公开(公告)号：WO2016169718A1

公开(公告)日：2016-10-27

申请号：PCT/EP2016/056369

申请日：2016-03-23

Applicant: CAREBAY EUROPE LTD

Inventor： MAXFIELD, Brian

IPC: A61M5/20 ,  A61M5/24

CPC classification number: A61M5/31585 ,  A61M5/2033 ,  A61M5/3202 ,  A61M2005/2013 ,  A61M2005/2477 ,  A61M2207/00

Abstract: The present invention relates to a automatic injection device comprising an elongated housing (10) extending in a longitudinal direction, which housing (10) is arranged to accommodate a medicament container (16), an end cap (52) arranged with a first attachment element (98, 100) designed to engage with a second attachment element (102) on said housing for attaching said end cap (52) to said housing (10), a rotator (62) rotatably arranged inside said housing (10), an activator (32) axially slidable with respect to the housing from an extended position to a retracted position and operably connected to said rotator (62) such as to rotate said rotator (62) from an initial non-activated rotational position and an activated rotational position when the activator (32) is moved from the extended to the retracted position, said rotator (62) further comprises a blocking element (76) arranged to cooperate with said first attachment element (98, 100) for preventing disengagement of said first attachment element (98, 100) from said second attachment element (102) when the rotator (62) is in the activated rotational position.

Abstract translation: 本发明涉及一种自动注射装置，其包括沿纵向方向延伸的细长壳体（10），所述壳体（10）布置成容纳药物容器（16），端盖（52）布置有第一附接元件 （98,100），设计成与所述壳体上的第二附接元件（102）接合，用于将所述端盖（52）附接到所述壳体（10）;可旋转地布置在所述壳体（10）内的旋转器（62） （32），其可相对于所述壳体从延伸位置轴向滑动到缩回位置并且可操作地连接到所述旋转器（62），以便使所述旋转体（62）从初始未激活的旋转位置和激活的旋转位置旋转， 所述活化器（32）从所述延伸位置移动到所述缩回位置，所述旋转器（62）还包括阻挡元件（76），所述阻挡元件布置成与所述第一附接元件（98,100）配合，以防止所述第一粘土 当旋转器（62）处于被激活的旋转位置时，来自所述第二附接元件（102）的铰链元件（98,100）。

公开(公告)号：WO2016134491A1

公开(公告)日：2016-09-01

申请号：PCT/CH2016/000021

申请日：2016-01-28

Applicant: TECPHARMA LICENSING AG

Inventor： HIRSCHEL, Jürg ,  MOSER, Ulrich ,  BURREN, Stefan ,  BOHNER, Reto ,  BIGLER, Bernhard ,  SCHRUL, Christian

IPC: A61M5/24

CPC classification number: A61M5/24 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/2485 ,  A61M2207/00

Abstract: Die Erfindung betrifft einen Karpulenhalter (8) zur Aufnahme einer Karpule (10) und zur Befestigung an eine Antriebs- und/oder an eine Dosiereinrichtung und/oder an einem Gehäuse (6) einer Injektionsvorrichtung mit einem Halteelement (9, 9', 9") zur Befestigung der Karpule (10) an oder in dem Karpulenhalter (8), wobei das Halteelement (9, 9', 9") derart ausgebildet ist, dass es mit dem Karpulenhalter (8) verbindbar ist und von dem Karpulenhalter (8) vollständig aufnehmbar ist.

Abstract translation: 本发明涉及一种安瓿保持件（8），以接收一个安瓿（10）和用于连接到驱动器和/或计量装置上和/或在外壳（6）的保持元件（9,9注射装置”的，9“ ）（对于安瓿10）的附接至或（在安瓿保持件8），其中所述保持元件（9,9”，9“）被设计成使得它连接到安瓿保持件（8）和（的安瓿保持件8） 完全容纳。

公开(公告)号：WO2014008601A1

公开(公告)日：2014-01-16

申请号：PCT/CA2013/050536

申请日：2013-07-10

Applicant: MAGNE, Luc

Inventor： LEE, Ryan ,  DRLIK, Mark

IPC: A61M5/24 ,  A61M5/31 ,  A61M5/50

CPC classification number: A61M5/3202 ,  A61M5/24 ,  A61M5/3243 ,  A61M5/326 ,  A61M5/3293 ,  A61M2005/2414 ,  A61M2005/2477 ,  A61M2005/3128 ,  A61M2005/3247

Abstract: A hydraulically actuated capsule for use with a dental syringe is provided. The capsule has a cover that can reciprocally cover, uncover and re-cover the syringe needle. A piston is urged upward in a cylinder to release a latching mechanism on the cover. As the cover is biased towards the uncovered position, once the latching mechanism is released, the cover will automatically slide proximally. After use, the user slides the cover distally and then removes the capsule. A dental syringe with the capsule is also provided.

