公开(公告)号：WO2012106524A3

公开(公告)日：2013-02-28

申请号：PCT/US2012023645

申请日：2012-02-02

Applicant: GENOMIND LLC ,  LOMBARD JAY L

Inventor： LOMBARD JAY L

IPC: A61K31/65 ,  A61K31/165 ,  A61K31/166 ,  A61K31/185 ,  A61K31/19 ,  A61P25/00

CPC classification number: A61K31/00 ,  A23L33/12 ,  A23L33/16 ,  A23L33/175 ,  A23V2002/00 ,  A61B5/055 ,  A61B5/4088 ,  A61K31/19 ,  A61K31/198 ,  A61K31/201 ,  A61K31/202 ,  A61K31/65 ,  A61K33/00 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2800/302 ,  G01N2800/50 ,  G01N2800/52 ,  G01R33/56341 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/0616 ,  A23V2250/1604 ,  A23V2250/186

Abstract: Described herein are compounds (including medical foods, pharmaceutical compositions, methods of compounding them), methods and systems for the diagnosis and/or treatment of prodromal schizophrenia. For example, described herein are methods of treating a developmentally-based neuropsychiatric disorder (schizophrenia) that includes first determining if a subject is at risk for such a disorder by examining phenotypical, serological immune markers and genotypical biomarkers. The biomarkers may be used to tailor the dose to be delivered by the medial food or pharmaceutical composition. Also described are compounds for treating prodromal (rather than full-blown) schizophrenia.

Abstract translation: 本文描述的是化合物（包括医疗食品，药物组合物，复合方法），用于诊断和/或治疗前驱性精神分裂症的方法和系统。 例如，本文描述的是治疗基于发育的神经精神障碍（精神分裂症）的方法，其包括首先通过检查表型，血清学免疫标记和基因型生物标志物来确定受试者是否处于这种疾病的风险中。 生物标志物可用于定制由内侧食物或药物组合物递送的剂量。 还描述了用于治疗前驱（而不是全身）精神分裂症的化合物。

公开(公告)号：WO2011117333A2

公开(公告)日：2011-09-29

申请号：PCT/EP2011/054511

申请日：2011-03-24

Applicant: MEDESIS PHARMA ,  MAUREL, Jean-Claude

Inventor： MAUREL, Jean-Claude

CPC classification number: A61K31/28 ,  A23L33/16 ,  A23P10/35 ,  A23V2002/00 ,  A61K9/1075 ,  A23V2200/306 ,  A23V2200/322 ,  A23V2200/328 ,  A23V2250/1604 ,  A23V2250/1612 ,  A23V2250/1632 ,  A23V2250/1636

Abstract: The present invention relates to reverse micelle system based on sterols, acylglycerols, phospholipids or sphingo lipids and metal ions. Reverse micelle system of the invention is able to cross mucosa and cellular membranes. It thus allows vectorization of metal ions to target sites. It is advantageously useful in the pharmaceutical and dietetic fields.

Abstract translation: 本发明涉及基于甾醇，酰基甘油，磷脂或鞘磷脂和金属离子的反胶束体系。 本发明的反胶束系统能够穿过粘膜和细胞膜。 因此，它允许将金属离子向量化到靶位点。 它有利于药物和饮食领域。

公开(公告)号：WO02076436A3

公开(公告)日：2003-03-13

申请号：PCT/NL0200197

申请日：2002-03-27

Applicant: MEIJER JAAP

Inventor： MEIJER JAAP

IPC: A23L1/29 ,  A23L1/302 ,  A23L1/304 ,  A23L1/303

CPC classification number: A23L33/16 ,  A23L33/15 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/334 ,  A23V2250/1598 ,  A23V2250/1604 ,  A23V2250/1608 ,  A23V2250/1626 ,  A23V2250/1632 ,  A23V2250/1636 ,  A23V2250/708 ,  A23V2250/704 ,  A23V2250/70 ,  A23V2250/2116 ,  A23V2250/314 ,  A23V2250/026 ,  A23V2250/156 ,  A23V2250/702 ,  A23V2250/7106 ,  A23V2250/712 ,  A23V2250/7142 ,  A23V2250/0644

Abstract: The invention pertains to a dietary supplement composition, comprising at least two compositions A and B which are to be taken at different points in time, wherein composition A consists essentially of water soluble vitamins and composition B consists essentially of fat soluble vitamins. Composition A is an energy-rich composition, comprised of water soluble vitamins, supplemented with further ingredients and minerals, which is taken in the morning and preferably immediately after breakfast. Composition B is a composition for recovery of the cells in the rest phase (i.e. during the night), comprised of fat soluble vitamins, supplemended with other ingredients and minerals, which is taken in the evening and preferably immediately after dinner. Composition A comprises as vitamins predominantly vitamin C, vitamin B-1, vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H, and composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1.

