公开(公告)号：WO2020136162A1

公开(公告)日：2020-07-02

申请号：PCT/EP2019/086908

申请日：2019-12-23

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, OFFICE OF THE GENERAL COUNSEL

Inventor： LOCKE, Christopher, Barry ,  OLLILA, Santtu ,  BUSH, Karl, Kenneth

IPC: A61N5/10

Abstract: Methods of treatment trajectory optimization for radiotherapy treatment of multiple targets include determining beam's eye view (BEV) regions and a BEV region connectivity manifold for each target group of a plurality of target groups separately. The information contained in the BEV regions and the BEV region connectivity manifolds for all target groups is used to guide an optimizer to find optimal treatment trajectories. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.

公开(公告)号：WO2018104291A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/081492

申请日：2017-12-05

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne

IPC: A61N5/10

Abstract: A method for determining MLC leaf sequences for radiation treatment includes obtaining BEV projections of a first target volume and a second target volume along one or more treatment paths of a radiation treatment plan, analyzing the BEV projections to determine one or more contiguous ranges of spatial points where there exists an interstitial region between the first target volume and the second target volume in the direction of MLC leaf motion, and determining a first set of MLC leaf sequences such that an aperture formed by the MLC in a first portion of the one or more contiguous ranges of spatial points exposes radiation to the first target volume but not the second target volume, and an aperture formed by the MLC in a second portion of the one or more contiguous ranges of spatial points exposes radiation to the second target volume but not the first target volume.

公开(公告)号：WO2020136169A1

公开(公告)日：2020-07-02

申请号：PCT/EP2019/086925

申请日：2019-12-23

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, OFFICE OF THE GENERAL COUNSEL

Inventor： LOCKE, Christopher, Barry ,  OLLILA, Santtu ,  BUSH, Karl, Kenneth

IPC: A61N5/10

Abstract: Methods of beam angle optimization for intensity modulated radiotherapy (1MRT) treatment include determining beam's eye view (BEV) regions and a BEV region connectivity manifold by evaluating dose response of each region of interest for each vertex in a delivery coordinate space (DCS). The information contained in the BEV regions and the BEV region connectivity manifold is used to guide an optimizer to find optimal field geometries in the IMRT treatment. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.

公开(公告)号：WO2018054873A3

公开(公告)日：2018-03-29

申请号：PCT/EP2017/073568

申请日：2017-09-19

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa

IPC: A61N5/10

Abstract: Methods and systems are provided for developing radiation therapy treatment plans. A treatment template with radiation fields can be chosen for a patient based on a tumor location. Static radiation field positions can be adjusted for the patient, while arc radiation fields may remain the same. Static radiation field positions can be adjusted using dose gradient, historical patient data, and other techniques.

Abstract translation: 为开发放射疗法治疗计划提供了方法和系统。 基于肿瘤位置可以为患者选择具有辐射场的治疗模板。 可以为患者调整静态辐射场位置，而电弧辐射场可以保持不变。 可以使用剂量梯度，历史患者数据和其他技术来调整静态辐射场位置。

公开(公告)号：WO2020069421A3

公开(公告)日：2020-04-02

申请号：PCT/US2019/053623

申请日：2019-09-27

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  VARIAN MEDICAL SYSTEMS, INC.

Inventor： OLLILA, Santtu ,  WAREING, Todd Arlin ,  MCGHEE, John Morton ,  BARNETT, JR., Douglas Allen ,  MASLOWSKI, Alexander Enrique

IPC: A61N5/10

Abstract: A method of trajectory optimization for radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining one or more optimal treatment trajectories based on the BEV region connectivity manifold.

公开(公告)号：WO2018054873A2

公开(公告)日：2018-03-29

申请号：PCT/EP2017/073568

申请日：2017-09-19

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa

IPC: A61N5/10

Abstract: Methods and systems are provided for developing radiation therapy treatment plans. A treatment template with radiation fields can be chosen for a patient based on a tumor location. Static radiation field positions can be adjusted for the patient, while arc radiation fields may remain the same. Static radiation field positions can be adjusted using dose gradient, historical patient data, and other techniques.

