公开(公告)号：WO2018022620A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043732

申请日：2017-07-25

Applicant: QORVO US, INC. ,  BELL, Florian ,  MURDOCK, Bruce

Inventor： BELL, Florian ,  MURDOCK, Bruce

IPC: G01N21/00 ,  G01N7/00 ,  G01N30/96

CPC classification number: G01N33/86 ,  B01L3/502715 ,  B01L2300/023 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0436 ,  G01N11/10 ,  G01N11/16 ,  G01N15/0637 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N30/96 ,  G01N33/4905 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2203/0089 ,  G01N2203/0092 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/106

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

Abstract translation: 采用体声波（BAW）谐振器的传感器被用于分析血液的特征。 BAW传感器可以用于感测包含血液的样本的粘度以确定血液的凝结特性。 可以在抑制凝血或促进凝血的药剂存在下评估血液的粘度。 样品在这些试剂存在下的粘度变化可以提供关于血液是否患有凝血障碍的信息。

公开(公告)号：WO2018022757A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043958

申请日：2017-07-26

Applicant: QORVO US, INC. ,  BELL, Florian ,  MORTON, Rick ,  EDWARDS, Thayne L. ,  RYDER, Matthew ,  MURDOCK, Bruce ,  RANDLE, William, Crawford ,  ROMBACH, Cody, William ,  BARTON, Donna, Kay

Inventor： BELL, Florian ,  MORTON, Rick ,  EDWARDS, Thayne L. ,  RYDER, Matthew ,  MURDOCK, Bruce ,  RANDLE, William, Crawford ,  ROMBACH, Cody, William ,  BARTON, Donna, Kay

IPC: H01L41/00 ,  G01F1/68 ,  H02N2/00

CPC classification number: G01N30/96 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/326 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2291/101 ,  H03H9/02102

Abstract: A device including at least one sensing bulk acoustic wave (BAW) resonator including a sensing surface; a fluid channel, wherein the sensing surface of the at least one sensing BAW resonator is disposed adjacent to or within the fluid channel; at least one resistive heater; and at least one temperature detector, wherein the at least one temperature detector is configured to monitor the temperature adjacent to the at least one BAW resonator and affect a current to be passed through the at least one resistive heater.

Abstract translation: 包括至少一个感测体声波（BAW）谐振器的装置，所述感测体声波谐振器包括感测表面; 流体通道，其中所述至少一个感测BAW谐振器的所述感测表面布置成邻近所述流体通道或在所述流体通道内; 至少一个电阻加热器; 以及至少一个温度检测器，其中所述至少一个温度检测器被配置为监测与所述至少一个体声波谐振器相邻的温度并且影响要通过所述至少一个电阻加热器的电流。

公开(公告)号：WO2018026970A1

公开(公告)日：2018-02-08

申请号：PCT/US2017/045184

申请日：2017-08-02

Applicant: QORVO US, INC.

Inventor： EDWARDS, Thayne L. ,  BELL, Florian

IPC: C12M1/34 ,  A61B50/00 ,  F16K31/06

CPC classification number: A61B50/00 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0064 ,  A61B10/007 ,  A61B2010/0067 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0684 ,  B01L2300/0663 ,  B01L2300/0672 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0487

Abstract: A sampler for acquiring and transporting sample material may include a sampler body defining a sampling volume configured to hold the sample material. The sampler body may define a sample port that may be used as an entrance to collect the sample material and an exit to expel the sample material. The sample port may be configured to be operably connected to a fluidic channel of a cartridge. The sampler may also define a pump connection port configured to be operably connected to a pump. The pump may force the sample material out of the sampling volume through the sample port.

Abstract translation: 用于采集和运输样本材料的采样器可以包括采样器本体，该采样器本体限定被配置为保持样本材料的采样体积。 采样器主体可以限定样品端口，该样品端口可以用作收集样品材料的入口和排出样品材料的出口。 样品端口可以被配置为可操作地连接到盒的流体通道。 采样器还可以限定配置成可操作地连接到泵的泵连接端口。 泵可能会迫使样品材料通过样品端口离开采样体积。

公开(公告)号：WO2018022778A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043992

申请日：2017-07-26

Applicant: QORVO US, INC.

Inventor： EDWARDS, Thayne, L. ,  BELL, Florian ,  RYDER, Matthew ,  MURDOCK, Bruce

IPC: G01N29/02 ,  G01N27/00 ,  G01N29/036 ,  G01N29/22 ,  G01N33/543 ,  H03H9/17

CPC classification number: G01N29/022 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0688 ,  B01L2400/088 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/222 ,  G01N29/2437 ,  G01N29/32 ,  G01N2291/014 ,  G01N2291/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2291/106 ,  H03H9/175

Abstract: A cartridge for sample handling and sensing includes a sample port connected to a sample reservoir having a proximal end, a proximal region adjacent the proximal end, and a distal end opposite of the proximal end. The cartridge also includes a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and a second fluid port connected to the sample reservoir in the proximal region via a second fluid channel. In addition, the cartridge includes a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator. The cartridge further includes a fluid valve between the distal end of the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.

Abstract translation: 用于样品处理和感测的盒包括连接到样品池的样品端口，该样品池具有近端，邻近近端的近端区域以及与近端相对的远端。 所述盒还包括第一流体端口，所述第一流体端口经由第一流体通道连接至所述远侧区域中的所述样本容器 以及第二流体端口，其经由第二流体通道连接到近端区域中的样本容器。 另外，所述盒包括传感器平台，所述传感器平台包括体声波（BAW）谐振器和流体流动路径，所述流体流动路径包括跨所述BAW谐振器的传感表面延伸的传感区域。 盒还包括在样品容器的远端和感测区域之间的流体阀。 样本可以应用到样本端口; 第一体积的流体可以通过第一流体端口注入; 然后可以通过第二流体端口注入第二体积的流体以将样本驱动到流体流动路径的感测区域中。