公开(公告)号：WO2020188372A1

公开(公告)日：2020-09-24

申请号：PCT/IB2020/051444

申请日：2020-02-20

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： IKONEN, Timo ,  BOYLAN, Christopher ,  HARJU, Ari ,  HILTUNEN, Petri ,  KAUPPINEN, Juha ,  KOKKONEN, Petri ,  PETAJA, Viljo ,  RUSANEN, Marko T ,  SILJAMAKI, Sami P ,  TORSTI, Tuomas E ,  KUUSELA, Esa ,  KARJALAINEN, Antti

IPC: A61N5/10

Abstract: A method of calculating radiation dose includes dosimetric projection of a collimator geometry. The method includes defining a three-dimensional (3D) geometry of a collimating device which defines an aperture configured to allow a radiation beam passing through, projecting the collimating device along the radiation beam into a two-dimensional (2D) geometry in a plane, calculating dosimetric opacity values of the collimating device at locations adjacent to the aperture based on the 3D geometry of the collimating device, and calculating transport of the radiation beam through the collimating device based on the 2D geometry projected in the plane and using the dosimetric opacity values of the collimating device at the locations adjacent to the aperture.

公开(公告)号：WO2022002822A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/067631

申请日：2021-06-28

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： HIRVONEN, Petri ,  ROSSI, Michiko ,  LANSONNEUR, Pierre ,  ROPO, Matti ,  PETAJA, Viljo ,  NIEMELA, Perttu ,  KOPONEN, Timo

IPC: A61N5/10 ,  A61N2005/1087 ,  A61N5/103 ,  A61N5/1031 ,  G16C20/20 ,  G16H20/40 ,  G16H50/50

Abstract: A crystalline structure modeling methodology that is conventionally used to model crystalline matter down to the atomic level is instead used to determine spot placement for radiation treatment. The cross-sectional shape of a treatment target is specified 202; locations (peaks) in a density field inside the shape are determined using the crystalline structure model 204; locations of spots in the treatment target for spot scanning are determined 206, where the locations correspond to the locations (peaks) inside the shape determined using the crystalline structure model; and the locations of the spots are stored as candidates for potential inclusion in a radiation treatment plan 208.

公开(公告)号：WO2021259977A1

公开(公告)日：2021-12-30

申请号：PCT/EP2021/067101

申请日：2021-06-23

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG ,  VARIAN MEDICAL SYSTEMS, INC. ,  LANSONNEUR, Pierre ,  NIEMELA, Perttu ,  PETAJA, Viljo ,  BUSOLD, Simon ,  ROSSI, Michiko ,  ROPO, Matti Sakari ,  FOLKERTS, Michael ,  PEREZ, Jessica ,  SMITH, Christel ,  HARRINGTON, Adam ,  ABEL, Eric ,  HALKO, Lauri

Inventor： LANSONNEUR, Pierre ,  NIEMELA, Perttu ,  PETAJA, Viljo ,  BUSOLD, Simon ,  ROSSI, Michiko ,  ROPO, Matti Sakari ,  FOLKERTS, Michael ,  PEREZ, Jessica ,  SMITH, Christel ,  HARRINGTON, Adam ,  ABEL, Eric ,  HALKO, Lauri

IPC: A61N5/10 ,  G16H10/60 ,  G16H20/40 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N5/103 ,  A61N5/1038 ,  G16H40/63 ,  G16H50/50

Abstract: A method used for planning radiation treatment accessing (802) information that includes calculated doses and calculated dose rates for sub-volumes in a treatment target, and also accessing (804) information that includes values of a measure of the sub-volumes as a function of the calculated doses and the calculated dose rates. A graphical user interface includes a rendering (806) that is based on the calculated doses, the calculated doses rates, and the values of the measure.

公开(公告)号：WO2018050886A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073441

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: An optimized radiation treatment plan may be developed in which the total monitor unit (MU) count is taken into account, A planner may specify a maximum treatment time. An optimization algorithm may convert the specified maximum treatment time to a maximum total MU count, which is then used as a constraint in the optimization process. A cost function for the optimization algorithm may include a term that penalizes any violation of the upper constraint for the MU count.

Abstract translation: 可以开发优化的放射治疗计划，其中考虑总监测单位（MU）计数，计划者可以指定最大治疗时间。 优化算法可以将指定的最大处理时间转换为最大总MU计数，然后将其用作优化处理中的约束。 优化算法的成本函数可能包含一个惩罚任何违反MU计数上限约束的术语。

公开(公告)号：WO2023275027A1

公开(公告)日：2023-01-05

申请号：PCT/EP2022/067695

申请日：2022-06-28

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO, KG

Inventor： PFEILER, Tina ,  VANDERSTRAETEN, Reynald ,  ROSSI, Michiko ,  HUTH, Isabel ,  PETAJA, Viljo

IPC: A61N5/10 ,  A61N2005/1034 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1071 ,  G21K5/04

Abstract: Presented systems and methods enable efficient and effective robust radiation treatment planning and treatment, including analysis of dose rate robustness. In one embodiment, a method (1900) comprising accessing (1910) treatment plan information, accessing (1920) information corresponding to an uncertainty associated with implementation of the radiation treatment plan, and generating (1930) a histogram, wherein the histogram conveys a characteristic of the treatment plan including an impact of the uncertainty on the characteristic. The histogram can be a dose rate volume histogram (700, 710) and can be utilized to test a degree of robustness of a treatment plan (e.g., including allowance for uncertainty scenarios, etc.). The uncertainty can be associated with potential variation associated with tolerances (e.g., radiation system/machine performance tolerance, patient characteristic tolerances, etc.) and set up issues (e.g., variation in initial system/machine set up, variation patient setup/position, etc.)

公开(公告)号：WO2018050883A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073422

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: In a radiation treatment plan that includes a plurality of treatment fields of multiple treatment modalities, such as IMRT modality and dynamic treatment path modality (e.g., VMAT and conformal arc therapy), an optimized spatial point sequence may be determined that optimizes the total treatment time, which includes both the beam-on time (i.e., during the delivery of radiation dose) and the beam-off time (i.e., during transitions between consecutive treatment fields). The result is a time-ordered field trajectory that intermixes and interleaves different treatment fields, in one embodiment, a dynamic treatment path may be cut into a plurality of sections, and one or more IMRT fields may be inserted between the plurality of sections.

Abstract translation: 在包括诸如IMRT模态和动态治疗路径模态（例如，VMAT和共形电弧治疗）的多个治疗模态的多个治疗场的放射治疗计划中，优化的空间点序列可以 被确定为优化总治疗时间，其包括射束开启时间（即，在辐射剂量的递送期间）和射束关闭时间（即，在连续治疗区域之间的过渡期间）。 结果是混合并交织不同处理区域的时间有序的场轨迹。在一个实施例中，动态处理路径可以被切割成多个区段，并且可以在多个区段之间插入一个或多个IMRT字段。 / p>