公开(公告)号：WO2018050883A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073422

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: In a radiation treatment plan that includes a plurality of treatment fields of multiple treatment modalities, such as IMRT modality and dynamic treatment path modality (e.g., VMAT and conformal arc therapy), an optimized spatial point sequence may be determined that optimizes the total treatment time, which includes both the beam-on time (i.e., during the delivery of radiation dose) and the beam-off time (i.e., during transitions between consecutive treatment fields). The result is a time-ordered field trajectory that intermixes and interleaves different treatment fields, in one embodiment, a dynamic treatment path may be cut into a plurality of sections, and one or more IMRT fields may be inserted between the plurality of sections.

Abstract translation: 在包括诸如IMRT模态和动态治疗路径模态（例如，VMAT和共形电弧治疗）的多个治疗模态的多个治疗场的放射治疗计划中，优化的空间点序列可以 被确定为优化总治疗时间，其包括射束开启时间（即，在辐射剂量的递送期间）和射束关闭时间（即，在连续治疗区域之间的过渡期间）。 结果是混合并交织不同处理区域的时间有序的场轨迹。在一个实施例中，动态处理路径可以被切割成多个区段，并且可以在多个区段之间插入一个或多个IMRT字段。 / p>

公开(公告)号：WO2020069421A2

公开(公告)日：2020-04-02

申请号：PCT/US2019/053623

申请日：2019-09-27

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG ,  VARIAN MEDICAL SYSTEMS, INC.

Inventor： OLLILA, Santtu ,  WAREING, Todd Arlin ,  MCGHEE, John Morton ,  BARNETT, JR., Douglas Allen ,  MASLOWSKI, Alexander Enrique

IPC: A61N5/10

Abstract: A method of trajectory optimization for radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs), defining a delivery coordinate space (DCS), for each ROI, solving an adjoint transport to obtain an adjoint solution field from the ROI, for each vertex in the DCS, evaluating an adjoint photon fluence by performing ray tracing of the adjoint solution field, evaluating a dose of the ROI using the adjoint photon fluence, for each vertex in the DCS, evaluating a respective beam's eye view (BEV) score of each pixel of a BEV plane using the doses of the one or more ROIs, determining one or more BEV regions in the BEV plane based on the BEV scores, determining a BEV region connectivity manifold based on the BEV regions, and determining one or more optimal treatment trajectories based on the BEV region connectivity manifold.

公开(公告)号：WO2018054907A1

公开(公告)日：2018-03-29

申请号：PCT/EP2017/073652

申请日：2017-09-19

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne

IPC: A61N5/10

Abstract: Streamlined and partially automated methods of setting normal tissue objectives in radiation treatment planning are provided. These methods may be applied to multiple-target cases as well as single-target cases. The methods can impose one or more target-specific dose falloff constraints around each target, taking into account geometric characteristics of each target such as target volume and shape. In some embodiments, methods can also take into account a planner's preferences for target dose homogeneity. In some embodiments, methods can generate additional dose falloff constraints in locations between two targets where dose bridging is likely to occur.

Abstract translation: 提供了在放射治疗计划中设定正常组织目标的简化和部分自动化的方法。 这些方法可能适用于多目标案例以及单目标案例。 考虑到每个目标的几何特征，诸如目标体积和形状，该方法可以在每个目标周围施加一个或多个目标特定剂量衰减约束。 在一些实施例中，方法还可以考虑计划者对目标剂量均匀性的偏好。 在一些实施方案中，方法可以在可能发生剂量桥接的两个目标之间的位置产生额外的剂量衰减约束。

公开(公告)号：WO2018050886A1

公开(公告)日：2018-03-22

申请号：PCT/EP2017/073441

申请日：2017-09-18

Applicant: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG

Inventor： OLLILA, Santtu ,  VAINIO, Mikko ,  PELTOLA, Jarkko ,  NORD, Janne ,  KUUSELA, Esa ,  KAUPPINEN, Juha ,  PETAJA, Viljo ,  RUSANEN, Marko

IPC: A61N5/10

Abstract: An optimized radiation treatment plan may be developed in which the total monitor unit (MU) count is taken into account, A planner may specify a maximum treatment time. An optimization algorithm may convert the specified maximum treatment time to a maximum total MU count, which is then used as a constraint in the optimization process. A cost function for the optimization algorithm may include a term that penalizes any violation of the upper constraint for the MU count.

Abstract translation: 可以开发优化的放射治疗计划，其中考虑总监测单位（MU）计数，计划者可以指定最大治疗时间。 优化算法可以将指定的最大处理时间转换为最大总MU计数，然后将其用作优化处理中的约束。 优化算法的成本函数可能包含一个惩罚任何违反MU计数上限约束的术语。