公开(公告)号：WO1994005617A1

公开(公告)日：1994-03-17

申请号：PCT/US1993008061

申请日：1993-08-25

Applicant: NEW YORK UNIVERSITY

Inventor： NEW YORK UNIVERSITY ,  MCNELIS, Edward

IPC: C07C45/30

CPC classification number: C07C49/813 ,  C07C35/29 ,  C07C45/512 ,  C07C45/65 ,  C07C45/68 ,  C07C47/24 ,  C07C49/227 ,  C07C49/23 ,  C07C49/235 ,  C07C49/687 ,  C07C49/693 ,  C07C49/697 ,  C07C49/798

Abstract: Alternative methods for synthesizing haloenones and haloalkenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, using such haloenones and haloalkenes.

Abstract translation: 用于合成卤代酮和卤代烯烃的替代方法及其用作合成取代或未取代的烷基和芳基取代的烯酮和烯烃（包括他莫昔芬和他莫昔芬类似物）的起始材料，使用这种卤代酮和卤代烯烃。

公开(公告)号：WO1982000030A1

公开(公告)日：1982-01-07

申请号：PCT/US1981000816

申请日：1981-06-16

Applicant: FRITZSCHE DODGE & OLCOTT INC

Inventor： FRITZSCHE DODGE & OLCOTT INC ,  WILLIS B ,  MACK R ,  CHRISTENSON P

IPC: C07C35/22

CPC classification number: C11B9/0053 ,  C07C29/00 ,  C07C29/58 ,  C07C35/36 ,  C07C35/46 ,  C07C43/188 ,  C07C45/63 ,  C07C49/23 ,  C07C403/16 ,  C07C2601/14 ,  C07C2602/26 ,  C07F7/1804

Abstract: Compounds useful as fragrance materials having the structure wherein each of R1, R2, and R3 are hydrogen or methyl can be prepared by reacting a halogen-containing cyclohexane, having the structure wherein each of R1, R2, and R3 are hydrogen or methyl and X is a halogen, with a reagent capable of effecting intramolecular cyclization.

公开(公告)号：WO1992021643A1

公开(公告)日：1992-12-10

申请号：PCT/US1992002340

申请日：1992-03-18

Applicant: UNIVERSITY OF HAWAII

Inventor： UNIVERSITY OF HAWAII ,  ASATO, Alfred, E. ,  LIU, Robert, S., H.

IPC: C07C53/132

CPC classification number: C07C251/18 ,  A61K31/07 ,  A61K31/19 ,  A61K31/20 ,  A61K31/215 ,  A61K31/275 ,  C07C33/16 ,  C07C33/34 ,  C07C33/44 ,  C07C45/298 ,  C07C45/44 ,  C07C45/515 ,  C07C45/67 ,  C07C45/74 ,  C07C47/225 ,  C07C47/24 ,  C07C47/445 ,  C07C47/548 ,  C07C49/23 ,  C07C57/42 ,  C07C63/66 ,  C07C69/608 ,  C07C69/65 ,  C07C69/76 ,  C07C2602/30

Abstract: Novel azulenic retinoid compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents. The compositions of the present invention will also find use in treating dermatological disorders such as acne and psoriasis, as well as dermatologically-related conditions such as repair and effacement of wrinkles.

公开(公告)号：WO1981002518A1

公开(公告)日：1981-09-17

申请号：PCT/US1981000295

申请日：1981-03-04

Applicant: FRITZSCHE DODGE & OLCOTT INC

Inventor： FRITZSCHE DODGE & OLCOTT INC ,  WILLIS B ,  MACK R ,  CHRISTENSON P

IPC: A61K07/46

CPC classification number: C07C403/16 ,  C07C45/63 ,  C07C49/23 ,  C07C2601/14 ,  C11B9/0034

Abstract: Novel compounds useful as fragrance materials which have the structure (FORMULA) wherein the dashed line may be either a carbon-carbon single bond or a carbon-carbon double bond; R u, R u and R u are each the same or different and each represents hydrogen or methyl; and X is halogen. The invention also provides methods of preparing these compounds from readily available cyclohexene derivatives and fragrance compositions which include the compounds.

Abstract translation: 用作具有结构（芳香族）的香料的新型化合物，其中虚线可以是碳 - 碳单键或碳 - 碳双键; R u，R u和R u各自相同或不同，各自表示氢或甲基; X为卤素。 本发明还提供了由容易获得的环己烯衍生物和包括该化合物的香料组合物制备这些化合物的方法。