Abstract translation: 提供了一种用于牙科注射器的液压致动胶囊。 胶囊具有能够相互覆盖，露出和重新覆盖注射器针的盖。 活塞在气缸中被向上推动以释放盖上的锁定机构。 当盖子朝向未覆盖位置偏置时，一旦闩锁机构被释放，盖子将自动向近侧滑动。 使用后，使用者将护罩向远侧滑动，然后取出胶囊。 还提供了具有胶囊的牙科注射器。

公开(公告)号：WO2012084927A1

公开(公告)日：2012-06-28

申请号：PCT/EP2011/073379

申请日：2011-12-20

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH ,  JUGL, Michael ,  KRAFT, Torsten

Inventor： JUGL, Michael ,  KRAFT, Torsten

IPC: A61M5/24

CPC classification number: A61M5/2459 ,  A61M5/24 ,  A61M5/2455 ,  A61M5/2466 ,  A61M5/28 ,  A61M2005/2477 ,  Y10T29/49826

Abstract: The present invention relates to a cartridge holder assembly for a drug delivery device comprising: a cartridge holder (14) adapted to receive a cartridge (12) filled with a medicament to be dispensed by the drug delivery device, wherein the cartridge holder (14) comprises a first through opening (30) at a distal end section to receive a piercing element (20) adapted to penetrate a sealing member (22) of the cartridge (12); a support structure (40; 42) adjacently arranged to the first through opening (30); and a constriction member (36; 38) arranged between the support structure (40; 42) and a distal end face of the cartridge (12) and having a second through opening (44) smaller than the first through opening (30).

Abstract translation: 本发明涉及一种用于药物输送装置的药筒保持器组件，包括：药筒保持器（14），其适于容纳填充有待由药物输送装置分配的药物的药筒（12），其中药筒保持器（14） 包括在远端部分处的第一通孔（30），用于接收适于穿过所述药筒（12）的密封构件（22）的刺穿元件（20）; 相邻地布置到所述第一通孔（30）的支撑结构（40; 42）; 以及设置在所述支撑结构（40; 42）和所述暗盒（12）的远端面之间并且具有小于所述第一通孔（30）的第二通孔（44）的收缩构件（36; 38）。

公开(公告)号：WO2011081867A2

公开(公告)日：2011-07-07

申请号：PCT/US2010/060022

申请日：2010-12-13

Applicant: SHL GROUP AB ,  GIAMBATTISTA, Lucio ,  BENDEK, Antonio

Inventor： GIAMBATTISTA, Lucio ,  BENDEK, Antonio

IPC: A61M5/315

CPC classification number: A61M5/31551 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31558 ,  A61M5/31561 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/2485 ,  A61M2005/2488 ,  A61M2005/3126 ,  A61M2005/3154

Abstract: The present invention relates to a medicament delivery device comprising a housing having opposite distal and proximal ends; a medicament container holder releasably connected to said housing; a medicament container arranged inside said medicament container holder; a threaded plunger rod arranged to pass through a first inner wall of the housing and arranged to act on a stopper in the medicament container; a lead screw member coaxially connected to the threaded plunger rod by co-acting first slidably-and-rotatably-locked means; wherein said device further comprises a nut coaxially connected to the threaded plunger rod by a treaded engagement between them, connected to the lead screw member by co- acting non-slidable-and-rotatable means, and connected to the housing by co- acting second slidably-and-rotatably-locked means; a primary dose member coaxially rotatable on the lead screw member when the device is in a non- activated state and connected to the lead screw member by co-acting third slidably-and-rotatably-locked means when the device is in an activated state; a locking member fixedly connected to the housing and releasably connected to the lead screw member by co-acting locking means; a first spring force means arranged between the first inner wall of the housing and the nut, wherein the first spring force means is in a pre-tensioned state when said locking means are engaged and the device is in the non-activated state; a secondary dose member rotatably connected to said primary dose member via a pinion gear; dose setting means connected to the primary dose member by co-acting fourth slidably-and- rotatably-locked means, such that when the device is to be set from the non- activated state to the activated state, the dose setting means are manually manipulated in a pre-determined direction, whereby the locking means are released and the lead screw member is distally moved a pre-determined distance by the first spring force means independent of the size of a dose to be set.

