公开(公告)号：WO2014059012A1

公开(公告)日：2014-04-17

申请号：PCT/US2013/064121

申请日：2013-10-09

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： KINNEY, Shawn ,  WEIKART, Christopher ,  HUNT, Benjamin ,  RAICHE, Adrian ,  FITZPATRICK, Brian ,  SAGONA, Peter J. ,  STEVENSON, Adam ,  FELTS, John T. ,  FISK, Thomas E.

IPC: C23C16/04 ,  C23C16/40 ,  C23C16/50 ,  C08J7/00

CPC classification number: C23C16/50 ,  A61J1/065 ,  A61M2205/0238 ,  A61M2207/00 ,  A61M2209/06 ,  C23C16/045 ,  C23C16/401

Abstract: A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, a dispensing portion, and a shield. The shield is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the shield. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication between the barrel lumen and the dispensing portion lumen via the proximal opening at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

Abstract translation: 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括筒体，分配部分和护罩的封盖预组件的筒体的内壁的至少一部分上。 屏蔽件被固定到筒体上，并且至少基本上将分配部分的远端开口与屏蔽外部的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在有效地通过在施加步骤结束时的近端开口保持筒内腔和分配部分内腔之间的连通的条件下施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。