公开(公告)号：WO2016074061A1

公开(公告)日：2016-05-19

申请号：PCT/CA2014/051080

申请日：2014-11-10

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  YUWARAJ, Murugathas ,  KERINS, Fergal

Inventor： PIRON, Cameron ,  YUWARAJ, Murugathas ,  KERINS, Fergal

IPC: G09B23/30 ,  B29C39/12 ,  G09B9/00

CPC classification number: G09B23/34 ,  B29C39/02 ,  B29C39/12 ,  B29C45/1418 ,  B29L2031/40 ,  G09B23/286

Abstract: The present disclosure discloses anatomical phantoms having one or more distinct regions spectroscopically differentiated from each other by inclusion of spectroscopically active components each having a distinct fluorescence/emission/scattering spectrum. The distinct regions may represent different anatomical components of the corresponding real anatomical part and/or tumor mimics (or other diseased tissue) and different anatomical components of the corresponding real anatomical part, or just tumor mimics and a remainder of the anatomical part. The spectroscopically active materials may be dyes such as the cyanine dyes, or spectroscopically active nanoparticles.

Abstract translation: 本公开公开了具有通过包含各自具有不同的荧光/发射/散射光谱的光谱活性成分彼此光谱分化的一个或多个不同区域的解剖体模体。 不同的区域可以表示对应的真实解剖部分和/或肿瘤模拟物（或其他患病组织）和相应的真实解剖部分的不同解剖部件的不同解剖组件，或仅仅是肿瘤模拟物和解剖部件的其余部分。 光谱活性材料可以是染料，例如花青染料或光谱活性纳米颗粒。

公开(公告)号：WO2014139023A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/050271

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  WOOD, Michael ,  SELA, Gal ,  RICHMOND, Joshua ,  YUWARAJ, Murugathas ,  MCFADYEN, Stephen ,  PANTHER, Alex ,  SHANMUGARATNAM, Nishanthan ,  LAU, William ,  THOMAS, Monroe, M. ,  HODGES, Wes ,  ALEXANDER, Simon ,  GALLOP, David

Inventor： PIRON, Cameron ,  WOOD, Michael ,  SELA, Gal ,  RICHMOND, Joshua ,  YUWARAJ, Murugathas ,  MCFADYEN, Stephen ,  PANTHER, Alex ,  SHANMUGARATNAM, Nishanthan ,  LAU, William ,  THOMAS, Monroe, M. ,  HODGES, Wes ,  ALEXANDER, Simon ,  GALLOP, David

IPC: A61B19/00 ,  A61B5/00 ,  B25J13/00 ,  B25J9/18

CPC classification number: A61B17/3421 ,  A61B34/20 ,  A61B34/30 ,  A61B2017/00203 ,  A61B2017/00207 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/3735 ,  A61B2090/3983 ,  A61B2090/504 ,  G05B2219/45123

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract translation: 提供了系统和方法，用于自适应地和互操作地配置在医疗过程中使用的自动化臂。 自动化臂被配置成将自动化臂上的末端执行器定位和定向到目标的期望的距离和取向。 末端执行器可以是外部视频范围，并且目标可以是手术端口。 末端执行器和目标的位置和方位可以不断更新。 可以根据用户命令将臂的位置移动到新的位置。 自动臂可以包括附接到加权框架的多关节臂。 加权帧可以包括塔和支撑梁。

公开(公告)号：WO2014138914A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/000245

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  PANTHER, Alex ,  LUCIANI, Vincent ,  HARRIS, Chad Tyler

Inventor： PIRON, Cameron ,  PANTHER, Alex ,  LUCIANI, Vincent ,  HARRIS, Chad Tyler

IPC: G01R33/565

CPC classification number: G01R33/34046 ,  G01R33/34007 ,  G01R33/34084 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/365 ,  G01R33/385 ,  G01R33/4818 ,  G01R33/482 ,  G01R33/546 ,  G01R33/5608 ,  G01R33/565

Abstract: A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.

