公开(公告)号：WO2013188274A3

公开(公告)日：2013-12-19

申请号：PCT/US2013/044938

申请日：2013-06-10

申请人： NOVARTIS AG ,  HOLLAND, Troy Vernon

发明人： HOLLAND, Troy Vernon ,  CHANG, Frank ,  QIU, Yongxing ,  PRUITT, John Dallas ,  CHIANG, Chung-Yuan ,  SHANKERNARAYANAN, Manivakkam J. ,  SCOTT, Robert ,  KAPOOR, Yash

IPC分类号： B29D11/00 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  G02C7/04 ,  B05D3/10

摘要： The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：WO2019016696A1

公开(公告)日：2019-01-24

申请号：PCT/IB2018/055287

申请日：2018-07-17

申请人： NOVARTIS AG

发明人： CHANG, Frank ,  JING, Feng ,  HOLLAND, Troy Vernon ,  CHIANG, Chung-Yuan ,  PRUITT, John Dallas

IPC分类号： C08F220/56 ,  C08L33/26 ,  C08L79/02

摘要： The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：WO2019116141A1

公开(公告)日：2019-06-20

申请号：PCT/IB2018/059473

申请日：2018-11-29

申请人： NOVARTIS AG

发明人： QIU, Yongxing ,  PRUITT, John Dallas ,  SAMUEL, Newton T. ,  CHIANG, Chung-Yuan ,  DRIVER-SCOTT, Angela ,  DAUENHAUER, Ciara ,  ANAND, Rita

IPC分类号： G02B1/04

摘要： A process for producing water gradient contact lenses comprises a step of heating a contact lens precursor with an anchor layer of a polyanionic polymer in an aqueous solution comprising at least one low molecular weight polyaziridine and at least one thermally- crosslinkable hydrophilic polymeric material to form an outer surface hydrogel layer which is covalently attached to the anchor layer, to convert a majority or most negatively-charged groups in the water gradient contact lens into non-charged ester groups through aziridine groups to minimize or eliminate uptake of a polycationic antimicrobial, and to crosslinked the anchor layer through a polyaziridine as a flexible crosslinker so as to enforce the durability of the outer surface hydrogel layer while having no or minimal adverse impacts on the wettability, hydrophilicity, and lubricity of the outer surface hydrogel layer on the contact lens.

公开(公告)号：WO2017145024A1

公开(公告)日：2017-08-31

申请号：PCT/IB2017/050875

申请日：2017-02-16

申请人： NOVARTIS AG

发明人： CHANG, Frank ,  DESOUSA, Ryan ,  HOLLAND, Troy Vernon ,  PRUITT, John Dallas ,  NELSON, Jared

IPC分类号： C07D249/20 ,  C07C233/37 ,  C08F20/36 ,  G02B5/20 ,  G02B5/22

CPC分类号： G02C7/108 ,  B29D11/00134 ,  B29K2105/0002 ,  C07C233/38 ,  C07D249/20 ,  C08F20/36 ,  C08F220/70 ,  C08F230/08 ,  G02B1/043 ,  G02B5/208 ,  G02B5/223 ,  G02C7/049

摘要： Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.

摘要翻译： 本文描述了水溶性UV吸收性乙烯基单体及其在制备能够阻挡紫外（“UV”）辐射和任选（但优选）紫色辐射的UV吸收性隐形眼镜中的用途 波长从380纳米到440纳米，从而在一定程度上保护眼睛免受紫外线辐射和潜在的紫外线辐射造成的损害。 本发明还提供了一种吸收紫外线的隐形眼镜。

公开(公告)号：WO2014093299A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/074043

申请日：2013-12-10

申请人： NOVARTIS AG ,  QIU, Yongxing

发明人： QIU, Yongxing ,  MEDINA, Arturo Norberto ,  PRUITT, John Dallas

IPC分类号： B29D11/00 ,  G02B11/04

CPC分类号： G02C7/04 ,  B29D11/00865 ,  B65B55/02 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

摘要： The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising.

