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    POLY(9,9'-SPIRO-BISFLUORENES), THE PRODUCTION AND USE OF SAME
    4.
    发明申请
    POLY(9,9'-SPIRO-BISFLUORENES), THE PRODUCTION AND USE OF SAME 审中-公开
    聚（9,9'- SPIROBISFLUORENE），生产及其用途

    公开(公告)号：WO1997020877A2

    公开(公告)日：1997-06-12

    申请号：PCT/EP1996005091

    申请日：1996-11-19

    Applicant: JAPAT LTD. ,  CIBA-GEIGY JAPAN LIMITED ,  RIETZ, Ralf-Roman ,  WERNET, Wolfgang

    Inventor： JAPAT LTD. ,  CIBA-GEIGY JAPAN LIMITED

    IPC: C08G61/00

    CPC classification number: C09K11/06 ,  C07C17/12 ,  C07C25/22 ,  C07C49/792 ,  C07C49/813 ,  C07C63/49 ,  C08G61/00 ,  Y10S428/917

    Abstract: Poly(bis-9,9'-fluorenes) are disclosed with identical or different recurring structural elements of formula (I), in which the two R1 groups independently of one another stand for H, C1-C18-alkyl, C6-C14-aryl, C7-C15-aralkyl, C1-C18-alkoxy, R2-(O-CnH2n)m-O-, C1-C18 alkylthio, C1-C18-dialkylamino, -C(O)OH, -C(O)O-C1-C18-alkyl, -C(O)-N(C1-C18-alkyl)2, SO3H, -SO3-C1-C18-alkyl, -SO2-N(C1-C18-alkyl)2, C1-C17-alkyl-C(O)-O- or C1-C17-alkyl-C(O)-, R2 stands for H or C1-C12-alkyl, n is a number between 2 and 6 and m is a number between 1 and 12. The polymers can be used on their own or mixed with at least one additional fluorophore whose absorption band overlaps with the emission band (fluorescence emission) of the polymer of formula (I), as an active radiating layer for light-emitting diodes, screens and display elements.

    Abstract translation: 聚（双 - 9,9'fluorene），其具有相同或不同的重复结构式（I）的元件，其中两个R 1独立地为H，C1-C18烷基，C6-C14芳基，C7-C15芳烷基，C1-C18 烷氧基，R 2 - （O-为CnH2n）米O-，C1-C18烷硫基，C1-C18二烷基氨基，-C（O）OH，-C（O）O-C1-C18烷基，-C（O） -N（C1-C18烷基）2，-SO 3 H，-SO 3-C1-C18烷基，-SO2-N（C1-C18烷基）2，C1-C17烷基-C（O）-O-或 C1-C17烷基-C（O） - ，R2是H或C1-C12烷基，n是一个数为2至6，并且m为1至12个 可以重叠的聚合物中，作为活性放射线层为发光二极管，显示和显示元件单独地或与至少一种另外的荧光团，其发射带（Fluoreszensemmission）式（I）的聚合物的吸收谱带的混合物。

    PROCESS FOR THE PRODUCTION OF 2-(SUBSTITUTED BENZOYL)-1,3 CYCLOHEXANEDIONES
    5.
    发明申请
    PROCESS FOR THE PRODUCTION OF 2-(SUBSTITUTED BENZOYL)-1,3 CYCLOHEXANEDIONES 审中-公开
    2-（取代苯甲酰基）-1,3环己酮的制备方法

    公开(公告)号：WO1996022957A1

    公开(公告)日：1996-08-01

    申请号：PCT/GB1996000081

    申请日：1996-01-16

    Applicant: ZENECA LIMITED ,  BROWN, Stephen, Martin ,  RAWLINSON, Howard ,  WIFFEN, Jonathan, William

    Inventor： ZENECA LIMITED

    IPC: C07C45/54

    CPC classification number: C07C315/04 ,  C07C45/54 ,  C07C317/24 ,  C07C49/792

    Abstract: A process for preparing a compound of formula (I), where R , R , R , R , R and R are independently hydrogen or C1-6 alkyl; R is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R , R and R independently are hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NO2, phenoxy or substituted phenoxy; RbS(O)n Om in which m is 0 or 1, n is 0, 1 or 2 and Rb is C1-4 alkyl, C1-4 haloalkyl, phenyl or benzyl, NHCORc in which Rc is C1-4 alkyl, NRdRe in which Rd and Re independently are hydrogen or C1-4 alkyl; RfC(O)- in which Rf is hydrogen, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy; SO2NRgRh in which Rg and Rh independently are hydrogen or C1-4 alkyl; or any two of R , R and R together with the carbon atoms to which they are attached form a 5 or 6 membered heterocyclic ring containing up to three heteroatoms selected from O, N or S and which may be optionally substituted by C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, =NOC1-4 alkyl, or halogen; which process comprises the rearrangement of a compound of formula (II), where R , R , R , R , R , R , R , R , R and R are as defined in relation to formula (I), in the presence of a base and a polar aprotic solvent characterised in that the process is carried out in a reaction medium substantially free of hydrogen cyanide or cyanide anion.

