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公开(公告)号：WO2020194282A1
公开(公告)日：2020-10-01
申请号：PCT/IB2020/053981
申请日：2020-04-28
摘要： The present invention describes pulsed release caffeine formulations comprising caffeine particulate systems prepared by using release retarding agents and at least one or more food grade excipients. The present invention also relates to the process for preparation of caffeine formulations, wherein plurality of particulate systems combined to get the pulsed release caffeine formulation comprising release retarding agents, which provide caffeine release in pulses at different physiological conditions. The pulsed release caffeine formulation is prepared as tablets, capsules, soft gel capsules, caplets, oil suspensions or mixed with nutrient supplements for administration to the subjects. Caffeine formulations as described herein release the caffeine over entire GIT in pulses in a period of 2 to 8 hours and can be administered to subjects for boosting energy, improving concentration, cardiovascular health and for weight management.
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2.发明申请
公开(公告)号：WO2021074763A1
公开(公告)日：2021-04-22
申请号：PCT/IB2020/059534
申请日：2020-10-10
发明人： T. K., Sunil Kumar , NALAWADE, Pravin , LAL, Jangir Mohan , MORDE, Abhijeet , THAKARE, Ravindra
IPC分类号： A61K31/047
摘要： The present invention relates to a xanthophyll composition comprising selective isomers of trans-R,R lutein and trans-R,R zeaxanthin in preferred particle size and pharmaceutically and/or nutraceutically acceptable excipients such as carriers, solubility enhancers, bioavailability enhancing agents, antioxidants and optionally flavoring agents with selective ratio which exerts enhanced bioavailability. The xanthophyll composition at least 80% of total xanthophyll comprised of at least 65% by weight of trans-R,R lutein and at least 10 % by weight of trans-R,R zeaxanthin, which is prepared combinedly from marigold and paprika oleoresins with definite proportion to produce the preferred ratio of trans-R,R lutein and trans-R,R zeaxanthin.
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3.发明申请
公开(公告)号：WO2015173603A1
公开(公告)日：2015-11-19
申请号：PCT/IB2014/001734
申请日：2014-09-04
CPC分类号： A61K9/146 , A23L5/00 , A23L33/10 , A23L33/115 , A23L33/125 , A23L33/15 , A23P10/30 , A61K9/14 , A61K9/5036 , A61K9/5078 , A61K9/5089 , A61K31/047 , A61K31/05 , A61K31/065 , A61K31/12 , A61K31/122 , A61K31/165 , A61K45/06 , A61K2300/00
摘要： The instant invention provides hydrophilic matrix beadlet compositions that include at least one fat soluble nutrient and an effective amount of cellulose polymer with low viscosity. The invention also provides a process for the preparation of the hydrophilic matrix composition by employing a fluid bed system or extrusion spheronization technique. This hydrophilic matrix beadlet composition is comprised of at least 5% to about 25% carotenoid wherein free lutein is present in combination with zeaxanthin. The free flowing nature of the composition allows it to be compressed into tablets or to be filled into two piece capsules or blended as a dry premix for beverage applications. These hydrophilic matrix compositions exhibit desired dissolution characteristics and at least 1.6 times more bioavailability as compared with marketed reference formulations containing modified starch, thus making it advantageous for nutraceutical applications.
摘要翻译： 本发明提供亲水性基质珠粒组合物，其包括至少一种脂溶性营养物和有效量的低粘度的纤维素聚合物。 本发明还提供了一种通过使用流化床系统或挤出滚圆技术制备亲水基质组合物的方法。 该亲水性基质珠粒组合物由至少5％至约25％的类胡萝卜素组成，其中游离叶黄素与玉米黄质组合存在。 组合物的自由流动性质允许其被压缩成片剂或填充成两片胶囊或作为用于饮料应用的干燥预混物共混。 与含有改性淀粉的市售参考制剂相比，这些亲水性基质组合物表现出所需的溶解特性和至少1.6倍的生物利用度，因此使其有利于营养药物应用。
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4.发明申请COMPOSITION OF OILY, PUNGENT AND ODORIFEROUS SUBSTANCES AND A PROCESS OF PREPARATION THEREOF 审中-公开油，ENT ENT US US US OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2015114399A1
公开(公告)日：2015-08-06
申请号：PCT/IB2014/001569
申请日：2014-08-19
发明人： DESHPANDE, Jayant , ACHLIYA, Girish , NALAWADE, Pravin , BHANUSE, Prakash , KHAMBORKAR, Swapnil
CPC分类号： A61K36/81 , A23L2/52 , A23L2/56 , A23L2/58 , A23L5/00 , A23L27/10 , A23L27/16 , A23L27/18 , A23L27/72 , A23L29/262 , A23L29/30 , A23L29/37 , A23L33/105 , A23L33/125 , A23P10/30 , A23V2002/00 , A61K9/1652 , A61K9/1694 , A61K31/165 , A23V2200/21 , A23V2200/224 , A23V2200/332
摘要： A composition of oily, pungent and odoriferous substances and a process for preparation thereof are described, in particular an extended and sustained release of a stable, free flowing, solid composition of one or more of substances such as capsicum, black pepper, ginger, mustard, cinnamon, garlic, onion, paprika, turmeric and the like, extracts thereof, and/or components thereof, and a process for preparation thereof are described. For example, compositions comprise a substance such as capsicum containing capsaicinoid components, which include for example capsaicin, dihydro-capsaicin, and/or nor-dihydro-capsaicin.The composition can eliminate the discomfort by facilitating intestinal absorption of the active ingredient and thereby minimizing/eliminating the discomfort caused by the residual unabsorbed active ingredient, and can be particularly suitable for formulating into consumable dry syrups, tablets, capsules, liquid syrups, health drinks, diet drinks, fruit juices, and/or soft drinks, which can be useful in reduction of body weight.
摘要翻译： 描述了油性，刺鼻和有气味物质的组合物及其制备方法，特别是延长和持续释放一种或多种物质如辣椒，黑胡椒，姜，芥末的稳定的自由流动的固体组合物 ，肉桂，大蒜，洋葱，辣椒粉，姜黄等，其提取物和/或其成分及其制备方法。 例如，组合物包含诸如辣椒素的辣椒素成分的物质，其包括例如辣椒素，二氢辣椒素和/或去氢二氢辣椒素。组合物可以通过促进活性成分的肠吸收并由此最小化而消除不适 /消除残留未吸收的活性成分引起的不适，并且可以特别适用于配制成消耗性干糖浆，片剂，胶囊，液体糖浆，保健饮料，饮食饮料，果汁和/或软饮料，其可以是有用的 减轻体重。
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