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公开(公告)号：WO02070509A8
公开(公告)日：2003-11-06
申请号：PCT/US0206256
申请日：2002-02-28
发明人： LABORDE EDGARDO , ROBINSON LOUISE , MENG FANYING , PETERSON BRIAN T , VILLAR HUGO O , ANUSKIEWICZ STEVEN E , ISHIWATA YOSHIRO , YOKOCHI SHOJI , MATSUMOTO YUKIHARU , KAKIGAMI TAKUJI , INAGAKI HIDEAKI , JOMORI TAKAHITO , MATSUSHIMA KOUJI
IPC分类号： A61K31/357 , A61K31/41 , A61K31/427 , A61K31/4433 , A61K31/47 , A61K31/498 , A61K31/538 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D215/48 , C07D241/42 , C07D241/44 , C07D265/36 , C07D319/18 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C07D215/48 , C07D241/42 , C07D265/36 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译： 本发明涉及化合物，包含所述化合物的药物组合物，所述化合物和组合物的用途，使用所述化合物和组合物的治疗方法，以及制备所述化合物的方法。 具体而言，本发明涉及作为MCP-1功能的拮抗剂的新化合物，其可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病，例如关节炎，哮喘，动脉粥样硬化， 糖尿病肾病，炎性肠病，克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应。 更具体地，本发明涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗这些疾病中的用途。
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公开(公告)号：WO0044366A2
公开(公告)日：2000-08-03
申请号：PCT/US0002297
申请日：2000-01-27
申请人： TELIK INC
发明人： REDELMEIER THOMAS , KAUVAR LAWRENCE M , LUM ROBERT T , LYTTLE MATTHEW H , MACSATA ROBERT W , SCHOW STEVEN R , VILLAR HUGO O , KOZLOWSKI MICHAEL R
CPC分类号： A61K9/127 , A61K9/1075 , A61K38/063
摘要： Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the stimulatory action of one or a combination of cytokines on colony formation by hematopoietic progenitor cells, protect a subject from a destructive effect of a chemotherapeutic agent or irradiation, or to potentiate the effect of a chemotherapeutic agent.
摘要翻译： 药物组合物及其使用方法。 谷胱甘肽类似物的脂质制剂及其制造方法。 它们用于刺激造血，保护造血细胞免受辐射或化疗引起的损伤，或增强细胞因子对造血祖细胞的集落形成的一种或组合的刺激作用，保护受试者免受化学治疗剂或辐射的破坏作用 ，或增强化学治疗剂的作用。
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公开(公告)号：WO02060900A8
公开(公告)日：2003-11-06
申请号：PCT/US0203016
申请日：2002-01-30
发明人： LABORDE EDGARDO , ROBINSON LOUISE , MENG FANYING , PETERSON BRIAN T , VILLAR HUGO O , ANUSKIEWICZ STEVEN E , ISHIWATA YOSHIRO , YOKOCHI SHOJI , MATSUMOTO YUKIHARU , KAKIGAMI TAKUJI , INAGAKI HIDEAKI , JOMORI TAKAHITO , MATSUSHIMA KOUJI
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/18 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/08 , C07D471/04 , C07D498/04 , C07D519/00 , A61K31/435 , A61K31/495 , A61K31/535 , A61K31/55
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention relates to chemical compounds of Formula (I) or (II) (wherein Y, Z and R - R are defined herein), pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
摘要翻译： 本发明涉及式（I）或（II）的化合物（其中Y，Z和R 1 -R 6在本文中定义），包含所述化合物的药物组合物，所述化合物和组合物的用途，方法 使用所述化合物和组合物的处理，以及制备所述化合物的方法。 具体地说，本发明涉及作为MCP-1功能拮抗剂的新型化合物，可用于预防或治疗慢性或急性炎性或自身免疫性疾病。 更具体地，本发明涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗这些疾病中的用途。
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4.发明申请
公开(公告)号：WO02076930A3
公开(公告)日：2003-01-16
申请号：PCT/US0206217
申请日：2002-03-01
申请人： TELIK INC
发明人： ROBINSON LOUISE , VILLAR HUGO O
IPC分类号： A61P31/00 , A61K31/17 , A61K31/275 , A61P19/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07B57/00 , C07C273/02 , C07C273/16 , C07C275/30 , C07C275/42 , C07C309/65 , C07C317/42
CPC分类号： C07C275/30 , C07C275/42 , C07C309/65 , C07C317/42
摘要： Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them, are useful in methods of treating autoimmune diseases, infectious diseases, and malignancies.
摘要翻译： 取代的二芳基脲，含有它们的药物组合物及其用于刺激Fas介导的凋亡的用途。 化合物作为单立体异构体或立体异构体的混合物，其药学上可接受的盐和含有它们的药物组合物可用于治疗自身免疫性疾病，感染性疾病和恶性肿瘤的方法。
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