Abstract translation: 本发明涉及膳食补充剂组合物，其包含将在不同时间点摄取的至少两种组合物A和B，其中组合物A基本上由水溶性维生素组成，组合物B基本上由脂溶性维生素组成。 组合物A是能量丰富的组合物，由水溶性维生素组成，补充有进一步的成分和矿物质，其在早晨被摄取，并且优选在早餐后立即被摄取。 组合物B是用于回收余下阶段（即夜间）中的细胞的组合物，其由在晚上摄取的脂肪可溶性维生素组成，优选在晚餐后立即摄取。 组合物A主要包含维生素C，维生素B-1，维生素B-2，维生素B-3，维生素B-5，维生素B-6，维生素B-12，维生素B-15和维生素H的维生素和组合物 B主要包含维生素A，维生素A，维生素C，维生素D3和维生素K1。

公开(公告)号：WO2002076436A2

公开(公告)日：2002-10-03

申请号：PCT/NL2002/000197

申请日：2002-03-27

Applicant: MEIJER, Jaap

Inventor： MEIJER, Jaap

IPC: A61K31/00

CPC classification number: A23L33/16 ,  A23L33/15 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/334 ,  A23V2250/1598 ,  A23V2250/1604 ,  A23V2250/1608 ,  A23V2250/1626 ,  A23V2250/1632 ,  A23V2250/1636 ,  A23V2250/708 ,  A23V2250/704 ,  A23V2250/70 ,  A23V2250/2116 ,  A23V2250/314 ,  A23V2250/026 ,  A23V2250/156 ,  A23V2250/702 ,  A23V2250/7106 ,  A23V2250/712 ,  A23V2250/7142 ,  A23V2250/0644

Abstract: The invention pertains to a dietary supplement composition, comprising at least two compositions A and B which are to be taken at different points in time, wherein composition A consists essentially of water soluble vitamins and composition B consists essentially of fat soluble vitamins. Composition A is an energy-rich composition, comprised of water soluble vitamins, supplemented with further ingredients and minerals, which is taken in the morning and preferably immediately after breakfast. Composition B is a composition for recovery of the cells in the rest phase (i.e. during the night), comprised of fat soluble vitamins, supplemended with other ingredients and minerals, which is taken in the evening and preferably immediately after dinner. Composition A comprises as vitamins predominantly vitamin C, vitamin B-1, vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H, and composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1.

Abstract translation: 本发明涉及膳食补充剂组合物，其包含将在不同时间点摄取的至少两种组合物A和B，其中组合物A基本上由水溶性维生素组成，组合物B基本上由脂溶性维生素组成。 组合物A是能量丰富的组合物，由水溶性维生素组成，补充有进一步的成分和矿物质，其在早晨被摄取，并且优选在早餐后立即被摄取。 组合物B是用于回收余下阶段（即夜间）中的细胞的组合物，其由在晚上摄取的脂肪可溶性维生素组成，优选在晚餐后立即摄取。 组合物A主要包含维生素C，维生素B-1，维生素B-2，维生素B-3，维生素B-5，维生素B-6，维生素B-12，维生素B-15和维生素H的维生素和组合物 B主要包含维生素A，维生素A，维生素C，维生素D3和维生素K1。

公开(公告)号：WO2017151723A1

公开(公告)日：2017-09-08

申请号：PCT/US2017/020125

申请日：2017-03-01

Applicant: NOVA SOUTHEASTERN UNIVERSITY

Inventor： RAWAS-QALAJI, Mutasem ,  DETH, Richard

IPC: A61K31/714 ,  A23L1/302 ,  C01D15/00

CPC classification number: A61K31/714 ,  A23L33/00 ,  A23L33/15 ,  A23L33/16 ,  A23V2002/00 ,  A61K9/006 ,  A61K31/122 ,  A61K31/519 ,  A61K33/00 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/1604 ,  A23V2250/706

Abstract: The invention provides methods and cobalamin (vitamin B 12 ) nutraceutical compositions for improving cognitive function in subjects suffering from disorders of cognitive function such as neurodegenerative disorders, neurodevelopmental disorders, and neuropsychiatry disorders. This improvement in cognitive function is achieved through the ability of the cobalamin (vitamin B 12 ) nutraceutical compositions to increase methylation capacity and vitamin B 12 activity the brain of the subjects.

Abstract translation: 本发明提供用于改善患有认知功能障碍如神经退行性障碍，神经发育障碍和神经精神病的受试者的认知功能的方法和维生素B12（维生素B12）营养制品组合物 障碍。 这种认知功能的改善是通过钴胺素（维生素B12）营养制品组合物增加受试者大脑的甲基化能力和维生素B12活性的能力来实现的。 / p>

公开(公告)号：WO2012106524A2

公开(公告)日：2012-08-09

申请号：PCT/US2012/023645

申请日：2012-02-02

Applicant: GENOMIND, LLC ,  LOMBARD, Jay, L.