    Abstract translation: 制备式（I）化合物的方法，其中R 1，R 2，R 3，R 4，R 5和R 6独立地是氢或C 1-6烷基 ; R 7是卤素，氰基，NO 2，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基或R a，其中R a是C 1-4烷基; R 8，R 9和R 10独立地是氢，卤素，C 1-4烷基，C 1-4烷氧基，C 1-4卤代烷基，C 1-4卤代烷氧基，CN，NO 2，苯氧基或取代的苯氧基; RbS（O）n Om，其中m为0或1，n为0,1或2，Rb为C1-4烷基，C1-4卤代烷基，苯基或苄基，NHCORc，其中Rc为C1-4烷基，NRdRe为 哪个Rd和Re独立地是氢或C 1-4烷基; RfC（O） - ，其中R f为氢，C 1-4烷基，C 1-4卤代烷基或C 1-4烷氧基; 其中Rg和Rh独立地为氢或C1-4烷基的SO2NRgRh; 或R 8，R 9和R 10中的任何两个与它们所连接的碳原子一起形成含有至多三个选自O，N或S的杂原子的5或6元杂环，并且其中 可以任选地被C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，= NOC 1-4烷基或卤素取代; 该方法包括式（II）化合物的重排，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7， 在碱和极性非质子溶剂的存在下，R 8，R 9和R 10如关于式（I）所定义，其特征在于该方法在基本上无反应的反应介质中进行 的氰化氢或氰化物阴离子。

    HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE
    6.
    发明申请
    HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
    杂环化合物，其制备和使用

    公开(公告)号：WO1996015100A1

    公开(公告)日：1996-05-23

    申请号：PCT/DK1995000444

    申请日：1995-11-08

    Applicant: NOVO NORDISK A/S ,  PELLICCIARI, Roberto ,  LUNEIA, Roberto ,  LOMBARDI, Grazia ,  MORONI, Flavio

    Inventor： NOVO NORDISK A/S

    IPC: C07C229/46

    CPC classification number: C07D257/04 ,  C07C17/2637 ,  C07C45/30 ,  C07C45/46 ,  C07C61/39 ,  C07C63/49 ,  C07C229/50 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/42 ,  C07D307/84 ,  C07D333/68 ,  C07C22/04 ,  C07C47/546 ,  C07C49/84 ,  C07C49/792

    Abstract: The present invention relates to therapeutically active heterocyclic compounds of formula (I), wherein n is 0, 1 or 2; and X is -O-, -S, -N(R )- or -CH2-; and R is H, NH2, NHR or OH; and R and R independently are H, COOH; COOR , CONH2, CONHR , CON(R )2, CONHSO2R or tetrazole; and R is H, OH, NH2, NHR ; CF3, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, C3-6-cycloalkyl, phenyl or C1-4-alkoxy; and R is H, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, phenyl or C3-6-cycloalkyl; and ring A can be partly or completely saturated or aromatic, or a salt thereof with a pharmaceutically acceptable acid or base, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to the metabotropic glutamate receptor system.

    Abstract translation: 本发明涉及式（I）的治疗活性杂环化合物，其中n为0,1或2; 并且X是-O - ， - S，-N（R 5） - 或-CH 2 - ; 并且R 1是H，NH 2，NHR 5或OH; R 2和R 3独立地为H，COOH; COOR 5，CONH 2，CONHR 5，CON（R 5）2，CONHSO 2 R 5或四唑; 且R 4为H，OH，NH 2，NHR 5; CF 3，C 1-8烷基，C 2-8 - 烯基，C 2-8 - 炔基，C 3-6 - 环烷基，苯基或C 1-4 - 烷氧基; R 5为H，C 1-8 - 烷基，C 2-8 - 烯基，C 2-8 - 炔基，苯基或C 3-6 - 环烷基; 并且环A可以是部分或完全饱和的或芳族的，或其与药学上可接受的酸或碱的盐，其制备方法和包含该化合物的药物组合物。 该新化合物可用于治疗与代谢型谷氨酸受体系统相关的中枢神经系统疾病。

    CYCLOHEXANE DERIVATIVES
    9.
    发明申请
    CYCLOHEXANE DERIVATIVES 审中-公开
    环己酮衍生物

    公开(公告)号：WO1986005486A1

    公开(公告)日：1986-09-25

    申请号：PCT/EP1986000164

    申请日：1986-03-21

    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ... ,  POHL, Ludwig ,  SCHEUBLE, Bernhard ,  HITTICH, Reinhard ,  EIDENSCHINK, Rudolf ,  KURMEIER, Hans-Adolf ,  WÄCHTLER, Andreas

    Inventor： MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER ...