Abstract translation: 药物输送装置技术领域本发明涉及一种药物输送装置，其包括具有相对的远端和近端的壳体; 药物容器保持器，其可释放地连接到所述壳体; 布置在所述药物容器保持器内的药物容器; 螺纹柱塞杆，所述螺纹柱塞杆布置成穿过所述壳体的第一内壁并且布置成作用在所述药物容器中的塞子上; 通过共同作用的第一可滑动和旋转锁定装置同轴地连接到螺纹柱塞杆的导螺杆构件; 其中所述装置还包括螺母，所述螺母通过它们之间的螺纹接合而与所述螺纹柱塞杆同轴地连接，所述螺母通过协作的不可滑动和可旋转装置连接到所述导螺杆构件并且通过协作的第二 可滑动和旋转锁定装置; 当所述装置处于非激活状态时，所述主剂量构件可在所述导螺杆构件上同轴地旋转，并且当所述装置处于激活状态时，所述主剂量构件通过协同作用的第三可滑动且旋转锁定装置连接至所述导螺杆构件; 锁定构件，所述锁定构件固定地连接到所述壳体并且通过协作的锁定装置可释放地连接到所述导螺杆构件; 设置在壳体的第一内壁和螺母之间的第一弹簧力装置，其中当所述锁定装置接合并且装置处于非激活状态时，第一弹力装置处于预张紧状态; 经由小齿轮可旋转地连接到所述主剂量构件的次剂量构件; 剂量设定装置通过共同作用的第四可滑动和旋转锁定装置连接到主剂量构件，使得当装置从非激活状态设定到激活状态时，手动操纵剂量设定装置 在预定的方向上，由此释放锁定装置，并且导螺杆构件通过第一弹簧力装置向远侧移动预定距离，而与要设定的剂量的大小无关。

公开(公告)号：WO2011039216A3

公开(公告)日：2011-06-03

申请号：PCT/EP2010064407

申请日：2010-09-29

Applicant: SANOFI AVENTIS DEUTSCHLAND ,  VEASEY ROBERT ,  BILTON SIMON LEWIS ,  JONES CHRISTOPHER ,  KOUYOUMJIAN GAREN ,  MACDONALD CATHERINE ANNE

Inventor： VEASEY ROBERT ,  BILTON SIMON LEWIS ,  JONES CHRISTOPHER ,  KOUYOUMJIAN GAREN ,  MACDONALD CATHERINE ANNE

IPC: A61M5/24 ,  A61M5/315

CPC classification number: A61M5/3158 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31556 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/3126

Abstract: Resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing (10A, 10B, 10C), a piston rod (20) being rotatable and axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member (30) for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member (50). The drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing. When the drive assembly is in a drive mode, the interlocks are locked such that proximal movement of the piston rod from the end position to the start position is prevented. For switching the drive assembly from the drive mode to a reset mode, the piston rod is rotatable with respect to the drive member for unlocking the first interlock and the stop member and the piston rod are rotatable with respect to each other for unlocking the second interlock. When the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.

Abstract translation: 提供了用于药物输送装置的可重置驱动组件。 可重置的驱动组件可以包括壳体（10A，10B，10C），活塞杆（20）可在近端起始位置和远端位置之间相对于壳体旋转和轴向移动;驱动构件（30），用于 当分配剂量时，将活塞杆朝向终端位置远端移动，以及止挡件（50）。 驱动构件可操作以与活塞杆相互作用以形成可解锁的第一互锁，第一互锁可操作以阻止活塞杆相对于驱动构件的近端运动。 止动构件可操作以与活塞杆相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆相对于壳体的近端运动。 当驱动组件处于驱动模式时，互锁被锁定，从而防止活塞杆从终端位置到起始位置的近端运动。 为了将驱动组件从驱动模式切换到复位模式，活塞杆可相对于驱动构件旋转，用于解锁第一联锁装置，并且止动构件和活塞杆可相对于彼此旋转以解锁第二联锁装置 。 当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆向起始位置的近端运动。 此外，提供了药物递送装置和弹簧的使用。

