

公开(公告)号：WO2005071059A2

公开(公告)日：2005-08-04

申请号：PCT/IL2005/000107

申请日：2005-01-27

Applicant: COMPUGEN LTD. ,  SOREK, Rotem ,  POLLOCK, Sarah ,  DIBER, Alex ,  LEVINE, Zurit ,  NEMZER, Sergey ,  KOL, Guy ,  WOOL, Assaf ,  HAVIV, Ami ,  COHEN, Yuval ,  COHEN, Yossi ,  SHEMESH, Ronen ,  SAVITSKY, Kinneret

Inventor： SOREK, Rotem ,  POLLOCK, Sarah ,  DIBER, Alex ,  LEVINE, Zurit ,  NEMZER, Sergey ,  KOL, Guy ,  WOOL, Assaf ,  HAVIV, Ami ,  COHEN, Yuval ,  COHEN, Yossi ,  SHEMESH, Ronen ,  SAVITSKY, Kinneret

IPC: C12N

CPC classification number: G06F19/22

Abstract: A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced exons, thereby identifying the alternatively spliced exons.

Abstract translation: 提供了一种识别可变剪接外显子的方法。 所述方法包括：根据至少一个序列参数对来自物种基因的多个外显子序列中的每一个进行评分，其中得分高于预定阈值的多个外显子序列的外显子序列代表可变剪接的外显子，由此鉴定可变剪接 外显子。