公开(公告)号：WO1996013247A1

公开(公告)日：1996-05-09

申请号：PCT/US1995014076

申请日：1995-10-30

Applicant: TRISTRATA, INC.

Inventor： TRISTRATA, INC. ,  YU, Ruey, J. ,  VAN SCOTT, Eugene, J.

IPC: A61K07/32

CPC classification number: A61Q15/00 ,  A23L3/3481 ,  A23L3/349 ,  A23L3/3499 ,  A23L3/3508 ,  A23L3/3517 ,  A61K8/34 ,  A61K8/368 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/43 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/92 ,  A61K31/215 ,  A61K31/22 ,  A61K31/222 ,  A61K31/235 ,  A61K31/34 ,  A61K31/415 ,  A61K31/43 ,  A61K31/44 ,  A61K31/495 ,  A61K31/535 ,  A61K31/60 ,  A61K31/70 ,  A61K38/12 ,  A61K2800/524 ,  A61Q1/12 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/008 ,  Y02A50/473 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/859 ,  Y10S514/863 ,  Y10S514/873 ,  A61K31/165 ,  A61K31/135 ,  A61K2300/00

Abstract: Therapeutic treatment as well as propylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of axillary foul odor, foot malodor and other body odors, e.g. scalp, and skin, nail and follicular infections caused by microorganisms. The compositions are antimicrobial against several organisms that infect the skin and are specifically effective against P. acnes. The compositions are therapeutically effective against folliculitis and perifolliculitis and are useful for other skin lesions, nail and mucosal infections such as impetigo, seborrheic dermatitis, erythrasma and thrichomycosis axillaris, associated with or caused by microorganisms. The therapeutic effect of the composition may be synergized or amplified by incorporating a cosmetic or dermatologic agent into the formulation for topical treatment of cosmetic and dermatologic indications. The compositions are also useful as preservatives in food products, cosmetic and pharmaceutical formulations, and industrial preparations.

Abstract translation: 通过局部施用含有2-乙酰氧基乙酸芳基酯的组合物来提供治疗性治疗以及丙烯酸的措施，以消除或预防腋臭，脚臭和其它身体气味的发生，例如， 头皮和皮肤，微生物引起的指甲和滤泡感染。 所述组合物对几种感染皮肤的生物具有抗微生物性，并且对抗痤疮丙酸杆菌特别有效。 所述组合物对于毛囊炎和血管周炎是治疗有效的，并且可用于与微生物相关或由微生物引起的其它皮肤病变，指甲和粘膜感染如脓疱疮，脂溢性皮炎，红斑狼疮和沙眼癣菌。 组合物的治疗效果可以通过将化妆品或皮肤病剂掺入到用于局部治疗化妆品和皮肤病适应症的制剂中来协同或扩增。 该组合物还可用作食品，化妆品和药物制剂以及工业制剂中的防腐剂。