公开(公告)号：WO1994001100A1

公开(公告)日：1994-01-20

申请号：PCT/US1993004090

申请日：1993-04-30

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  LIANG, Tehming

IPC: A61K31/20

CPC classification number: C07D337/00 ,  A61K8/361 ,  A61K8/37 ,  A61K8/4906 ,  A61K8/4973 ,  A61K8/67 ,  A61K31/20 ,  A61K31/23 ,  A61K31/353 ,  A61K31/565 ,  A61K45/06 ,  A61K2800/782 ,  A61Q5/00 ,  A61Q19/00 ,  C07C53/21 ,  C07C57/52 ,  C07C57/56 ,  C07C61/16 ,  C07C61/40 ,  C07C69/63 ,  C07C69/65 ,  C07C69/675 ,  C07C69/716 ,  C07C69/738 ,  C07C69/88 ,  C07D209/48 ,  C07D225/02 ,  C07D313/00 ,  A61K2300/00

Abstract: Disclosed is a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their antiandrogenic activity in treating disorders related to androgenic activities.

Abstract translation: 公开了一类新颖的抗雄激素化合物，包括饱和和不饱和脂肪酸，其衍生物和合成类似物，其合成方法及其在治疗与雄激素活性相关的疾病中的用途。 还公开了使用已知的化合物在治疗与雄激素活性相关的疾病中具有抗雄激素活性的先前已知的化合物。

公开(公告)号：WO1990003979A2

公开(公告)日：1990-04-19

申请号：PCT/US1989004312

申请日：1989-10-02

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  PATAKI, John ,  HARVEY, Ronald, G.

IPC: C07J01/100

CPC classification number: C07J63/008 ,  A61K31/045 ,  A61K31/05 ,  A61K31/12 ,  A61K31/22 ,  C07C39/17 ,  C07C45/513 ,  C07C45/516 ,  C07C49/657 ,  C07C49/665 ,  C07C49/747 ,  C07C49/753 ,  C07C49/792 ,  C07C2603/26 ,  C07J1/0055 ,  C07J1/0059 ,  C07J1/007 ,  C07J1/0088

Abstract: Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.

Abstract translation: 公开了新型抗雄激素，包括二氢菲衍生物，其合成方法及其在治疗与过度雄激素活性相关的疾病中的用途。

公开(公告)号：WO1989009223A1

公开(公告)日：1989-10-05

申请号：PCT/US1989001238

申请日：1989-03-24

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  CHANG, Chawnshang

IPC: C07H21/04

CPC classification number: C12N15/8509 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/721 ,  C07K16/2869 ,  C12Q1/6876 ,  C12Q2600/158

Abstract: Disclosed are DNA sequences encoding DNA binding polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti-androgen receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR and TR2-related nucleic acids.

Abstract translation: 公开了编码包括雄激素受体（AR）和TR2多肽的DNA结合多肽的DNA序列。 说明性地，人和大鼠AR-cDNA具有79kD和98kD多肽表达产物，它们可被人自身免疫抗雄激素受体抗体免疫沉淀，并能够以高亲和力特异性结合雄激素。 还公开了用于检测雄激素受体和TR2多肽的抗体和免疫学方法和材料以及用于检测AR和TR2相关核酸的杂交方法和材料。

公开(公告)号：WO1991007423A1

公开(公告)日：1991-05-30

申请号：PCT/US1990006015

申请日：1990-10-19

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  CHANG, Chawnshang

IPC: C07H21/00

CPC classification number: C07K16/18 ,  C07K14/47 ,  C07K14/721

Abstract: Disclosed are DNA sequences encoding DNA binding polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti-androgens receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR-and TR2-related nucleic acids.

Abstract translation: 公开了编码包括雄激素受体（AR）和TR2多肽的DNA结合多肽的DNA序列。 说明性地，人和大鼠AR-cDNA具有79kD和98kD多肽表达产物，其可被人自身免疫抗雄激素受体抗体免疫沉淀，并且能够以高亲和力特异性结合雄激素。 还公开了用于检测雄激素受体和TR2多肽的抗体和免疫学方法和材料以及用于检测AR和TR2相关核酸的杂交方法和材料。