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1.发明申请
公开(公告)号：WO2009049284A3
公开(公告)日：2009-12-30
申请号：PCT/US2008079695
申请日：2008-10-13
Applicant: SIGMA ALDRICH CO , ZHANG MIN , ROSS JAMES S
Inventor： ZHANG MIN , ROSS JAMES S
IPC: C12P21/04 , C12N15/113 , C12P21/06
CPC classification number: C12N15/1137 , C12N9/2402 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2510/02 , C12Y302/01018
Abstract: The present invention provides compositions and methods for the production of glycoproteins with enhanced sialylation. In particular, the invention provides cell lines comprising disrupted sialidase expression and methods of using the cell lines to produce glycoproteins with enhanced sialylation.
Abstract translation: 本发明提供了用于生产具有增强的唾液酸化作用的糖蛋白的组合物和方法。 特别地，本发明提供了包含破坏的唾液酸酶表达的细胞系以及使用该细胞系产生具有增强的唾液酸化作用的糖蛋白的方法。
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2.发明申请
公开(公告)号：WO2012129749A8
公开(公告)日：2013-01-17
申请号：PCT/CN2011001923
申请日：2011-11-18
Applicant: LIAONING ELECTRIC POWER CO LTD , NORTHEAST POWER SCIENT RES INSTITUTION LTD , TONG GANG , LENG JIE , ZHANG MIN , DENG NAN , MA SHENGJIANG , ZHANG YE
IPC: G01F1/34
CPC classification number: G01F1/363
Abstract: Disclosed is an air volume calculation system for a variable speed or constant speed fan, comprising a central processing control system, an upper processing system, a moving vane angle indication transmitter (3) of the fan, an entrance pressure transmitter (14) of the fan, an entrance air temperature transmitter (15) of the fan, an exit pressure transmitter (16) of the fan, a motor current transformer (17) of the fan and a DCS control system (11) of the fan; wherein the moving vane angle indication transmitter (3) of the fan, the entrance pressure transmitter (14) of the fan, the entrance air temperature transmitter (15) of the fan, the exit pressure transmitter (16) of the fan and the motor current transformer (17) of the fan are separately connected to the signal input end of the central processing control system; and the signal input end of the central processing control system is connected to the DCS control system (11) of the fan. The system can decrease the installation complexity of the air volume measurement device, reduce the resistance loss caused by the air volume measurement device, reduce the air volume measurement error, increase the reliability of safe running and add an online air volume characteristic monitoring function.
Abstract translation: 公开了一种用于变速或恒速风扇的风量计算系统，包括中央处理控制系统，上处理系统，风扇的移动叶片角度指示变送器（3），入口压力变送器（14） 风扇，风扇的入口空气温度变送器（15），风扇的出口压力变送器（16），风扇的电动机电流互感器（17）和风扇的DCS控制系统（11）; 其中风扇的移动叶片角度指示发射器（3），风扇的入口压力变送器（14），风扇的入口空气温度变送器（15），风扇的出口压力变送器（16）和电动机 风扇的电流互感器（17）分别连接到中央处理控制系统的信号输入端; 并且中央处理控制系统的信号输入端连接到风扇的DCS控制系统（11）。 该系统可以降低风量测量装置的安装复杂性，降低风量测量装置引起的阻力损失，减少风量测量误差，提高安全运行的可靠性，增加在线风量特征监测功能。
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3.发明申请XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A3
公开(公告)日：2009-01-29
申请号：PCT/US2007020950
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Abstract: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
Abstract translation: 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。
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公开(公告)号：WO2007149458A3
公开(公告)日：2008-11-13
申请号：PCT/US2007014317
申请日：2007-06-20
Applicant: NIELSEN MEDIA RES INC , ZHANG MIN , WRIGHT DAVID HOWELL , COOPER SCOTT , DYKSTRA REGINA , RAMASWAMY ARUN , NELSON DANIEL
Inventor： ZHANG MIN , WRIGHT DAVID HOWELL , COOPER SCOTT , DYKSTRA REGINA , RAMASWAMY ARUN , NELSON DANIEL
CPC classification number: H04N7/163 , G06K9/3266 , G11B27/28 , H04N21/44008 , H04N21/44204 , H04N21/47
Abstract: Methods and apparatus for detecting on-screen media sources are disclosed. An example method includes monitoring a region of interest of a video signal for a first image, comparing the first image to a stored image, and confirming the media device change when the stored image differs from the first image and is associated with a secondary criterion.