Abstract translation: 提供了一种在磁共振成像（MRI）系统中进行数据采集的方法。 系统接收图像的原始数据的至少一部分，并且检测接收的原始数据的部分中的异常。 当检测到异常时，系统可以动态地纠正这些异常，而不需要等待新的扫描。 系统可以在检测到异常时或扫描期间的某个时刻尝试扫描原始数据的违规部分。 该系统还可以使用基于预期值的数字校正方法来校正异常。 可以基于来自阈值，掩模和期望值的变化来检测异常，所有这些都可以使用正在进行的扫描，先前执行的扫描之一和与所执行的扫描类型有关的先验信息来获得。

公开(公告)号：WO2016082017A1

公开(公告)日：2016-06-02

申请号：PCT/CA2014/000849

申请日：2014-11-27

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  YUWARAJ, Murugathas

Inventor： PIRON, Cameron ,  YUWARAJ, Murugathas

IPC: A61B19/00 ,  A61B5/00 ,  A61B6/00 ,  G06T7/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13

CPC classification number: G06T7/0012 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B6/032 ,  A61B6/5247 ,  A61B8/06 ,  A61B8/12 ,  A61B8/485 ,  A61B8/5223 ,  A61B8/5261 ,  A61B34/10 ,  A61B34/20 ,  A61B2034/2055 ,  A61B2090/365 ,  A61B2090/3735 ,  A61B2505/05 ,  G06T7/33 ,  G06T2207/10076 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/30016 ,  G06T2207/30101 ,  G09B23/30

Abstract: A method in a computing device for quantitative surgical image registration includes: prior to a surgical procedure, obtaining, using a first imaging modality, a preoperative image of patient tissue and a plurality of preoperative measurements of a material property of the patient tissue. The preoperative measurements correspond to respective points in the preoperative image. The method includes storing the preoperative image and the preoperative measurements, and during the surgical procedure, using a second imaging modality, capturing an intraoperative image of the patient tissue and a second plurality of intraoperative measurements of the material property of the patient tissue. The intraoperative measurements correspond to respective points in the intraoperative image. The method includes comparing the first and second pluralities of measurements to determine a transformation for registering the preoperative image and the intraoperative image; and storing the transformation in association with one of the intraoperative image and the preoperative image.

Abstract translation: 用于定量外科手术图像配准的计算装置中的方法包括：在外科手术之前，使用第一成像模式获得患者组织的术前图像和对患者组织的材料性质的多次术前测量。 术前测量对应于术前图像中的各个点。 该方法包括：存储术前图像和术前测量，以及在外科手术期间，使用第二成像模态，捕获患者组织的术中图像以及第二多次术中测量患者组织的材料性质。 术中测量对应于术中图像中的各个点。 该方法包括比较第一和第二多个测量以确定用于登记术前图像和术中图像的变换; 并且与所述术中图像和所述术前图像之一相关联地存储所述变换。

公开(公告)号：WO2015135056A1

公开(公告)日：2015-09-17

申请号：PCT/CA2014/050873

申请日：2014-09-15

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  HODGES, Wes ,  PYO, Norman ,  PIRON, Cameron ,  DYER, Kelly

Inventor： HODGES, Wes ,  PYO, Norman ,  PIRON, Cameron ,  DYER, Kelly

IPC: A61B19/00 ,  A61B5/00 ,  A61B6/00 ,  G06F19/00

CPC classification number: G16H50/50 ,  A61B5/0035 ,  A61B5/0042 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/064 ,  A61B5/743 ,  A61B90/37 ,  A61B2034/2055 ,  A61B2090/363 ,  A61B2576/026 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481

Abstract: Methods and systems for providing treatment planning information for a neurology procedure, including neurosurgical procedures. A database containing historical data about historical procedures is accessed. Historical data relevant to a neurology procedure is determined, based on a determination of similarity to a set of data characterizing the neurology procedure. Historical instances of procedure parameters relevant to the neurology procedure are determined and displayed.

Abstract translation: 提供神经外科手术治疗计划信息的方法和系统，包括神经外科手术。 可以访问包含有关历史过程的历史数据的数据库。 基于与表征神经学程序的一组数据的相似性的确定来确定与神经病学程序相关的历史数据。 确定和显示与神经病学程序相关的程序参数的历史实例。

公开(公告)号：WO2014139022A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/050270

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  WOOD, Michael ,  SELA, Gal ,  RICHMOND, Joshua ,  YUWARAJ, Murugathas ,  THOMAS, Monroe M. ,  HODGES, Wes ,  ALEXANDER, Simon ,  GALLOP, David ,  PANTHER, Alex ,  SHANMUGARATNAM, Nishanthan ,  LAU, William

Inventor： PIRON, Cameron ,  WOOD, Michael ,  SELA, Gal ,  RICHMOND, Joshua ,  YUWARAJ, Murugathas ,  THOMAS, Monroe M. ,  HODGES, Wes ,  ALEXANDER, Simon ,  GALLOP, David ,  PANTHER, Alex ,  SHANMUGARATNAM, Nishanthan ,  LAU, William