摘要翻译： 本发明一般涉及将亲水性聚合物涂层涂覆在硅氧水凝胶隐形眼镜上以改善亲水性和润滑性的方法。 特别地，本发明涉及一种在初级包装中直接形成隐形眼镜，优选硅酮水凝胶隐形眼镜上的涂层的方法，并将涂覆的隐形眼镜保持在所述初级包装内，直到将涂覆的隐形眼镜插入 隐形眼镜用户的眼睛。 所得的硅酮水凝胶隐形眼镜具有亲水性好，润滑性好，耐久性好的涂层，也可以由患者直接从镜片包装中使用而无需洗涤和/或上升。

公开(公告)号：WO2018055491A1

公开(公告)日：2018-03-29

申请号：PCT/IB2017/055577

申请日：2017-09-14

申请人： NOVARTIS AG

发明人： QIU, Yongxing ,  PRUITT, John Dallas ,  TALLAU, Kelly Kayi ,  DRIVER-SCOTT, Angela ,  CHIANG, Chung-Yuan

IPC分类号： G02B1/04 ,  B29D11/00

CPC分类号： G02C7/04 ,  B29D11/00038 ,  B29D11/00067 ,  B29D11/00903 ,  C09D133/02 ,  C09D177/06 ,  G02B1/043 ,  G02B1/14 ,  G02C2202/16

摘要： The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.

摘要翻译： 本发明涉及一种用于制造软性隐形眼镜的方法，所述软性隐形眼镜包含硅酮水凝胶镜片主体及其上的复合涂层。 该复合涂层包括：等离子体基底涂层，其直接化学连接到硅酮水凝胶隐形眼镜的表面上，并且起到防止措施的作用，以确保疏水性硅酮水凝胶镜片材料被防止暴露于任何眼睛环境中 经过至少30天的日常使用后，包括日常使用和日常清洁/消毒; 和一个相对耐用的润滑水凝胶顶部涂层，以确保穿着舒适。 本发明的方法包括在硅酮水凝胶隐形眼镜上形成具有反应性官能团的等离子体反应性亲水聚合物混合底涂层，并将该硅酮水凝胶隐形眼镜与混合底涂层在水溶性且可热交联的水溶液中加热 亲水性聚合物材料以在其上形成稳定的润滑水凝胶涂层。 该方法对硅酮水凝胶镜片主体的机械性能具有最小的不利影响。

公开(公告)号：WO2018055490A1

公开(公告)日：2018-03-29

申请号：PCT/IB2017/055575

申请日：2017-09-14

申请人： NOVARTIS AG

发明人： QIU, Yongxing ,  PRUITT, John Dallas ,  NELSON, Jared

IPC分类号： G02B1/04 ,  B29D11/00

摘要： The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

摘要翻译： 本发明通常涉及包含非硅酮水凝胶镜片主体和其上的水凝胶涂层的软性隐形眼镜。 非硅酮水凝胶镜片主体由不含有机硅的水凝胶材料组成并且包含至少50摩尔％的至少一种含羟基乙烯基单体的重复单元。 水凝胶涂层包含具有第一反应性官能团的第一聚合物材料和衍生自具有第二反应性官能团的第二聚合物材料的水凝胶层，并且水凝胶层通过各自形成于一个第一反应性官能团 和一个第二反应性官能团。 软性隐形眼镜具有比非硅酮水凝胶镜体的润滑性更好的表面润滑性，并且在7次手动摩擦循环后具有约2或更低的摩擦等级，水含量为约10％至约85％ 当在室温下完全水合时，其重量和弹性模量为约0.2MPa至约1.5MPa。

公开(公告)号：WO2014209939A2

公开(公告)日：2014-12-31

申请号：PCT/US2014/043772

申请日：2014-06-24

申请人： NOVARTIS AG ,  TUCKER, Robert Carey ,  PRUITT, John Dallas ,  MUYA, Leroy Wainaina

