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    ATTENUATED MUTANT NEWCASTLE DISEASE VIRUS STRAINS FOR IN OVO VACCINATION, METHOD FOR PREPARING AND THEIR USE
    8.
    发明申请
    ATTENUATED MUTANT NEWCASTLE DISEASE VIRUS STRAINS FOR IN OVO VACCINATION, METHOD FOR PREPARING AND THEIR USE 审中-公开
    用于OVO疫苗接种的减毒突变新城疫病毒株，制备方法及其用途

    公开(公告)号：WO2003030932A1

    公开(公告)日：2003-04-17

    申请号：PCT/EP2002/011081

    申请日：2002-10-02

    申请人： CENTRUM VOOR ONDERZOEK IN DIERGENEESKUNDE EN AGROCHEMIE ,  MAST, Jan ,  MEULEMANS, Guy

    发明人： MAST, Jan ,  MEULEMANS, Guy

    IPC分类号： A61K39/17

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  C07K16/1027 ,  C12N2760/18122 ,  C12N2760/18134

    摘要： The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains. In particular, it relates to an attenuated mutant Newcastle's disease La SotaNewcastle disease virus strain suitable for in ovo vaccination of avian species comprising a mutation in the gene sequences encoding the HN and/or F glycoproteins of said virus resulting in an altered expression of said glycoproteins. Furthermore, the invention relates to a vaccine composition comprising said attenuated mutant Newcastle's disease La Sota virus strain, and to the use of said attenuated mutant Newcastle's disease La Sota virus strain for the preparation of a vaccine for in ovo vaccination of avian species against Newcastle's disease. Finally, the present invention also concerns a method for producing a vaccine for in ovo vaccination of avian species, said vaccine comprising attenuated mutant avian virus strains, which are selected using virus specific antibodies.

    摘要翻译： 本发明涉及新的减毒突变New Castle's病La SotaNewcastle病毒株。 具体涉及适用于卵内疫苗接种禽类的减毒突变的新城疫La SotaNewcastle病病毒株，其包含编码所述病毒的HN和/或F糖蛋白的基因序列中的突变，导致所述糖蛋白的改变的表达 。 此外，本发明涉及包含所述减毒突变新城病La Sota病毒株的疫苗组合物，以及所述减毒突变新城疫La Sota病毒株用于制备用于卵内疫苗接种禽类抵抗新城疫的疫苗的用途 。 最后，本发明还涉及生产用于卵内疫苗接种禽类的疫苗的方法，所述疫苗包含使用病毒特异性抗体选择的减毒突变禽类病毒株。

    LIVE VACCINES AND METHODS OF TREATMENT THEREWITH
    9.
    发明申请
    LIVE VACCINES AND METHODS OF TREATMENT THEREWITH 审中-公开
    活体疫苗及其治疗方法

    公开(公告)号：WO99053950A2

    公开(公告)日：1999-10-28

    申请号：PCT/US1999/008530

    申请日：1999-04-16

    IPC分类号： A61K39/12 ,  A61K39/155 ,  A61K39/17 ,  A61P31/12 ,  A61K38/21

    CPC分类号： A61K39/17 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/525 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55522 ,  C12N2760/18134 ,  C12N2760/18171 ,  A61K2300/00

    摘要： Disclosed herein are methods and pharmaceutical formulations for administering vaccines to birds. In preferred embodiments, the invention provides methods of administering live pathogenic virus vaccines to birds in ovo, more preferably, during the last quarter of in ovo incubation. Interferon, more preferably, Type I interferon, may be advantageously administered in conjunction with live virus vaccines to decrease the pathogenicity thereof. Interferon must be provided at doses sufficient to protect against pathogenicity of the live vaccine, but not at doses so high as to prevent the host from mounting an active immune response. Further provided are pharmaceutical formulations comprising effective doses of live vaccine and interferon. Finally, the present invention provides methods of administering interferon together with live vaccines to young avians to effectively overcome the interfering effects of maternal antibodies.

    摘要翻译： 本文公开了用于向鸟类施用疫苗的方法和药物制剂。 在优选的实施方案中，本发明提供了在卵内向鸟类施用活的致病病毒疫苗的方法，更优选在卵子孵育的最后四分之一中。 干扰素，更优选I型干扰素可以有利地与活病毒疫苗一起施用以降低其致病性。 必须以足以防止活疫苗致病性的剂量提供干扰素，但不能以如此高的剂量提供，以防止宿主发生主动免疫反应。 还提供了包含有效剂量的活疫苗和干扰素的药物制剂。 最后，本发明提供了将干扰素与活疫苗一起给予年轻禽鸟的方法，以有效克服母体抗体的干扰作用。

    RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY
    10.
    发明申请
    RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY 审中-公开
    重组非致病性MDV载体提供多重免疫

    公开(公告)号：WO2013057235A1

    公开(公告)日：2013-04-25

    申请号：PCT/EP2012/070727

    申请日：2012-10-19

    申请人： INTERVET INTERNATIONAL B.V. ,  SONDERMEIJER, Paulus Jacobus Antonius ,  VERSTEGEN, Iwan

    发明人： SONDERMEIJER, Paulus Jacobus Antonius ,  VERSTEGEN, Iwan

    IPC分类号： A61K39/17 ,  A61K39/12

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N2710/16343 ,  C12N2720/10034 ,  C12N2760/18134

    摘要： The present invention relates to the field of veterinary vaccines, in particular to that of vector vaccines for poultry based on recombinant nonpathogenic Marek's disease virus (npMDV). The recombinant npMDV of the invention expresses stably and effectively two heterologous genes each originating from a different micro-organism: the fusion protein gene from Newcastle disease virus, and the viral protein 2 gene from infectious bursal disease virus. A vaccine based on this recombinant npMDV can be used to induce in poultry a protective immune response not only against Marek's disease, but also against Newcastle disease and Infectious bursal disease. The invention also relates to methods and uses involving the recombinant npMDV, expression cassette, infected host cells, and vaccines.

    摘要翻译： 本发明涉及兽医疫苗领域，特别涉及基于重组非致病性马立克氏病病毒（npMDV）的禽类载体疫苗领域。 本发明的重组npMDV稳定而有效地表达了两种来自不同微生物的异源基因：来自新城疫病毒的融合蛋白基因和来自传染性法氏囊病病毒的病毒蛋白2基因。 基于该重组npMDV的疫苗可用于在家禽中诱导不仅对马立克氏病的保护性免疫应答，而且还针对新城疫和传染性法氏囊病。 本发明还涉及涉及重组npMDV，表达盒，感染的宿主细胞和疫苗的方法和用途。