公开(公告)号：WO1996017640A1

公开(公告)日：1996-06-13

申请号：PCT/RU1995000261

申请日：1995-12-04

Applicant: MEDINFODENT LTD. ,  BUTUZOV, Valentin Sergeevich ,  CHOUGAILOV, Igor Alexandrovich

Inventor： MEDINFODENT LTD.

IPC: A61M05/34

CPC classification number: A61M5/34 ,  A61M5/24 ,  A61M5/31515 ,  A61M5/31535 ,  A61M5/31581 ,  A61M5/31595 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/341

Abstract: The claimed syringe relates to medical instruments and can be used for a local analgesia. It contains joining body (1) and barrel (2) with gear rod (3) inside which has kinematical connection with driver pawl (5) and stopper pawl (6) of return move of the plunger (3), which are hinged on a rotary handle (7). Fastening unit (11) of double-edged needle (12) is fixed on one of the ends of the barrel which provides for the turn of the needle up to 180 DEG . A set of aspiration elements (16), spring (21) and squeezing bushing (22) permit to execute the aspiration test. The design of the driver unit permits to carry out an analgesia in two modes: discrete dosing, e.g., for the intraligamental analgesia, and free dosing for the conducting or infiltration analgesia.

Abstract translation: 所要求保护的注射器涉及医疗器械，并可用于局部镇痛。 它包括具有齿轮杆（3）的连接体（1）和筒体（2），其内部具有与驱动棘爪（5）的运动学连接和活塞（3）的返回移动的止动爪（6） 旋转手柄（7）。 双刃针（12）的紧固单元（11）固定在枪管的一端上，使针的转动高达180°。 一组抽吸元件（16），弹簧（21）和挤压衬套（22）允许执行抽吸测试。 驱动单元的设计允许以两种模式进行止痛：离散剂量，例如用于中度镇痛，以及用于导电或渗透镇痛的自由给药。

公开(公告)号：WO2017219157A1

公开(公告)日：2017-12-28

申请号：PCT/CH2017/000057

申请日：2017-06-13

Applicant: TECPHARMA LICENSING AG

Inventor： HIRSCHEL, Jürg ,  HOSTETTLER, Patrick ,  SCHEURER, Simon

IPC: A61M5/24 ,  A61M5/28 ,  A61M5/142

CPC classification number: A61M5/24 ,  A61M5/14248 ,  A61M5/1456 ,  A61M5/14566 ,  A61M5/2455 ,  A61M5/285 ,  A61M5/3232 ,  A61M2005/14268 ,  A61M2005/2407 ,  A61M2005/2414 ,  A61M2005/2418 ,  A61M2005/2437 ,  A61M2005/244 ,  A61M2005/2477 ,  A61M2005/2485

Abstract: A method for fixating a cartridge (26) adapted for receiving a medicament (134) to a cartridge holder (4d) of an injection device, comprising the steps of: - Providing a cartridge (26) having cylindrical glass barrel (125) and a septum (27) connected to the distal end of the glass barrel (125) using a crimp (27a), - Providing a cartridge holder (4d), Inserting the cartridge (26) into the cartridge holder (4d) such that the distal end of the cartridge (26) first enters the cartridge holder (4d) and is received by a second cavity (128) which is part of the cartridge holder (4d), Characterized by that the cartridge (26) is axially and rotationally fixed (4d) after the insertion step c) by at least one elastic attachment means (138) for attaching the cartridge (26) to the cartridge holder (4d).

