公开(公告)号：WO2021102292A1

公开(公告)日：2021-05-27

申请号：PCT/US2020/061555

申请日：2020-11-20

Applicant: THE CHARLES STARK DRAPER LABORATORY INC.

Inventor： TANDON, Vishal ,  KIM, Ernest ,  BORENSTEIN, Jeffrey

IPC: A61F11/00

Abstract: The present disclosure provides a handpiece (100) for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump (1104) and a fluid reservoir (1106). The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.

公开(公告)号：WO2013086011A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/067971

申请日：2012-12-05

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： BORENSTEIN, Jeffrey T. ,  CHAREST, Joseph L. ,  HSIAO, James C. ,  KNIAZEVA, Tatiana ,  KIM, Ernest ,  EPSHTEYN, Alla ,  KOLACHALAMA, Vijaya

IPC: A61M1/16

CPC classification number: A61M1/1698 ,  A61M2206/20

Abstract: A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.

Abstract translation: 本文公开了一种用于血液充氧的装置和方法。 该装置包括多个被动混合元件，其在流过该装置时使流体混合。 被动混合元件将新的红细胞持续暴露于可以发生氧合的流动通道部分。 因此，在一些实施方案中，与常规氧合方法和装置相比，装置和方法使用更少的血液来引发装置，并允许具有相当短的流动通道的血液氧合。

公开(公告)号：WO2021102298A1

公开(公告)日：2021-05-27

申请号：PCT/US2020/061565

申请日：2020-11-20

Applicant: THE CHARLES STARK DRAPER LABORATORY INC.

Inventor： TANDON, Vishal ,  KIM, Ernest ,  BORENSTEIN, Jeffrey

IPC: A61F11/00 ,  A61M5/142 ,  A61B17/34

Abstract: The present solution provides systems and methods for trans-round window membrane drug delivery. As an overview, a system can include a micropump that is connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce the round window membrane of a patient. Using the handpiece, the cannula can be inserted through the round window membrane to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-round window membrane drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.

公开(公告)号：WO2017223193A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/038532

申请日：2017-06-21

Applicant: THE CHARLES STARK DRAPER LABORATORY INC. ,  MASS EYE AND EAR INFIRMARY

Inventor： KIM, Ernest ,  MCKENNA, Michael ,  KIRINGODA, Ruwan

IPC: A61M31/00 ,  A61M5/142

Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.

Abstract translation: 本公开讨论了用于将治疗物质经管道递送至内耳的手持件。 手机可以通过外科鼓室切口入路插入中耳。 手持件可以使治疗物质能够通过圆窗膜直接进入内耳。 将治疗物质直接输送至内耳可以使精确量的治疗物质输送至内耳。 由于治疗性物质直接递送至内耳，治疗性物质的递送不受制于当治疗性物质扩散穿过圆窗膜时分子大小和不一致扩散速率的限制。

公开(公告)号：WO2014039441A1

公开(公告)日：2014-03-13

申请号：PCT/US2013/057842

申请日：2013-09-03

Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.

Inventor： DIBIASIO, Christopher ,  CHAREST, Joseph L. ,  BORENSTEIN, Jeffrey T. ,  KIM, Ernest ,  HARJES, Daniel I.

IPC: A61M1/16 ,  B01D61/24 ,  B01D63/08

CPC classification number: A61M1/34 ,  A61M1/16 ,  A61M1/1631 ,  A61M1/1698 ,  A61M1/3403 ,  A61M1/36 ,  A61M2202/0413 ,  A61M2205/0244 ,  A61M2205/75 ,  B01D61/243 ,  B01D63/005 ,  B01D63/082 ,  B01D63/085 ,  B01D63/088 ,  B01D2313/08 ,  B01D2313/105 ,  B01D2319/04 ,  B01L3/5027 ,  B01L2300/0864 ,  B01L2300/0874 ,  F17D1/00 ,  Y10T137/794

Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.

Abstract translation: 提供了一种用于输送剪切敏感流体的紧凑型液压歧管。 信道网络可以包括耦合到分叉架构的中继线和分支架构。 可以使用诸如锥形通道壁，通道的曲率和通道角度以及低流体压力的区域来减小尺寸，同时将壁剪切速率保持在窄范围内。 液压歧管可以连接到一系列微流体层以构造紧凑的微流体装置。