-
公开(公告)号：WO2019154795A1
公开(公告)日：2019-08-15
申请号：PCT/EP2019/052751
申请日：2019-02-05
发明人： VANDENABEELE, Peter , VANDEN BERGHE, Tom , AUGUSTYNS, Koen , HOFMANS, Sam , VAN DER VEKEN, Pieter , DEVISSCHER, Lars
IPC分类号： C07C311/38 , C07D295/14 , C07D295/12 , C07D213/38 , A61K31/18 , A61K31/495 , A61K31/5375 , A61P9/10 , A61P3/10 , A61P37/06 , A61P25/28 , A61P25/16
摘要： The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.
-
2.发明申请
公开(公告)号：WO2016075330A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076680
申请日：2015-11-16
发明人： VANDENABEELE, Peter , VANDEN BERGHE, Tom , AUGUSTYNS, Koen , JOOSSENS, Jurgen , VAN DER VEKEN, Pieter , HOFMANS, Sam
IPC分类号： C07D239/26 , C07C311/39 , C07C311/40 , C07D295/26 , C07D213/38 , A61K31/18 , A61K31/4409 , A61K31/495 , A61K31/535 , A61P25/28
CPC分类号： C07C311/39 , C07C311/40 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/38 , C07D239/26 , C07D295/26
摘要： The present invention relates to a novel class of compounds having the structure of formula (I) and pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. These compounds inhibit or reduce the non-apoptotic cell death forms ferroptosis and/or oxytosis rendering them useful for the treatment of various conditions disclosed herein.
摘要翻译： 本发明涉及具有式（I）结构的新一类化合物和包含式（I）化合物或其药学上可接受的盐的药物组合物。 这些化合物抑制或减少非凋亡细胞死亡形式的铁锈和/或催产，使得它们可用于治疗本文公开的各种病症。
-
公开(公告)号：WO2008025830A2
公开(公告)日：2008-03-06
申请号：PCT/EP2007/059069
申请日：2007-08-30
CPC分类号： A61K38/4873 , A61K8/66 , A61Q17/02 , A61Q17/04
摘要： The present invention relates to the field of sunscreen compositions for preventing or treating the harmful effects of solar radiation in skin. More particularly the invention provides sunscreen compositions comprising caspase-14 as an ingredient.
摘要翻译： 本发明涉及用于预防或治疗太阳辐射对皮肤的有害影响的防晒组合物领域。 更具体地，本发明提供了包含半胱天冬酶-14作为成分的防晒组合物。
-
公开(公告)号：WO2005025591A2
公开(公告)日：2005-03-24
申请号：PCT/EP2004/010597
申请日：2004-09-17
IPC分类号： A61K38/00
CPC分类号： C12Q1/37 , A61K38/4873 , C12Q1/485
摘要： The present invention relates to caspase derived caspase recruitment domains (CARDs). More specifically, the invention relates to CARDs derived from procaspase-1 and procaspase-2, and their use to induce nuclear factor of the Κ-enhancer in B-cells (NF-ΚB) activation and/or p38 MAP kinase activation.
摘要翻译： 本发明涉及半胱天冬酶衍生的半胱天冬酶募集域（CARD）。 更具体地说，本发明涉及来源于procaspase-1和procaspase-2的CARD，以及它们在B细胞（NF-κB）激活和/或p38MAP激酶活化中诱导κ-增强子的核因子的用途。 p>
-
公开(公告)号：WO2015140313A1
公开(公告)日：2015-09-24
申请号：PCT/EP2015/055975
申请日：2015-03-20
申请人： VIB VZW , UNIVERSITEIT GENT
CPC分类号： A61K38/45 , C12N9/1205 , G01N2500/02
摘要： The present invention relates to a 4-helical bundle domain fragment (4HBD) of mixed-lineage kinase domain-like (MLKL) that is necessary and sufficient to induce necroptosis in cells, by binding to phosphatidylinositol phosphates (PIPs). The invention relates further to the use of this domain to screen inhibitors of the MLKL-PIP binding, and the use of those inhibitors to prevent necroptosis and to treat necroptosis associated diseases.
摘要翻译： 本发明涉及通过结合磷脂酰肌醇磷酸酯（PIP）而必需和足以诱导细胞中的棘皮动物的混合谱系激酶结构域（MLKL）的4-螺旋形束状结构域片段（4HBD）。 本发明进一步涉及该结构域用于筛选MLKL-PIP结合的抑制剂的用途，以及这些抑制剂用于预防人工坏死和用于治疗棘球根动物相关疾病的用途。
-
6.发明申请TARGETING OF INTERLEUKIN-1 AND -18 SIGNALING IN TREATMENT OF SEPTIC SHOCK 审中-公开白细胞介素-1和-18信号治疗分离性休克的指标
公开(公告)号：WO2015110346A1
公开(公告)日：2015-07-30
申请号：PCT/EP2015/050679
申请日：2015-01-15
申请人： VIB VZW , UNIVERSITEIT GENT
IPC分类号： A61K38/17 , A61K39/395 , A61P31/00
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/507 , C07K16/244 , C07K16/2866 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to the inactivation of interleukin-1 and interleukin-18 signaling in treatment of inflammation and septic shock. More specifically, it relates to a sequential or simultaneous application of both an interleukin-1 receptor antagonist and an interleukin-18 antibody. In one preferred embodiment, a combination treatment of an IL-1 receptor antagonist and an IL-18 antibody is used.
摘要翻译： 本发明涉及白细胞介素-1和白细胞介素-18信号在治疗炎症和败血性休克中的失活。 更具体地，本发明涉及白细胞介素-1受体拮抗剂和白细胞介素-18抗体的顺序或同时应用。 在一个优选实施方案中，使用IL-1受体拮抗剂和IL-18抗体的组合治疗。
-
7.发明申请
公开(公告)号：WO2005118632A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052401
申请日：2005-05-25
IPC分类号： C07K14/47
CPC分类号： C07K14/4702
摘要： The present invention relates to a novel member of the card protein family. More specifically, it relates to a novel human card-only protein. The invention relates further to the use of this protein to inhibit pro-interleukin-1β maturation, preferably without inducing NF- K B activity or apoptosis.
摘要翻译： 本发明涉及卡蛋白家族的新成员。 更具体地说，它涉及一种新颖的仅用于人卡的蛋白质。 本发明进一步涉及这种蛋白质用于抑制前白介素-1β成熟，优选不诱导NF-κB活性或细胞凋亡的用途。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.016 秒)
