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    BROAD-SPECTRUM VACCINE AGAINST AVIAN REOVIRUS
    1.
    发明申请
    BROAD-SPECTRUM VACCINE AGAINST AVIAN REOVIRUS 审中-公开
    BROAD-SPECTRUM VACCINE AGAIN AVIAN REVVIRUS

    公开(公告)号：WO2016050961A1

    公开(公告)日：2016-04-07

    申请号：PCT/EP2015/072810

    申请日：2015-10-02

    Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

    Inventor： POUWELS, Henk ,  ZANDE VAN DE, Saskia

    IPC: A61K39/15 ,  A61K39/12

    CPC classification number: A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2720/12034

    Abstract: A broad-spectrum vaccine against avian Reovirus is disclosed, which is effective in reducing the infection of avian Reovirus in an avian target. The vaccine comprises antigenic material derived from avian Reovirus of two genotype groups: 1 and 4, as defined herein. This vaccine is effective against all avian Reoviruses, homologous or heterologous to the vaccine, including recent virulent break-through strains.

    Abstract translation: 公开了针对禽呼肠弧病毒的广谱疫苗，其有效减少鸟类呼肠病毒在禽类靶点中的感染。 疫苗包含衍生自两种基因型组的禽类呼肠孤病毒的抗原性材料：如本文所定义的1和4。 该疫苗对所有禽流感病毒有效，与疫苗同源或异源，包括最近有毒的突变株。

    COMBINED IN ACTIVATED VACCINE,READY FOR ADMINISTRATION AND PROCESS FOR THE PREPARATION OF SUCH VACCINE,ACTIVE AGAINST EGG PRODUCTION DROP CAUSED BY ADENO LIKE VIRUSES AND AGAINST DISEASES CAUSED BY REO VIRUSES
    2.
    发明申请
    COMBINED IN ACTIVATED VACCINE,READY FOR ADMINISTRATION AND PROCESS FOR THE PREPARATION OF SUCH VACCINE,ACTIVE AGAINST EGG PRODUCTION DROP CAUSED BY ADENO LIKE VIRUSES AND AGAINST DISEASES CAUSED BY REO VIRUSES 审中-公开
    在活化疫苗中组合，准备用于制备这种疫苗的制剂和方法，对由ADENO类病毒引起的和由抗病毒药物引起的疾病引起的产卵引起的活性

    公开(公告)号：WO1980002505A1

    公开(公告)日：1980-11-27

    申请号：PCT/NL1980000019

    申请日：1980-05-21

    Applicant: GIST BROCADES NV ,  APONTOWEIL P ,  KRASSELT M ,  KOK J

    Inventor： GIST BROCADES NV

    IPC: A61K39/295

    CPC classification number: A61K39/235 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2710/10034 ,  C12N2720/12034

    Abstract: The vaccine is prepared by mixing a reo virus containing liquid, obtained by cultivation of a reo virus, followed by inactivation of this liquid and optionally homogenising it, with a adeno like virus (ALV) containing liquid, obtained by cultivation of an ALV, followed by inactivation of this liquid and optionally homogenising it, and adding the mixture to an oily phase containing as essential components at least one of the components selected from the group consisting of light mineral paraffenic oils, plant oils and naphtenic mineral oils, and one or more emulsifiers, such as non-ionic surface-active compounds derived from alkylene oxide and/or hexahydric alcohols and/or higher natural fatty acids such as esters or ester-ethers optionally followed by homogenising and/or addition of a preservative.

    Abstract translation: 通过混合通过培养reo病毒获得的含有液体的reo病毒，然后将该液体灭活并任选地使其与含有通过培养ALV获得的含有液体的腺病毒（ALV））均化，制备疫苗，随后 通过灭活该液体并任选地使其均化，并将混合物加入到含有作为必需成分的油相中，所述组分选自轻质矿物油，植物油和萘矿物油中的至少一种成分，以及一种或多种 乳化剂，例如衍生自环氧烷和/或六元醇的非离子表面活性化合物和/或较高级天然脂肪酸如酯或酯 - 醚，任选地随后均化和/或添加防腐剂。