Abstract translation: 一种用于固定适于将药物（134）接收到注射装置的药筒保持器（4d）的药筒（26）的方法，包括以下步骤： - 提供具有药筒（26）的药筒（26） （27a）连接到玻璃筒（125）的远端的圆柱形玻璃筒（125）和隔膜（27）， - 提供筒保持器（4d），将筒（26）插入筒保持器 （4d），使得药筒（26）的远端首先进入药筒保持器（4d）并由作为药筒保持器（4d）的一部分的第二腔（128）接收，其特征在于药筒（26） ）在插入步骤c）之后通过至少一个用于将药筒（26）附接到药筒保持器（4d）的弹性附接装置（138）轴向和旋转地固定（4d）。

公开(公告)号：WO2016196934A1

公开(公告)日：2016-12-08

申请号：PCT/US2016/035720

申请日：2016-06-03

Applicant: MEDIMOP MEDICAL PROJECTS LTD. ,  WEST PHARMACEUTICAL SERVICES, INC.

Inventor： BAR-EL, Yossi ,  YIGAL, Gil ,  FILMAN, Reuven, Y.

IPC: A61M5/24 ,  A61M5/20 ,  A61M5/142

CPC classification number: A61M5/2422 ,  A61M5/14244 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/24 ,  A61M5/2466 ,  A61M2005/2414 ,  A61M2005/2437 ,  A61M2005/2477 ,  A61M2005/2496

Abstract: A method and assembly are disclosed for interfacing between a drug cartridge and a drug delivery device. Optionally, the drug delivery device includes a compartment that retains the cartridge during drug delivery and/or a stopper pushing assembly mounted to the device behind (proximal to) the compartment. In some embodiments, the cartridge may be inserted laterally into the compartment in front of the pushing assembly. For example, the delivery device may include a moving cartridge bay. The cartridge is optionally inserted into the bay and/or the bay and cartridge optionally move into the cartridge compartment. Alternatively or additionally, the cartridge compartment may have a proximal opening into which the cartridge is inserted and/or the pushing assembly may be moved into position after insertion of the cartridge. In some embodiments the cartridge may have a distal seal that is broken by a longitudinal movement.

Abstract translation: 公开了用于药物盒和药物递送装置之间的接口的方法和组件。 任选地，药物递送装置包括在药物递送期间保持药筒和/或在隔室后面（靠近）安装到装置上的止动器推动组件的隔室。 在一些实施例中，盒可以横向插入到推动组件前面的隔室中。 例如，传送设备可以包括移动盒托架。 墨盒可选地插入托架和/或托架和墨盒可选地移动到墨盒隔间中。 替代地或另外地，盒室可以具有近端开口，盒被插入到其中，和/或推动组件可以在插入盒之后移动到位。 在一些实施例中，盒可以具有由纵向运动破坏的远侧密封件。

公开(公告)号：WO2016055635A1

公开(公告)日：2016-04-14

申请号：PCT/EP2015/073443

申请日：2015-10-09

Applicant: SANOFI

Inventor： EARDLEY, Zoë Georgina ,  DRAPER, Paul Richard

IPC: A61M5/20 ,  A61M5/24 ,  A61M5/315

CPC classification number: A61M5/31543 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/2485 ,  A61M2005/3126 ,  A61M2005/3154 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/584

Abstract: The present invention is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose setting element (60) rotatable relative to the housing (10) during dose setting and dose dispensing, a drive member (40) coupled to the dose setting member (60) via a clutch (120), and a piston rod (30) coupled to the housing (10) and to the drive member (40). Further, the device further comprises a cartridge holder (20) removably attached to the housing (10) and a reset element (150), which is axially constrained to the dose setting element (60), and at least one spring (130) acting on the reset element (150), such that, if the cartridge holder (20) is detached from the housing (10), the reset element (150) is axially moved relative to the housing (10) into a position in which the dose setting element (60) is rotationally constrained to the housing (10) and the drive member (40) is allowed to rotate relative to the housing (10).

Abstract translation: 本发明一般涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 所述装置包括壳体（10），剂量设定元件（60），其在剂量设定和剂量分配期间可相对于所述壳体（10）旋转;驱动构件（40），其通过离合器（ 120）和联接到壳体（10）和驱动构件（40）的活塞杆（30）。 此外，该装置还包括可移除地附接到壳体（10）的盒保持器（20）和轴向约束到剂量设定元件（60）的复位元件（150），以及至少一个弹簧 在所述复位元件（150）上，使得如果所述盒保持器（20）与所述壳体（10）分离，则所述复位元件（150）相对于所述壳体（10）轴向移动到其中所述剂量 设置元件（60）被旋转地约束到壳体（10），并且驱动构件（40）被允许相对于壳体（10）旋转。