Inventor： LOMBARD, Jay, L.

IPC: A61K31/65 ,  A61K31/166 ,  A61K31/165 ,  A61K31/19 ,  A61K31/185 ,  A61P25/00

CPC classification number: A61K31/00 ,  A23L33/12 ,  A23L33/16 ,  A23L33/175 ,  A23V2002/00 ,  A61B5/055 ,  A61B5/4088 ,  A61K31/19 ,  A61K31/198 ,  A61K31/201 ,  A61K31/202 ,  A61K31/65 ,  A61K33/00 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2800/302 ,  G01N2800/50 ,  G01N2800/52 ,  G01R33/56341 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/0616 ,  A23V2250/1604 ,  A23V2250/186

Abstract: Described herein are compounds (including medical foods, pharmaceutical compositions, methods of compounding them), methods and systems for the diagnosis and/or treatment of prodromal schizophrenia. For example, described herein are methods of treating a developmentally-based neuropsychiatric disorder (schizophrenia) that includes first determining if a subject is at risk for such a disorder by examining phenotypical, serological immune markers and genotypical biomarkers. The biomarkers may be used to tailor the dose to be delivered by the medial food or pharmaceutical composition. Also described are compounds for treating prodromal (rather than full-blown) schizophrenia.

Abstract translation: 本文描述的是化合物（包括医疗食品，药物组合物，复合方法），用于诊断和/或治疗前驱性精神分裂症的方法和系统。 例如，本文描述的是治疗基于发育的神经精神障碍（精神分裂症）的方法，其包括首先通过检查表型，血清学免疫标记和基因型生物标志物来确定受试者是否处于这种疾病的风险中。 生物标志物可用于定制由内侧食物或药物组合物递送的剂量。 还描述了用于治疗前驱（而不是全身）精神分裂症的化合物。

公开(公告)号：WO2011117333A3

公开(公告)日：2012-06-07

申请号：PCT/EP2011054511

申请日：2011-03-24

Applicant: MEDESIS PHARMA ,  MAUREL JEAN-CLAUDE

Inventor： MAUREL JEAN-CLAUDE

IPC: A61K47/48 ,  A23L1/30 ,  A61K9/107 ,  A61K31/28

CPC classification number: A61K31/28 ,  A23L33/16 ,  A23P10/35 ,  A23V2002/00 ,  A61K9/1075 ,  A23V2200/306 ,  A23V2200/322 ,  A23V2200/328 ,  A23V2250/1604 ,  A23V2250/1612 ,  A23V2250/1632 ,  A23V2250/1636

Abstract: The present invention relates to reverse micelle system based on sterols, acylglycerols, phospholipids or sphingo lipids and metal ions. Reverse micelle system of the invention is able to cross mucosa and cellular membranes. It thus allows vectorization of metal ions to target sites. It is advantageously useful in the pharmaceutical and dietetic fields.

Abstract translation: 本发明涉及基于甾醇，酰基甘油，磷脂或鞘磷脂和金属离子的反胶束体系。 本发明的反胶束系统能够穿过粘膜和细胞膜。 因此，它允许将金属离子向量化到靶位点。 它有利于药物和饮食领域。

公开(公告)号：WO2007044638A1

公开(公告)日：2007-04-19

申请号：PCT/US2006/039335

申请日：2006-10-06

Applicant: McNEIL NUTRITIONALS, LLC ,  AIMUTIS, William, Ronald, Jr. ,  CATANI, Steven, J. ,  PAESCHKE, Teresa, Marie ,  TRACY, Timothy, E.

Inventor： AIMUTIS, William, Ronald, Jr. ,  CATANI, Steven, J. ,  PAESCHKE, Teresa, Marie ,  TRACY, Timothy, E.

IPC: A23L1/0524 ,  A23L1/0532 ,  A23L1/29 ,  A23L1/308 ,  A21D13/08

CPC classification number: A23L33/30 ,  A23L29/231 ,  A23L29/256 ,  A23L29/272 ,  A23V2002/00 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2250/1604 ,  A23V2250/1614 ,  A23V2250/16 ,  A23V2250/5026 ,  A23V2250/5054 ,  A23V2250/5072 ,  A23V2250/50722

Abstract: Compositions and methods for reducing weight, improving weight loss and for providing satiety are provided. Such compositions include at least one soluble anionic fiber and at least one monovalent cation.

Abstract translation: 提供了减轻体重，改善体重减轻和提供饱腹感的组合物和方法。 这种组合物包括至少一种可溶性阴离子纤维和至少一种一价阳离子。