IPC: A61B19/00 ,  A61B1/05 ,  A61B5/055 ,  A61B5/06

CPC classification number: A61B5/065 ,  A61B5/0042 ,  A61B5/0095 ,  A61B5/055 ,  A61B5/14539 ,  A61B17/3421 ,  A61B34/20 ,  A61B90/50 ,  A61B90/90 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2053 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2090/103 ,  A61B2090/365 ,  A61B2090/3735 ,  A61B2090/3762 ,  A61B2090/3782 ,  A61B2090/3983 ,  A61B2090/571 ,  A61B2562/0247 ,  A61N1/0534

Abstract: Disclosed herein is navigation and simulation systems and methods for minimally invasive therapy in which the navigation system imports a planning method using patient specific pre-operative images. The navigation system uses intraoperative imaging during the medical procedure to update the preoperative images and provides images of tracked surgical tools along the surgical path prepared from the preoperative images.

Abstract translation: 这里公开了用于微创治疗的导航和模拟系统和方法，其中导航系统使用患者特定的手术前图像来导入计划方法。 导航系统在医疗过程中使用术中成像来更新术前图像，并根据术前图像准备的手术路径提供跟踪的外科手术工具的图像。

公开(公告)号：WO2014139021A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/050269

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  SELA, Gal ,  THOMAS, Monroe M. ,  ALEXANDER, Simon ,  YUWARAJ, Murugathas ,  WOOD, Michael ,  PANTHER, Alex ,  RICHMOND, Joshua ,  HODGES, Wes ,  GALLOP, David

Inventor： PIRON, Cameron ,  SELA, Gal ,  THOMAS, Monroe M. ,  ALEXANDER, Simon ,  YUWARAJ, Murugathas ,  WOOD, Michael ,  PANTHER, Alex ,  RICHMOND, Joshua ,  HODGES, Wes ,  GALLOP, David

IPC: A61B19/00 ,  A61B5/00 ,  A61B6/00 ,  G06F19/00

CPC classification number: A61B34/10 ,  A61B5/0075 ,  A61B5/7246 ,  A61B17/3421 ,  A61B34/20 ,  A61B34/25 ,  A61B90/50 ,  A61B2034/101 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/252 ,  A61B2034/256 ,  A61B2090/103 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2090/571 ,  A61B2576/026 ,  G06F19/00 ,  G06F19/321 ,  G06F19/325 ,  G06F19/3481 ,  G06T7/0014 ,  G06T7/30 ,  G06T2207/30016 ,  G16H10/40 ,  G16H10/60 ,  G16H50/20 ,  G16H50/70

Abstract: Systems and methods are provided in which local tissue diagnostic measurements are correlated with archival local tissue diagnostic data from prior tissue analyses to supplement diagnostic measurements with tissue analysis data from prior tissue analyses having similar local tissue diagnostic data. The tissue analysis data may include information such as pathology data, outcome data, and diagnosis data. The archived local tissue diagnostic data and the tissue analysis data may be stored in a database, and employed for a wide variety of methods, involving preoperative, intraoperative, and/or postoperative phases of a medical procedure. Methods and systems are also provided for displaying, on a medical image shown in a user interface, hyperlinked reference markers associated with tissue analyses, where the reference markers are shown at locations corresponding to local tissue analyses, and where associated diagnostic data and/or tissue analysis may be viewed by selecting a given reference marker.

Abstract translation: 提供了系统和方法，其中局部组织诊断测量与来自先前组织分析的归档局部组织诊断数据相关，以补充具有相似局部组织诊断数据的来自组织分析数据的组织分析数据。 组织分析数据可以包括诸如病理数据，结果数据和诊断数据的信息。 存档的局部组织诊断数据和组织分析数据可以存储在数据库中，并且用于涉及医疗程序的术前，术中和/或术后阶段的各种各样的方法。 还提供了方法和系统，用于在用户界面中显示的医学图像上显示与组织分析相关联的超链接参考标记，其中在与局部组织分析对应的位置处示出参考标记，并且其中相关联的诊断数据和/或组织 可以通过选择给定的参考标记来观察分析。

公开(公告)号：WO2014138997A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/050243

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  SELA, Gal ,  ALEXANDER, Simon ,  PIRON, Cameron ,  RICHMOND, Joshua ,  WOOD, Michael ,  YUWARAJ, Murugathas ,  GALLOP, David ,  HODGES, Wes ,  THOMAS, Monroe M.

Inventor： SELA, Gal ,  ALEXANDER, Simon ,  PIRON, Cameron ,  RICHMOND, Joshua ,  WOOD, Michael ,  YUWARAJ, Murugathas ,  GALLOP, David ,  HODGES, Wes ,  THOMAS, Monroe M.