Abstract translation: 公开了用于检测屏幕上媒体源的方法和装置。 示例性方法包括监视第一图像的视频信号的感兴趣区域，将第一图像与存储的图像进行比较，以及当存储的图像与第一图像不同并且与次要标准相关联时，确认媒体设备改变。
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5.发明申请ETHANOL PRODUCTION USING XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS 审中-公开用木糖醇合成突变型木糖醇突变株生产乙醇
公开(公告)号：WO2008051348A3
公开(公告)日：2008-09-12
申请号：PCT/US2007020945
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
Abstract: Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
Abstract translation: 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的利用木糖的发酵单胞菌菌株生产乙醇，由于木糖醇的产生大大降低，木糖醇是发酵期间合成的木糖代谢的有害副产物，所以发现其得到改善。
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Patent Agency Ranking6.发明申请MICRO FLOW CYTOMETER WITH MULTIANGULAR WAVEGUIDE DETECTORS HAVING SPECTRAL CAPABILITIES 审中-公开具有光谱能力的多波长检波器的微流量计
公开(公告)号：WO2005033654A3
公开(公告)日：2006-02-16
申请号：PCT/US2004028175
申请日：2004-08-30
Applicant: UNIV MICHIGAN , TUNG YI-CHUNG , LIN CHIH-TING , KURABAYASHI KATSUO , SKERLOS STEVEN J , ZHANG MIN
Inventor： TUNG YI-CHUNG , LIN CHIH-TING , KURABAYASHI KATSUO , SKERLOS STEVEN J , ZHANG MIN
CPC classification number: G01N15/1436 , G01N15/1484
Abstract: A micro flow cytometer having the ability to distinguish light emanating from a particle in the interrogation zone (6) of the cytometer contains a plurality of optical waveguides (10, 11, 12, 13) for receiving emanating light, the optical waveguides (10, 11, 12, 13) positioned at different angles from the axis of the interrogation zone and in the same plane. Photodetectors measuring emanated light provide an electrical signal which is processable to reveal an angular dependence of wavelength with respect to the interrogation channel (6).
Abstract translation: 具有区分在血细胞计数器的询问区（6）中发射的光的能力的微流式细胞计数器包含用于接收发射光的多个光波导（10,11,12,13），光波导（10， 11,12,13），其位于与询问区的轴线不同的角度并位于同一平面内。 测量发射光的光电检测器提供电信号，其可以处理以显示相对于询问通道（6）的波长的角度依赖性。
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公开(公告)号：WO2009120730A3
公开(公告)日：2009-12-10
申请号：PCT/US2009038158
申请日：2009-03-25
Applicant: DU PONT , ALLIANCE SUSTAINABLE ENERGY , VIITANEN PAUL V , TAO LUAN , ZHANG YUYING , CAIMI PERRY G , MCCUTCHEN CAROL , MCCOLE LAURA , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
Inventor： VIITANEN PAUL V , TAO LUAN , ZHANG YUYING , CAIMI PERRY G , MCCUTCHEN CAROL , MCCOLE LAURA , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
IPC: C12N15/09
CPC classification number: C12N15/74
Abstract: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
Abstract translation: 鉴定为运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因的启动子的突变体，其直接改善可操作地连接的异源核酸的表达水平。 这些是用于在发酵单胞菌，酵母属和其他相关细菌中表达嵌合基因的高表达启动子。
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公开(公告)号：WO2009120731A3
公开(公告)日：2009-11-12
申请号：PCT/US2009038164
申请日：2009-03-25
Applicant: DU PONT , ALLIANCE SUSTAINABLE ENERGY , VIITANEN PAUL V , TAO LUAN , ZHANG YUYING , CAIMI PERRY G , MCCUTCHEN CAROL , MCCOLE LAURA , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
Inventor： VIITANEN PAUL V , TAO LUAN , ZHANG YUYING , CAIMI PERRY G , MCCUTCHEN CAROL , MCCOLE LAURA , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
CPC classification number: C12N9/92 , C12N9/0008 , C12N9/1022 , C12N9/1205 , C12P7/065 , Y02E50/17
Abstract: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
Abstract translation: 通过引入含有运动发酵单胞菌甘油醛-3-磷酸脱氢酶基因突变启动子的嵌合木糖异构酶基因来改造发酵单胞菌菌株。 该启动子指导木糖异构酶表达的增加，并且当该菌株另外工程化用于表达木酮糖激酶，转醛醇酶和转酮醇酶时，获得改进的木糖利用。
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9.发明申请PROCESS FOR THE PRODUCTION OF ETHANOL FROM A MEDIUM COMPRISING XYLOSE, EMPLOYING A RECOMBINANT ZYMOMONAS STRAIN HAVING A REDUCED HIMA EXPRESSION 审中-公开从包含XYLOSE的中间产生乙醇的方法，使用具有还原性HIMA表达的重组ZYMOMONASAS菌株
公开(公告)号：WO2009058938A3
公开(公告)日：2009-06-18
申请号：PCT/US2008081694
申请日：2008-10-30
Applicant: DU PONT , VIITANEN PAUL V , TAO LUAN , KNOKE KYLE , ZHANG YUYING , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
Inventor： VIITANEN PAUL V , TAO LUAN , KNOKE KYLE , ZHANG YUYING , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
IPC: C12P7/06
Abstract: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of thehimA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in mixed-sugars medium comprising xylose, and, in particular, in the presence of acetate.
Abstract translation: 通过筛选发酵单胞菌突变文库，发现himA基因参与乙酸盐对发酵单胞菌性能的抑制作用。 当与含有木糖的混合糖培养基，特别是在乙酸存在下培养时，与亲本菌株相比，进一步工程改造以降低himA基因活性的木糖酶发酵单胞菌菌株发现乙醇产量增加。
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10.发明申请XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A2
公开(公告)日：2008-11-06
申请号：PCT/US2007020950
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Abstract: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
Abstract translation: 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。
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