    IPC: C07C121/60

    CPC classification number: C07C255/00 ,  C07C13/28 ,  C07C25/18 ,  C07C43/184 ,  C07C43/188 ,  C07C43/21 ,  C07C43/225 ,  C07C45/004 ,  C07C45/46 ,  C07C49/313 ,  C07C49/792 ,  C09K19/3003 ,  C09K19/3068

    Abstract: Cyclohexane derivatives of formula R -A -Z -A -R in which R and R are in each case an alkyl group with 1-10 C atoms, in which also one or two non neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups and/or -CH=CH- groups, one of the remainder R and R , also H, F, Cl, Br, CN or R -A -Z -, A is -A-, A -A- or -A-A -, A is a substituted trans-1,4-cyclohexyl group substituted in 2 , 3 , 5 and/or 6 position, substituted once or substituted several times by F and/or Cl and/or Br and/or CN and/or an alkyl group or a fluoridated alkyl group, each with 1-10 atoms, in which also one or two not neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups; which also, as the case may be, can be substituted in 1 and/or 4 position, A , A and A are in each case an unsubstituted 1,4-phenylene, or a 1,4-phenyl substituted by one or two F and/or Cl atoms and/or CH3 groups and/or CN groups, in which also one or two CH groups can be replaced by N atoms and/or NO, 1,4-cyclohexylene, in which one or two not neighboring CH2 groups may be substituted by O atoms, 1,3-dithiane-2,5-diyl, piperidine-1,4-diyl, 1,4-bicyclo(2,2,2)-octylene-, decahydronaphthalene-2,6-diyl-, or 1,2,3,4-tetrahydronaphthalene-2,6-diyl groups, Z and Z are either -CO-O-, -O-CO-, -CH2CH2-, OCH2-, -CH2O or a single link, and R is H, an alkyl group with 1-10, in which also one or two not-neighboring CH2 groups can be replaced by O atoms and/or -CO- groups and/or -CO-O- groups and/or -CH=CH- groups; F, Cl,Br or CN, it being understood that if Z = -CO-O- A in beta -position, to the -CO-O- bridge it carries no equatorial substitutes, are suitable as components for liquid crystal phases.

    Abstract translation: 式R 1 -A 1 -Z 1 -A 2 -R 2的环己烷衍生物，其中R 1和R 2各自为具有1-10个 C原子，其中一个或两个不相邻的CH 2基团可以被O原子和/或-CO-基团和/或-CO-O-基团和/或-CH = CH-基团取代，其余的R 1和R 2，还有H，F，Cl，Br，CN或R 3 -A 3 - 2，A 1是-A-，A 4 - A-或-AA 4 - ，A是在2，3，5和/或6位上取代的取代的反式-1,4-环己基，取代一次或 被F和/或Cl和/或Br和/或CN和/或烷基或氟化烷基取代几次，每个具有1-10个原子，其中一个或两个不相邻的CH 2基团可以被 O原子和/或-CO-基团和/或-CO-O-基团; 根据情况也可以在1位和/或4位取代，A 2，A 3和A 4在每种情况下都是未取代的1,4- 亚苯基或被一个或两个F和/或Cl原子和/或CH 3基团和/或CN基团取代的1,4-苯基，其中一个或两个CH基团可以被N原子和/或NO， 其中一个或两个不相邻的CH2基团可以被O原子取代的1,4-亚环己基，1,3-二噻烷-2,5-二基，哌啶-1,4-二基，1,4-双环（2， 2,2,2-辛基 - 十氢萘-2,6-二基或1,2,3,4-四氢化萘-2,6-二基，Z 1和Z 2均为-CO-O - ， - O - CO - ， - CH 2 CH 2 - ，OCH 2 - ， - CH 2 O或单环，并且R 3是H，具有1-10的烷基，其中还有一个或两个不相邻的CH 2基团 被O原子和/或-CO-基团和/或-CO-O-基团和/或-CH = CH-基团取代; F，Cl，Br或CN，可以理解，如果β-β中的Z 1 = -CO-O- A 1，则对于-CO-O-桥，其不携带赤道替代物，适合作为组分 用于液晶相。

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