IPC: A61B19/00 ,  A61B5/00 ,  G06F19/00 ,  G09B23/28 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13

CPC classification number: G06T7/0012 ,  A61B5/0066 ,  A61B5/055 ,  A61B34/10 ,  A61B90/11 ,  A61B2034/105 ,  G06T2207/30012 ,  G09B23/30

Abstract: Disclosed herein is a method for producing an evolvable tissue model of a patient and, using this model, modelling physical transformations of the tissue (e.g. deformation) of the tissue model by interacting the tissue model with influence models which model interactions with the tissue such as surgical instruments, pressure, swelling, temperature changes etc. The model is produced from a set of input data of the tissue which includes directional information of the tissue. The directional information is used to produce an oriented tissue map. A tissue model is then produced from the oriented tissue map such that the tissue model reflects the directionality of the tissue component. When the tissue model is subjected to an influence that causes tissue deformation over a period of time, the tissue model directionally deforms over the period of time in a manner which reflects a trajectory of the influence interacting with the directionality of the tissue component.

Abstract translation: 本文公开了一种用于产生患者的可演化组织模型的方法，并且使用该模型通过将组织模型与模型与组织相互作用的影响模型相互作用来模拟组织模型的物理变换（例如变形），例如 手术器械，压力，肿胀，温度变化等。该模型由组织的一组输入数据产生，包括组织的方向信息。 方向信息用于产生定向组织图。 然后从定向组织图生成组织模型，使得组织模型反映组织成分的方向性。 当组织模型受到在一段时间内引起组织变形的影响时，组织模型以反映与组织成分的方向性相互作用的影响的轨迹的方式在一段时间内定向变形。

公开(公告)号：WO2014138915A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/000246

申请日：2014-03-14

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC. ,  PIRON, Cameron ,  PANTHER, Alex

Inventor： PIRON, Cameron ,  PANTHER, Alex

IPC: G01R33/34

CPC classification number: G01R33/34046 ,  G01R33/34007 ,  G01R33/34084 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/365 ,  G01R33/385 ,  G01R33/4818 ,  G01R33/482 ,  G01R33/546 ,  G01R33/5608 ,  G01R33/565

Abstract: A magnetic resonance imaging (MRI) system is provided. The system includes a main field magnet generating a main magnetic field B0. Moreover, the system further includes radio frequency (RF) receiver coils including a first combination of two coils, the two coils of the first combination decoupled based on quadrature decoupling such that the two coils of the first combination are able to receive signals orthogonal to each other and to B0. The two coils can be butterfly coils, the loop-plain of the butterfly coils arranged along a surface, the longitudinal axis of the butterfly coils being substantially orthogonal and crossing at substantially midpoint. The surface can be substantially orthogonal to B0 and be curved. The first of the two coils can also be a loop coil and the second of the two coils a butterfly coil.

Abstract translation: 提供磁共振成像（MRI）系统。 该系统包括产生主磁场B0的主磁场磁体。 此外，该系统还包括包括两个线圈的第一组合的射频（RF）接收器线圈，第一组合的两个线圈基于正交解耦去耦，使得第一组合的两个线圈能够接收与每个线圈正交的信号 其他和B0。 两个线圈可以是蝶形线圈，蝶形线圈的环形平面沿着表面布置，蝶形线圈的纵向轴线基本上是正交的并且在大致中点处交叉。 表面可以基本上与B0正交并弯曲。 两个线圈中的第一个也可以是环形线圈，并且两个线圈中的第二个线圈是蝶形线圈。

公开(公告)号：WO2016132176A1

公开(公告)日：2016-08-25

申请号：PCT/IB2015/051285

申请日：2015-02-19

Applicant: SYNAPTIVE MEDICAL (BARBADOS) INC.

Inventor： PIRON, Cameron ,  STAINSBY, Jeff ,  HARRIS, Chad

IPC: A61B5/03 ,  A61B5/055

CPC classification number: A61B5/055 ,  A61B5/031 ,  A61B5/032 ,  A61B5/4058 ,  A61B5/4076 ,  A61B5/4809 ,  A61B2576/00 ,  G01R33/56341 ,  G01R33/56366

Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid ("CSF") using magnetic resonance imaging ("MRI") are described. In general, images are obtained from a subject using flow- sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract translation: 描述了使用磁共振成像（“MRI”）提供脑脊液（“CSF”）的全局血液流量定量测量的系统和方法。 一般来说，使用被设计为对CSF的淋巴管流特别敏感的流敏MRI技术从受试者获得图像。 当受试者处于清醒状态时，并且当受试者处于睡眠状态时，可以获得血液流量的测量。 基于这两个测量，可以产生指示神经系统状态或疾病的生物标志物。