摘要:
The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The synthesis of new compounds is disclosed herein, together with experiments demonstrating their activity in cytotoxicity (IC50) assays against cancer cell lines and their preferential toxicity toward cancerous cells (vs. non-malignant cells). The compounds are also useful in reversing MDR (multidrug resistance).
摘要:
The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.
摘要:
Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulf?nyl- and sulfonyl- analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.
摘要:
Compounds of Formula (I), or pharmaceutically acceptable salts thereof: wherein R 2 , R 3 , X, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要:
Die Erfindung betrifft ein Verfahren zur Herstellung von Ammoniumhexafluorophosphaten der allgemeinen Formel (1) worin R 1 , R 2 , R 3 und R 4 die in den Ansprüchen und in der Beschreibung genannten Bedeutungen haben kann, neue Ammoniumhexafluorophosphate als solche sowie deren Verwendung zur Herstellung pharmazeutisch wirksamer Verbindungen.
摘要:
The present invention discloses novel methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including novel oxoazepanylacetamide derivatives useful for viral inhibition.
摘要:
Methods for preparing 2,6-diaryl piperidine derivatives are described. More particularly, 2,6-diaryl piperidines having formula 1-4 are prepared by cyclocondensation of an aryl or heteroaryl aldehyde with 1,3-acetonedicarboxylic acid.