发明人： TUCKER, Robert Carey ,  PRUITT, John Dallas ,  MUYA, Leroy Wainaina

IPC分类号： A61L12/08

CPC分类号： A61L12/122 ,  C11D3/0078 ,  C11D3/166 ,  C11D3/2079 ,  C11D7/08 ,  C11D7/10 ,  C11D7/265

摘要： The present invention provides an aqueous lens care solution for disinfecting and/or cleaning contact lenses in an ozone-based lens care system. The lens care solution of the invention is a hypotonic solution, has an osmolality at about 25C of from about 200 mOsm/kg to about 260mOsm/kg, and comprises at least one relatively-ozone-inert buffering agent selected from the group consisting of boric acid, sodium tetraborate, potassium tetraborate, acetic acid, sodium acetate, potassium acetate, and a mixture thereof. The aqueous lens care solution is compatible with ozone electrolytically generated in an ozone-based lens care system as characterized by comprising about 30 mM or less of chloride ion and less than about 10 mM of one or more ozone-interfering buffering agents.

摘要翻译： 本发明提供一种用于在基于臭氧的镜片护理系统中消毒和/或清洁隐形眼镜的水性透镜护理液。 本发明的晶状体护理溶液是低渗溶液，约25℃的重量摩尔渗透压浓度为约200mOsm / kg至约260mOsm / kg，并且包含至少一种相对臭氧惰性的缓冲剂，其选自硼酸 酸，四硼酸钠，四硼酸钾，乙酸，乙酸钠，乙酸钾及其混合物。 水性透镜护理溶液与基于臭氧的透镜护理系统中电解产生的臭氧相兼容，其特征在于包含约30mM或更少的氯离子和小于约10mM的一种或多种臭氧干扰缓冲剂。

公开(公告)号：WO2019116142A1

公开(公告)日：2019-06-20

申请号：PCT/IB2018/059474

申请日：2018-11-29

申请人： NOVARTIS AG

发明人： QIU, Yongxing ,  MINICK, Kasey Jon ,  PRUITT, John Dallas ,  SAMUEL, Newton T. ,  CHIANG, Chung-Yuan ,  TALLAU, Kelly Kayi ,  MCCOLLUM, Matthew ,  GOVAN, Richard

IPC分类号： G02B1/04

摘要： A process for producing watr gradient contact lenses comprises a step of staging and heating a contact lens precursor having an anchor layer of a polyanionic polymer in an aqueous solution comprising at least one low molecular weight polyaziridine compound and at least one thermally-crosslinkable hydrophilic polymeric material to form an outer surface hydrogel layer which is covalently attached to the anchor layer, to convert a majority or most negatively-charged groups in the water gradient contact lens into non-charged ester groups through aziridine groups to minimize or eliminate uptake of a polycationic antimicrobial, and to crosslinked the anchor layer through a polyaziridine compound as a flexible crosslinker so as to enforce the durability of the outer surface hydrogel layer while having no or minimal adverse impacts on the wettability, hydrophilicity, and lubricity of the outer surface hydrogel layer on the contact lens.

公开(公告)号：WO2019116140A1

公开(公告)日：2019-06-20

申请号：PCT/IB2018/059472

申请日：2018-11-29

申请人： NOVARTIS AG

发明人： QIU, Yongxing ,  PRUITT, John Dallas ,  SAMUEL, Newton T.

IPC分类号： G02B1/04

摘要： The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime. This process comprises a step of treating a preformed water gradient contact lens with a thick outer surface hydrogel layer thereon with a small, flexible, hydrophilic charge neutralizer, so as to convert a majority or most negatively-charged groups in the water gradient contact lens into non-charged ester groups while enforcing the durability of the outer surface hydrogel layer on the contact lens by crosslinking the anchor layer with a flexible crosslinker and having no or minimal adverse impacts on the wettability, hydrophilicity, and lubricity of the outer surface hydrogel layer on the contact lens.