    NSP10 SELF-ASSEMBLING FUSION PROTEINS FOR VACCINES, THERAPEUTICS, DIAGNOSTICS AND OTHER NANOMATERIAL APPLICATIONS
    8.
    发明申请
    NSP10 SELF-ASSEMBLING FUSION PROTEINS FOR VACCINES, THERAPEUTICS, DIAGNOSTICS AND OTHER NANOMATERIAL APPLICATIONS 审中-公开
    用于疫苗，治疗学，诊断和其他纳米应用的NSP10自组装融合蛋白

    公开(公告)号：WO2017066484A3

    公开(公告)日：2017-05-26

    申请号：PCT/US2016056904

    申请日：2016-10-13

    Applicant: CARTER DANIEL C

    Inventor： CARTER DANIEL C

    IPC: A61K35/76 ,  C07K14/165 ,  C07K16/10

    CPC classification number: A61K39/12 ,  A61K2039/6031 ,  A61K2039/64 ,  C12N2720/12034 ,  C12N2740/16034 ,  C12N2760/16134

    Abstract: A fusion protein is provided which is based on a self-assembling gene- regulatory NSP10 protein and a protein or peptide capable of being fused to NSP10 without interfering with the assembly or aggregation of the resulting fusion protein. The disclosure also relates to any nanoparticle formed thereby whether complete or not, and methods for the use of the NSP10 fusion protein are also disclosed, including use as vaccines for any indication in humans or animals, therapeutic methods involving the use of the fusion proteins such as using the protein to targeted an antibody or receptor, such as for treating or diagnosing cancer, biosensors using the fusion protein, or the use of the fusion proteins in cell sorting or any imaging application.

    Abstract translation: 提供基于自组装基因调控NSP10蛋白和能够与NSP10融合而不干扰所得融合蛋白的装配或聚集的蛋白或肽的融合蛋白。 本公开还涉及由此形成的任何纳米颗粒是否完整，并且还公开了使用NSP10融合蛋白的方法，包括用作人或动物的任何适应症的疫苗，涉及使用融合蛋白的治疗方法，例如 如使用蛋白质靶向抗体或受体，例如用于治疗或诊断癌症，使用融合蛋白的生物传感器，或在细胞分选或任何成像应用中使用融合蛋白。

    NSP10 SELF-ASSEMBLING FUSION PROTEINS FOR VACCINES, THERAPEUTICS, DIAGNOSTICS AND OTHER NANOMATERIAL APPLICATIONS
    9.
    发明申请
    NSP10 SELF-ASSEMBLING FUSION PROTEINS FOR VACCINES, THERAPEUTICS, DIAGNOSTICS AND OTHER NANOMATERIAL APPLICATIONS 审中-公开
    用于疫苗，治疗学，诊断和其他纳米应用的NSP10自组装融合蛋白

    公开(公告)号：WO2017066484A2

    公开(公告)日：2017-04-20

    申请号：PCT/US2016/056904

    申请日：2016-10-13

    Applicant: CARTER, Daniel, C.

    Inventor： CARTER, Daniel, C.

    IPC: A61K39/12 ,  C07K19/00

    CPC classification number: A61K39/12 ,  A61K2039/6031 ,  A61K2039/64 ,  C12N2720/12034 ,  C12N2740/16034 ,  C12N2760/16134 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/392 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/414 ,  Y02A50/466

    Abstract: A fusion protein is provided which is based on a self-assembling gene- regulatory NSP10 protein and a protein or peptide capable of being fused to NSP10 without interfering with the assembly or aggregation of the resulting fusion protein. The disclosure also relates to any nanoparticle formed thereby whether complete or not, and methods for the use of the NSP10 fusion protein are also disclosed, including use as vaccines for any indication in humans or animals, therapeutic methods involving the use of the fusion proteins such as using the protein to targeted an antibody or receptor, such as for treating or diagnosing cancer, biosensors using the fusion protein, or the use of the fusion proteins in cell sorting or any imaging application.

    Abstract translation: 提供了基于自组装基因调节NSP10蛋白和能够与NSP10融合而不干扰所得融合蛋白的组装或聚集的蛋白或肽的融合蛋白。 本公开还涉及由此形成的任何纳米颗粒是否完整，并且还公开了使用NSP10融合蛋白的方法，包括用作人或动物的任何适应症的疫苗，涉及使用融合蛋白的治疗方法，例如 如使用蛋白质靶向抗体或受体，如用于治疗或诊断癌症，使用融合蛋白的生物传感器，或在细胞分选或任何成像应用中使用融合蛋白。

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