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    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS
    1.
    发明申请
    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS 审中-公开
    两亲性支链聚二有机硅氧烷大分子

    公开(公告)号：WO2017103792A1

    公开(公告)日：2017-06-22

    申请号：PCT/IB2016/057586

    申请日：2016-12-13

    申请人： NOVARTIS AG

    发明人： CHANG, Frank ,  HUANG, Jinyu ,  HOLLAND, Troy Vernon

    IPC分类号： G02B1/04 ,  C08F283/12

    CPC分类号： C08F290/068 ,  C08F283/124 ,  C08F2438/01 ,  C08G77/20 ,  C08G2210/00 ,  C08L2312/06 ,  G02B1/043 ,  C08F222/1006 ,  C08F220/40 ,  C08F222/38

    摘要： The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

    摘要翻译： 本发明提供一类两亲支链大分子单体及其用途。 本发明的两亲性支化聚二有机硅氧烷大分子单体由α，ω-二甲基丙烯酰基封端的聚二有机基硅氧烷乙烯基交联剂制备，该交联剂包含一个或多个含ATRP的硅氧烷单元，其具有一个具有ATRP引发剂的取代基，通过ATRP聚合一种或多种亲水乙烯基单体。 它包含至少两个各自具有最多两个末端甲基丙烯酰氧基的聚二有机硅氧烷聚合物链，各自具有可聚合或不可聚合端基的悬挂亲水聚合物链以及一个或多个亲水聚合物链作为两个聚二有机硅氧烷链之间的键。 本发明还涉及硅酮水凝胶隐形眼镜，其包含衍生自本发明的含聚二有机硅氧烷的两亲性支链大分子单体的单元。

    HYDROPHILIC COPOLYMER WITH ONE THIOL-CONTAINING TERMINAL GROUP
    5.
    发明申请
    HYDROPHILIC COPOLYMER WITH ONE THIOL-CONTAINING TERMINAL GROUP 审中-公开
    具有一个含硫端基的亲水性共聚物

    公开(公告)号：WO2018073702A1

    公开(公告)日：2018-04-26

    申请号：PCT/IB2017/056312

    申请日：2017-10-12

    申请人： NOVARTIS AG

    发明人： CHANG, Frank ,  HOLLAND, Troy Vernon ,  MOY, Thomas M.

    IPC分类号： C08F220/56 ,  C08F2/38 ,  C08F230/02 ,  C08F8/34 ,  G02B1/04

    摘要： The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

    摘要翻译： 本发明涉及一类亲水性聚合物，每种亲水性聚合物包含一个单独的含巯基末端基团。 亲水性聚合物在加热时对含氮杂环丁烷的聚合物的氮杂环丁鎓基团具有高度反应性，并且可以特别用于生产水溶性高度支化的亲水性聚合物材料，用于制造水梯度接触镜片。

    PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS
    9.
    发明申请
    PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS 审中-公开

    公开(公告)号：WO2019016695A1

    公开(公告)日：2019-01-24

    申请号：PCT/IB2018/055285

    申请日：2018-07-17

    申请人： NOVARTIS AG

    发明人： CHANG, Frank ,  JING, Feng ,  HOLLAND, Troy Vernon ,  CHIANG, Chung-Yuan ,  PRUITT, John Dallas

    IPC分类号： C08F230/02 ,  G02B1/04 ,  G02C7/04

    摘要： The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly- branched hydrophilic polymeric material and in producing water gradient contact lenses.

    WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF
    10.
    发明申请
    WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF 审中-公开
    水溶性紫外线吸收化合物及其用途

    公开(公告)号：WO2017093835A1

    公开(公告)日：2017-06-08

    申请号：PCT/IB2016/056877

    申请日：2016-11-15

    申请人： NOVARTIS AG

    发明人： CHANG, Frank ,  DESOUSA, Ryan ,  HOLLAND, Troy Vernon ,  LAREDO, Walter R.

    IPC分类号： C07D249/20 ,  B29D11/00 ,  G02B1/04

    CPC分类号： C07C225/22 ,  B29D11/00038 ,  C07C225/10 ,  C07D249/20 ,  C08F116/06 ,  G02B1/043 ,  G02C7/049 ,  G02C7/108 ,  C08L2666/70

    摘要： Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV- absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

    摘要翻译： 本文描述了含二甲基缩醛的UV吸收性化合物及其在制备适用于产生能够阻挡紫外线（“UV”）的UV吸收性隐形眼镜的UV吸收性聚乙烯醇预聚物中的用途， 辐射和任选（但优选）紫外辐射，其波长为380nm至44​​0nm，从而在一定程度上保护眼睛免受紫外线辐射和可能来自紫外线辐射的损害。 本发明还提供了紫外线吸收聚乙烯醇预聚物。